Current Pattern and Clinico-Bacteriological Profile of Healthcare Associated Infections in an ICU Setting: A Study from a Tertiary Care Centre in Delhi

  • Naresh Kumar Department of Medicine, Maulana Azad Medical College, New Delhi, India.
  • Saman Wasi Department of Medicine, Maulana Azad Medical College, New Delhi, India.
  • Mradul Kumar Daga Internal Medicine and Infectious Disease, Institute of Liver and Biliary Sciences, New Delhi, India.
  • Govind Mawari Centre for Occupational and Environment Health (COEH), Maulana Azad Medical College, New Delhi, India.
  • Udbhav Sharma Department of Medicine, Maulana Azad Medical College, New Delhi, India.
  • Maryam Hussain Department of Medicine, Maulana Azad Medical College, New Delhi, India.
  • CP Baveja Department of Microbiology, Maulana Azad Medical College, New Delhi, India.
Keywords: Healthcare Associated Infections (HAI), Ventilator Associated Pneumonia (VAP), Catheter Associated Urinary Tract Infection (CAUTI), Central Line Associated Bloodstream Infection (CLABSI)


Background: Global prevalence of healthcare associated infections (HAI) ranges anywhere between 7% and 12% as per WHO estimates. This study was undertaken to understand the pattern and types of HAI at a selected healthcare facility and determine the common causative agents and their antibiotic susceptibility profile.

Methods: One hundred consecutive patients diagnosed with HAI were enrolled and monitored; the causative organisms isolated on culture were recorded and their sensitivity profile was generated.

Results: There were a total of 110 hospital acquired infections with 10 patients having two infections each. 69 patients had ventilator associated pneumonia (VAP), 21 catheter associated urinary tract infection (CAUTI) patients, 20 central line associated bloodstream infection (CLABSI), and 10 patients had both VAP and CAUTI. All of the HAIs were device associated. 76 pathogens were isolated on culture. No organism was isolated in 40 HAI. Majority (94.7%) of the organisms were gram-negative and all were multidrug resistant. Seventy-seven of the enrolled patients expired while 23 were discharged from the hospital

Conclusions: This study demonstrated that HAIs occur in patients of all age groups; younger patients are not spared. Majority of the HAIs were caused by multidrug resistant gram-negative bacteria and were associated with high patient mortality. Acinetobacter species was the most common organism associated with HAI.

How to cite this article:
Wasi S, Daga MK, Mawari G, Kumar N, Sharma U, Hussain M, Baveja CP. Current Pattern and Clinico-Bacteriological Profile of Healthcare Associated Infections in an ICU Setting: A Study from a Tertiary Care Centre in Delhi. J Adv Res Med. 2022;9(1):1-10.



G. Ducel J, Fabry, L. Nicolle. Prevention of hospitalacquired infections : a practical guide. Geneva, Switizerland: WHO; 2002.

V Ramasubramanian VI, Sandeep Sewlikar, Anish Desai. Epidemiology of healthcare acquired infection – An Indian perspective on surgical site infection and catheter related blood stream infection. Indian journal of basic and applied medical research. 2014;3(4):46-63. [Google Scholar]

Vincent JL, Rello J, Marshall J, Silva E, Anzueto A, Martin CD, Moreno R, Lipman J, Gomersall C, Sakr Y, Reinhart K. International study of the prevalence and outcomes of infection in intensive care units. Jama. 2009 Dec 2;302(21):2323-9. [PubMed] [Google Scholar]

WHO [Internet]. Report on the burden of endemic health care-associated infection worldwide. 2011 [cited 2021 Dec 24].

Richards MJ, Edwards JR, Culver DH, Gaynes RP. Nosocomial infections in combined medical-surgical intensive care units in the United States. Infection control and hospital epidemiology. 2000;21(8):510-5. [PubMed] [Google Scholar]

Habibi S, Wig N, Agarwal S, Sharma SK, Lodha R, Pandey RM, Kapil A. Epidemiology of nosocomial infections in medicine intensive care unit at a tertiary care hospital in northern India. Tropical doctor. 2008 Oct;38(4):233-5. [PubMed] [Google Scholar]

Mehta Y, Jaggi N, Rosenthal VD, Kavathekar M, Sakle A, Munshi N, Chakravarthy M, Todi SK, Saini N, Rodrigues C, Varma K. Device-Associated Infection Rates in 20 Cities of India, Data Summary for 2004-2013: Findings of the International Nosocomial Infection Control Consortium. Infection control and hospital epidemiology. 2016;37(2):172-81. [PubMed] [Google Scholar]

Ling ML, Apisarnthanarak A, Madriaga G. The Burden of Healthcare-Associated Infections in Southeast Asia: A Systematic Literature Review and Meta-analysis. Clin Infect Dis. 2015;60(11):1690–1699. [PubMed] [Google Scholar]

Magill SS, Edwards JR, Bamberg W, Beldavs ZG, Dumyati G, Kainer MA, Lynfield R, Maloney M, McAllister-Hollod L, Nadle J, Ray SM. Multistate point-prevalence survey of health care-associated infections. New Eng J Med. 2014;370(13):1198-208. [PubMed] [Google Scholar]

Dasgupta S, Das S, Chawan NS, Hazra A. Nosocomial infections in the intensive care unit: Incidence, risk factors, outcome and associated pathogens in a public tertiary teaching hospital of Eastern India. Indian J Crit Care Med. 2015;19(1):14-20. [PubMed] [Google Scholar]

Ghanshani R, Gupta R, Gupta BS, Kalra S, Khedar RS, Sood S. Epidemiological study of prevalence, determinants, and outcomes of infections in medical ICU at a tertiary care hospital in India. Lung India: Official Organ of Indian Chest Society. 2015;32(5):441-8. [PubMed] [Google Scholar]

Cook DJ, Walter SD, Cook RJ, Griffith LE, Guyatt GH, Leasa D, Jaeschke RZ, Brun-Buisson C. Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann Int Med. 1998 Sep 15;129(6):433-40. [PubMed] [Google Scholar]

Rello J, Ollendorf DA, Oster G, Vera-Llonch M, Bellm L, Redman R, Kollef MH. Group VAPOSA. Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest. 2002;122:2115-2121. [PubMed] [Google Scholar]

Li F, Song M, Xu L, Deng B, Zhu S, Li X. Risk factors for catheter-associated urinary tract infection among hospitalized patients: A systematic review and meta-analysis of observational studies. J Adv Nurs. 2019;75(3):517-27. [PubMed] [Google Scholar]

Weiner LM, Webb AK, Limbago B, Dudeck MA, Patel J, Kallen AJ, Edwards JR, Sievert DM. Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2011-2014. Infect Control Hosp Epidemiol. 2016;37(11):1288-301. [PubMed] [Google Scholar]

Gaynes R, Edwards JR. Overview of nosocomial infections caused by gram-negative bacilli. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2005;41(6):848-54. [PubMed] [Google Scholar]

Liu S, Wang M, Zheng L, Guan W. Antimicrobial Resistance Profiles of Nosocomial Pathogens in Regional China: A Brief Report from Two Tertiary Hospitals in China. Med Sci Monit. 2018;24:8602-7. [PubMed] [Google Scholar]

Datta P, Rani H, Chauhan R, Gombar S, Chander J. Health-care-associated infections: Risk factors and epidemiology from an intensive care unit in Northern India. Indian Journal of Anaesthesia. 2014;58(1):30-5. [PubMed] [Google Scholar]


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