Terlipressin Induced Skin Ischemia: A Case Report
Abstract
Terlipressin is a synthetic vasopressin analogue used in the treatment of cirrhotic patients with variceal bleeding and hepatorenal syndrome. Side effects associated with terlipressin are usually mild but some rare serious complications can also be seen. Terlipressin induced skin ischemia is one such serious complication. We report a case of 57-year-old lady, a case of chronic alcoholic liver disease presented with variceal bleeding. Patient was given bolus injection terlipressin every 4 hour and patient developed skin ischemia within 48 hours of terlipressin administration. Skin ischemic changes showed marked improvement after stoppage of terlipressin. Treating clinicians should be more vigilant about this rare adverse effect of terlipressin. Early recognition and treatment of the ischemic skin complication gives a better outcome.
How to cite this article:
Kumar N, Bohania N, Kumar S. Terlipressin Induced Skin Ischemia: A Case Report. J Adv Res Med 2019; 6(4): 10-12.
DOI: https://doi.org/10.24321/2349.7181.201918
References
Krag A, Borup T, Moller S, Bendtsen F. Efficacy and safety of terlipressin in cirrhotic patients with variceal
bleeding or hepatorenal syndrome. Adv Ther 2008; 25: 1105-1140.
Sahu S, Panda K, Patnaik S, Rath J. Terlipressin induced peripheral ischaemic gangrene and skin necrosis. Trop
Gastroenterol 2010; 2013: 229-230.
Yefet E, Gershovich M, Farber E, Soboh S. Extensive epidermal necrosis due to terlipressin. Isr Med Assoc J
; 2013: 180-181.
Vaccaro F, Giorgi A, Riggio O et al. Is spontaneous bacterial peritonitis an inducer of vasopressin analogue
side-effects? A case report. Dig Liver Dis 2003; 35: 503-506.
Halimi C, Bonnard P, Bernard B et al. Effect of terlipressin (Glypressin) on hepatorenal syndrome in cirrhotic
patients: results of a multicentre pilot study. Eur J Gastroenterol Hepatol 2002; 14: 153-158.
Oh JE, Ha JS, Cho DH et al. A case of ischemic skin necrosis after glypressin therapy in liver cirrhosis. Korean
J Gastroenterol 2008; 51(6): 381-384.
Sarma P, Muktesh G, Singh RS et al. Terlipressin-Induced ischemic complications: A systematic review
of published case reports. J Pharmacol Pharmacother 2018; 9: 76-85.
