Anti-Ganglioside Antibody Negative Miller Fisher Syndrome with Atypical Features: A Case Report
Abstract
Miller Fisher Syndrome (MFS), a variant of Guillain Barre Syndrome (GBS), is an immune-mediated neuropathy presenting with the classical clinical triad of ophthalmoplegia, ataxia, and areflexia. Although the clinical triad is the cardinal diagnostic clue, it can also present with a variety of other atypical neurological symptoms and signs beyond the classical triad. IgG anti-GQ1b antibodies are a powerful serological marker for the diagnosis of MFS, however, they can be absent in 10-15% cases of MFS. Here, we are describing a case of a 55-year old lady with an anti-ganglioside negative case of MFS with ptosis and bulbar palsy, who improved with IVIg.
How to cite this article:
Iqbal A, Yadav A, Kummetha LC, Kumar N, Sharma G, Poonam P, Ahlawat RS. Anti-Ganglioside Antibody Negative Miller Fisher Syndrome with Atypical Features: A Case Report. Int J Preven Curat Comm Med. 2021;7(2):26-28.
DOI: https://doi.org/10.24321/2454.325X.202110
References
Mori M, Kuwabara S, Fukutake T, Yuki N, Hattori T. Clinical features and prognosis of Miller Fisher
syndrome. Neurol. 2001;56:1104-6. [PubMed] [Google Scholar]
Jung JH, Oh EH, Shin JH, Kim DS, Choi SY, Choi KD, Choi JH. Atypical clinical manifestations of Miller Fisher
syndrome. Neurol Sci. 2019;40:67-73. [PubMed] [Google Scholar]
Chiba A, Kusunoki S, Obata H, Machinami R, Kanazawa I. Serum anti-GQ1b IgG antibody is associated with
ophthalmoplegia in Miller Fisher syndrome and Guillain-Barré syndrome: clinical and immunohistochemical
studies. Neurol. 1993;43:1911-7. [PubMed] [Google Scholar]
Wakerley BR, Uncini A, Yuki N; GBS Classification Group. Erratum: Guillain-Barré and Miller Fisher
syndromes-new diagnostic classification. Nat Rev Neurol. 2014;10:537-44. [PubMed] [Google Scholar]
Chiba A, Kusunoki S, Shimizu T, Kanazawa I. Serum IgG antibody to ganglioside GQ1b is a possible marker of
Miller Fisher syndrome. Ann Neurol. 1992;31:677-9. [PubMed] [Google Scholar]
Koga M, Gilbert M, Takahashi M, Li J, Hirata K, KandaT, Yuki N. GQ1b-seronegative Fisher syndrome: clinical
features and new serological markers. J Neurol. 2012;259:1366-74. [PubMed] [Google Scholar]
Pietrini V, Pavesi G, Andreetta F. Miller Fisher syndrome with positivity of anti-GAD antibodies. Clin Neurol
Neurosurg. 2013;115:1479-81. [PubMed] [Google Scholar]
Ito H, Hatanaka Y, Fukami Y, Harada Y, Kobayashi R, Okada H, Uchibori A, Chiba A, Okuda S. Anti-ganglioside
complex antibody profiles in a recurrent complicated case of GQ1b-seronegative miller fisher syndrome
and Bickerstaff brainstem encephalitis: a case report. BMC Neurol. 2018;18:72. [PubMed] [Google Scholar]
Copyright (c) 2021 Author's

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.