Symmetrical Peripheral Gangrene: A Rare Complication of Malaria
Abstract
Symmetrical Peripheral Gangrene (SPG) is one of the very rare and devastating complication of malaria. We report a 45-year-old gentleman who presented with fever and blackish discoloration of digits. Examination revealed mild splenomegaly, cold peripheries with dry gangrene involving bilateral fingers and toes. Investigations revealed thrombocytopenia and transaminitis. Rapid malaria test was positive for both Plasmodium falciparum and Plasmodium vivax. Patient was treated with antimalarials. Clinicians managing malaria should be more vigilant for this rare devastating complication.
How to cite this article:
Kumar N, Bohania N, Anuradha S. Symmetrical Peripheral Gangrene: A Rare Complication of Malaria. J Adv Res Med 2019; 6(3): 16-18.
DOI: https://doi.org/10.24321/2349.7181.201915
References
Sharma BD, Kabra SR, Gupta B. Symmetrical peripheral gangrene. Trop Doct 2004; 34(1): 2-4.
Available from: https://journals.sagepub.com/doi/abs/10.1177/004947550403400102 [PubMed/ Google
Scholar].
Nicholas JW, Joel GB. Malaria. In: Longo DL, Fauci AS, Kasper DL, et al, editors. Harrison’s Principles of
Internal Medicine. 18th ed. McGraw Hill, New York. 2012; 1688-703.
Clemens R, Pramoolsinsap C, Lorenz R, Pukrittayakamee S, Bock HL, White NJ. Activation of the coagulation
cascade in severe falciparum malaria through the intrinsic pathway. Br J Haematol 1994; 87(1): 100-105.
Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2141.1994.tb04877.x?sid=nlm%3A
pubmed [PubMed/ Google Scholar].
Philips RE, Looaresuwan S, Warrell DA, Lee SH, Karbwang J, Warrell MJ et al. The importance of
anaemia in cerebral and uncomplicated falciparum malaria: role of complications, dyserythropoesis, and
iron sequestration. Quart J Med 1986; 58(227): 305-323. Available from: https://academic.oup.com/qjmed/
article-abstract/58/3-4/305/1560540?redirectedFrom=PDF [PubMed/ Google Scholar].
Ghosh SK, Bandyopadhyay D. Symmetrical peripheral gangrene. Indian J Dermatol Venerol Leprol 2011; 77(2):
-248. Available from: http://www.ijdvl.com/article.asp?issn=0378-6323;year=2011;volume=77;issue=2;s
page=244;epage=248;aulast=Ghosh [Google Scholar].
Parmar MS. Symmetrical peripheral gangrene: a rare but dreadful complication of sepsis. CMAJ 2002; 167(9):
-1038. Available from: https://www.cmaj.ca/content/167/9/1037.long [PubMed/ Google Scholar].
Ghosh S, Bandyopadhyay D, Ghosh A. Symmetrical peripheral gangrene: a prospective study of 14
consecutive cases in a tertiary-care hospital in eastern India. Journal of the European Academy of Dermatology
and Venereology 2010; 24: 214-218. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/
j.1468-3083.2009.03329.x [PubMed/ Google Scholar].
Kumbhalkar S, Aher S, Wanjari S. Symmetrical peripheral gangrene: A rare complication of Plasmodium
falciparum malaria. Ann Trop Med Public Health 2017; 10(1): 238-240. Available from: http://www.atmph.
org/article.asp?issn=1755-6783;year=2017;volume=10;issue=1;spage=238;epage=240;aulast=Kumbhalkar.
Prabhat K, Ghazal T, Gupta H, Dixit J. Symmetrical peripheral gangrene in severe Plasmodium Vivax
malaria. Indian J Crit Care Med 2017; 21: 245-246. Available from: https://www.ijccm.org/doi/
pdf/10.4103/ijccm.IJCCM_424_16 [PubMed/ Google Scholar].