The Role of IL-6 in Inflammatory Reaction during Coronavirus-19 Infection: A Review

Aesha S Ali; Sadeq K Hachim; Zainab M Saleh

Aesha S Ali Assistant Lecturer, Department of Microbiology, College of Medicine, Kirkuk University, Kirkuk, Iraq.
Sadeq K Hachim Lecturer, PhD Medical Microbiology, Institute of Medical Technology, Baghdad, Middle Technical University, Iraq.
Zainab M Saleh Assistant Lecturer, Department of Pharmacy, Ashur University College, Iraq.

Keywords: COVID-19, IL-6, Inflammation, Cytokine

Abstract

Interleukin 6 (IL-6) is an interleukin that works as a proinflammatory cytokine and as an anti-inflammatory myokine. The production of IL-6 in humans is under genetic control. IL-6 is a pleiotropic cytokine created in response to tissue injury and infections. IL-6 is one of the basic cytokines after stimulated macrophages. Hence, control of systemic IL-6 levels in SARS-CoV-2 infected patients may be a consideration for COVID-19 disease. This review will focus on the role of IL-6 in diagnosis and follow up of infection in addition to being the target for treatment.

How to cite this article:
Ali AS, Hachim SK, Saleh ZM. The Role of IL-6 in Inflammatory Reaction during Coronavirus-19 Infection: A Review. Special Issue - COVID-19 & Other Communicable Disease. 2022;210-214.

DOI: https://doi.org/10.24321/0019.5138.202233

References

Mauer J, Denson JL, Bruning JC. Versatile functions for IL-6 in metabolism and cancer. Trends Immunol. 2015 Feb;36:92-101. [PubMed] [Google Scholar]

Scheller J, Chalaris A, Schmidt-Arras D, Rose-John S. The pro- and anti-inflammatory properties of the cytokine interleukin-6. Biochim Biophys Acta. 2011 May;1813:878-88. [PubMed] [Google Scholar]

Chomarat P, Banchereau J, Davoust J, Palucka AK. IL-6 switches the differentiation of monocytes from dendritic cells to macrophages. Nat Immunol. 2000 Dec;1:510-4. [PubMed] [Google Scholar]

Yang R, Masters AR, Fortner KA, Champagne DP, Yanguas-CasÃ¡s N, Silberger DJ, Weaver CT, Haynes L, Rincon M. IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells. J Exp Med. 2016 Oct;213:2281-91. [PubMed] [Google Scholar]

Park SJ, Nakagawa T, Kitamura H, Atsumi T, Kamon H, Sawa S, Kamimura D, Ueda N, Iwakura Y, Ishihara K, Murakami M, Hirano T. IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation. J Immuno. 2004 Sep;173:3844-54. [PubMed] [Google Scholar]

Green AM, Difazio R, Flynn JL. IFN-gamma from CD4 T cells is essential for host survival and enhances CD8

T cell function during Mycobacterium tuberculosis infection. J Immunol. 2013 Jan;190:270-7. [PubMed]

[Google Scholar]

Guglani L, Khader SA. Th17 cytokines in mucosal immunity and inflammation. Curr Opin HIV AIDS. 2010 Mar;5(2):120-7. [PubMed] [Google Scholar]

Cox MA, Kahan SM, Zajac AJ. Anti-viral CD8 T cells and the cytokines that they love. Virology. 2013 Jan;435:157-69. [PubMed] [Google Scholar]

Evans SS, Repasky EA, Fisher DT. Fever and the thermal regulation of immunity: the immune system feels the heat. Nat Rev Immuno. 2015 Jun;15:335-49. [PubMed] [Google Scholar]

Russell CD, Millar JE, Baillie JK. Clinical evidence does not support corticosteroid treatment for 2019-nCoV

lung injury. Lancet. 2020 Feb;395:473-5. [PubMed] [Google Scholar]

Dong L, Hu S, Gao J. Discovering drugs to treat coronavirus disease 2019 (COVID-19). Drug Discov Ther. 2020;14:58-60. [PubMed] [Google Scholar]

Wang WK, Chen SY, Liu IJ, Kao CL, Chen HL, Chiang BL, Wang JT, Sheng WH, Hsueh PR, Yang CF, Yang PC, Chang

SC; Severe Acute Respiratory Syndrome Research Group of the National Taiwan University College of Medicine/ NTU Hospital. Temporal relationship of viral load, ribavirin, interleukin (IL)-6, IL-8, and clinical progression