Anti-Ganglioside Antibody Negative Miller Fisher Syndrome with Atypical Features: A Case Report

  • Asif Iqbal Resident, Deapartment of Medicine, Maulana Azad Medical College, New Delhi, India.
  • Abhishek Yadav Senior Resident, Deapartment of Medicine, Maulana Azad Medical College, New Delhi, India.
  • Lalit Chandra Kummetha Resident, Department of Medicine, Maulana Azad Medical College, New Delhi, India.
  • Naresh Kumar Professor of Medicine & Head, Pulmonary Medicine, Maulana Azad Medical College, New Delhi, India.
  • Gaurav Sharma Resident, Deapartment of Medicine, Maulana Azad Medical College, New Delhi, India.
  • Princey Poonam Resident, Deapartment of Medicine, Maulana Azad Medical College, New Delhi, India.
  • RS Ahlawat Director Professor, Maulana Azad Medical College, New Delhi, India.
Keywords: Guillain Barre Syndrome (GBS), Miller Fisher Syndrome (MFS), Anti-Ganglioside Negative, Atypical Features, Ptosis, Bulbar Palsy

Abstract

Miller Fisher Syndrome (MFS), a variant of Guillain Barre Syndrome (GBS), is an immune-mediated neuropathy presenting with the classical clinical triad of ophthalmoplegia, ataxia, and areflexia. Although the clinical triad is the cardinal diagnostic clue, it can also present with a variety of other atypical neurological symptoms and signs beyond the classical triad. IgG anti-GQ1b antibodies are a powerful serological marker for the diagnosis of MFS, however, they can be absent in 10-15% cases of MFS. Here, we are describing a case of a 55-year old lady with an anti-ganglioside negative case of MFS with ptosis and bulbar palsy, who improved with IVIg.

How to cite this article:
Iqbal A, Yadav A, Kummetha LC, Kumar N, Sharma G, Poonam P, Ahlawat RS. Anti-Ganglioside Antibody Negative Miller Fisher Syndrome with Atypical Features: A Case Report. Int J Preven Curat Comm Med. 2021;7(2):26-28.

DOI: https://doi.org/10.24321/2454.325X.202110

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Published
2021-06-30

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