To Study the Prevalence of Osteopenia and Osteoporosis in Patients with COPD and to Correlate Severity of COPD with Prevalence of Osteopenia and Osteoporosis
Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory airway disease characterized by both pulmonary and systemic inflammatory response and associated extra-pulmonary complications. Female gender, age and smoking are common pathogenic risk factors for both COPD and osteoporosis. Many other factors like low daily physical activity, chronic malnutrition, hypogonadism, vitamin D deficiency and chronic steroid therapy are risk factors for osteoporosis.
Objectives: The study was done to evaluate the prevalence of osteopenia and osteoporosis in patients of COPD and to correlate the severity of COPD with osteopenia/ osteoporosis.
Material & Method: The study was conducted at a tertiary care hospital in Delhi after ethical clearance from institutional review board. Total of 76 patients of both genders were taken. COPD diagnosis and staging was done as per Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. Bone mineral density (BMD) was evaluated by DEXA scan in all patients. All data was entered in preformed data sheets. Statistical analysis for association of COPD with osteoporosis was done by chi-square test.
Result: Mostly patients were having either osteopenia or osteoporosis, only 6% patients were having normal BMD. COPD stage III-IV were having significant bone mass loss. Those having long smoking history were more osteoporotic as compared to others.
Conclusion: There is a very high prevalence of osteopenia and osteoporosis in COPD patients especially those with prolonged smoking history, GOLD stage III-IV. 35.5% of COPD patients had osteopenia and 57.9 % had osteoporosis.
How to cite this article:
Khura J, Priyanka, Shakarwal S, Singh P. To Study the Prevalence of Osteopenia and Osteoporosis in Patients with COPD and to Correlate Severity of COPD with Prevalence of Osteopenia and Osteoporosis. J Adv Res Med. 2021; 8(2): 1-4.
Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS. Global strategy for the diagnosis, management, and
prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive
Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med. 2001;163(5):1256-76. [PubMed] [Google
Jindal SK. COPD: The unrecognized epidemic in India.J Asso Physicians India. 2012;60:14-16. [PubMed]
Barnes PJ and Celli BR. Systemic manifestations, and comorbidities of COPD. Eur Respair J .2009; 33: 1165-
[PubMed] [Google Scholar]
Daisuke Inoue, Reiko Watanabe, Ryo Okazaki. COPD and osteoporosis: links, risks, and treatment challenges.
Int J Chron Obstruct Pulmon Dis. 2016;11:637-648. [PubMed] [Google Scholar]
Leech JA, Dulberg C, Kellie S, Pattee L, Gay J. Relationship of lung function to severity of osteoporosis in women. Am Rev Respir Dis. 1990;141:68-71. [PubMed] [Google Scholar]
Walsh LJ, Wong CA, Oborne J, Cooper S, Lewis SA, Pringle M, Hubbard R, Taatersfield AE. Adverse effects
of oral corticosteroids in relation to dose in patients with lung disease. Thorax. 2001;56:279-284. [PubMed]
Jorgensen NR, Schwarz P. Osteoporosis in chronic obstructive pulmonary disease patients. Curr Opin
Pulm Med 2008; 14:122-127. [Google Scholar]
The TORCH Study Group. The TORCH (Towards a Revolution in COPD Health) survival study protocol. Eur
Respir J. 2004; 24:206-10. [PubMed] [Google Scholar]
Vrieze A, de Greef MH, Wijkstra PJ, Wempe JB. Low bone mineral density in COPD patients related to worse
lung function, low weight and decreased fat-free mass. Osteoporosis Int 2007; 18: 1197–1202. [PubMed]
Jorgensen NR, Schwarz P, Holme I, Henriksen BM, Petersen LJ, Backer V. The prevalence of osteoporosis in
patients with chronic obstructive pulmonary disease: a cross sectional study. Respir Med 2007; 101: 177–185.
[PubMed] [Google Scholar]
Biskobing DM. COPD and osteoporosis. Chest. 2002; 121:609–620. [PubMed] [Google Scholar]
Naylor K, Eastell R. Bone turnover markers: use in osteoporosis. Nat Rev Rheumatol. 2012;8(7):379–
[PubMed] [Google Scholar]
Daga MK, Bharali D, Gupta B, Mawari G, Hira HS. Assessment of osteoporosis and osteopenia and
its co-relation with disease severity in patients of chronic obstructive pulmonary disease with respect
to associated risk factors: A case control study in India. J Pulm Respir Med. 2018;8:456-61. [Google Scholar]
Slemenda CW, Hui SL, Longcope C, et al. Cigarette smoking, obesity, and bone mass. J Bone Miner Res
Ciappi G, Pistelli R. [PubMed] [Google Scholar]16. Daga MK, Kumar N, Raghav RV, Marwari G, Chand S, Aarthi J, Jha MK, Hussain M. Osteoporosis in chronic obstructive pulmonary disease: More than just a comorbidity. J
Adv Res Med. 2020; 3:7-12. [Google Scholar]
Gan WQ, Man SFP, Senthilselvan A, Sin DD . Association between chronic obstructive pulmonary disease and
systemic inflammation: a systematic review and a meta-analysis. Thorax. 2004;59:574e80. [PubMed]
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