Guillain Barre Syndrome in a Young Man with SARSCoV-2: A Rare Association
Abstract
Guillain Barre Syndrome (GBS) is usually a post-infectious autoimmune disease that manifests as acute ascending flaccid paralysis. The disease is usually uncommon. However, recently it was reported in a few COVID-19 cases before complete resolution of COVID symptoms. An association between olfactory-gustatory disturbances and sensory abnormalities is frequently observed in GBS with COVID-19. The electrophysiological studies usually reveal a demyelinating pattern. Respiratory involvement, as part of respiratory muscle paralysis or COVID-19 pneumonia, is associated with poor recovery in affected patients. Here, we present a case of a young man, pre-morbid healthy, who presented with GBS with mild COVID-19 infection. He successfully recovered after treatment with Intravenous immunoglobulin IVIg.
How to cite this article:
Dabas A, Kumar N. Guillain Barre Syndrome in a Young Man with SARSCoV-2: A Rare Association. J Adv Res Med 2021;8(1): 22-25.
DOI: https://doi.org/10.24321/2349.7181.202104
References
Lltaf S, Fatima M, Salman S, Salam J, Abbas S. Frequency of Neurological Presentations of Coronavirus Disease in Patients Presenting to a Tertiary Care Hospital During the 2019 Coronavirus Disease Pandemic. Cureus. 2020
Aug;12(8):-e9846. DOI 10.7759/cureus. 9846.
Filosto M, Piccinelli SC, Gazzina S, Foresti C, Frigeni B, Servalli MC, Sessa M, Cosentino G, Marchioni E,
Ravaglia S, Briani C, Castellani F, Zara G, Bianchi F, Del Carro U, Fazio R, Filippi M, Magni E, Natalini G,
Palmerini F, Perotti AM, Bellomo A, Osio M, Scopelliti G, Carpo M, Rasera A, Squintani G, Doneddu PE, Bertasi
V, Cotelli MS, Bertolasi L, Fabrizi GM, Ferrari S, Ranieri F, Caprioli F, Grappa E, Broglio L, De Maria G, Leggio U,
Poli L, Rasulo F, Latronico N, Nobile-Orazio E, Padovani A, Uncini A. Guillain-Barré syndrome and COVID-19:
an observational multicentre study from two Italian hotspot regions. J Neurol Neurosurg Psychiatry. 2020
Nov 6:jnnp-2020-324837. doi: 10.1136/jnnp-2020-324837. Pubmed. PMID: 33158914; Pubmed Central
PMCID: PMC7650204.
Fragiel M, Miró Ã’, Llorens P, Jiménez S, Piñera P, Burillo G, MartÃn A, MartÃn-Sánchez FJ, GarcÃa-Lamberechts
EJ, Jacob J, Alquézar-Arbé A, Juárez R, Jiménez B, Del Rio R, Mateo Roca M, GarcÃa AH, López Laguna N,
Lopez Diez MP, Pedraza GarcÃa J, Fernández de Simón Almela A, Lopez Diaz JJ, Eiroa Hernández P, Ruiz de
Lobera N, Porta-Etessam J, Fernández Pérez C, Calvo E, González Del Castillo J; SIESTA (Spanish Investigators
in Emergency Situations Team) network. Incidence, clinical, risk factors and outcomes of Guillain-Barré in
Covid-19. Ann Neurol. 2021 Mar;89(3):598-603. doi: 10.1002/ana.25987. Pubmed. PMID: 33295021.
Abu-Rumeileh S, Abdelhak A, Foschi M, Tumani H, Otto M. Guillain-Barré syndrome spectrum associated
with COVID-19: an up-to-date systematic review of 73 cases. J Neurol. 2021 Apr;268(4):1133-70. doi: 10.1007/
s00415-020-10124-x. Pubmed PMID: 32840686; Pubmed Central PMCID: PMC7445716.
Kajumba MM, Kolls BJ, Koltai DC, Kaddumukasa M, Kaddumukasa M, Laskowitz DT. COVID-19-Associated
Guillain-Barre Syndrome: Atypical Para-infectious Profile, Symptom Overlap, and Increased Risk of
Severe Neurological Complications. SN Compr Clin Med. 2020 Nov 21:1-13. doi: 10.1007/s42399-020-
-w. Pubmed PMID: 33251483; Pubmed Central PMCID: PMC7680081.
De Sanctis P, Doneddu PE, Viganò L, Selmi C, Nobile- Orazio E. Guillain-Barré syndrome associated with
SARS-CoV-2 infection. A systematic review. Eur J Neurol. 2020 Nov;27(11):2361-70. doi: 10.1111/ene.14462.
Pubmed, PMID: 32757404; Pubmed Central PMCID: PMC7436512.
Keddie S, Pakpoor J, Mousele C, Pipis M, Machado PM, Foster M, Record CJ, Keh RYS, Fehmi J, Paterson RW,
Bharambe V, Clayton LM, Allen C, Price O, Wall J, Kiss-Csenki A, Rathnasabapathi DP, Geraldes R, Yermakova
T, King-Robson J, Zosmer M, Rajakulendran S, Sumaria S, Farmer SF, Nortley R, Marshall CR, Newman EJ,
Nirmalananthan N, Kumar G, Pinto AA, Holt J, Lavin TM, Brennan KM, Zandi MS, Jayaseelan DL, Pritchard
J, Hadden RDM, Manji H, Willison HJ, Rinaldi S, Carr AS, Lunn MP. Epidemiological and cohort study finds
no association between COVID-19 and Guillain-Barré syndrome. Brain. 2021 Mar 3;144(2):682-93. doi:
1093/brain/awaa433. Pubmed PMID: 33313649.
Van den Berg B, Walgaard C, Drenthen J, Fokke C, Jacobs BC, van Doorn PA. Gullian Barre syndrome:
Pathogenesis, diagnosis, treatment and prognosis. Nat Rev Neurol. 2014; Aug;10(8):469-82.9. Sriwastava S, Kataria S, Tandon M, Patel J, Patel R, Jowkar A, Daimee M, Bernitsas E, Jaiswal P, Lisak RP. Guillain Barré Syndrome and its variants as a manifestation of COVID-19: A systematic review of case reports and case series. J Neurol Sci. 2021 Jan 15;420:117263. doi10.1016/jns.2020.117263. Pubmed PMID: 33321326; Pubmed Central PMCID:
PMC7725056.
Centres for Disease Control and Prevention (Internet). Gullian Barre syndrome and Vaccines. Available from:
https://www.cdc.gov/vaccinesafety/concerns/guillainbarre-syndrome.html#:~:text=When%20there%20
has%20been%20an,the%20flu%20than%20after%20vaccination.
