Novel Approach in the Management of Cutaneous Viral Wart through a Poly Herbo-mineral Topical Medication

  • Ahamed Basha Abdul Bari Professor of Physiology, Chettinad Hospital and Research Institute, Chettinad Academy of Research Institute, Rajiv Gandhi Salai, Kelambakkam, Chengalpattu District, Tamil Nadu, India.
  • Selvin Innocent Dhas Director, Selvin Clinic (Multispecialty Siddha Heal Centre), Thuckalay, Kanyakumari, India.
Keywords: Siddha Medicine, Herbo-mineral, Verruca Vulgaris, Verruca Filiformis


Background: Clinicians used to treat cutaneous viral warts - Verruca vulgaris and Verruca filiformis by means of either topical application of medicines or through minimal intervention. However, there is no single standard treatment protocol that can be applied to all patients suffering from the above conditions. Hence, there is a need for a single novel drug for the management of viral warts.
Aim: A novel poly herbo-mineral topical medicine (PHMTM) was prepared based on the Siddha system of medicine’s literature and this study was done to evaluate its efficacy against Verruca vulgaris and Verruca filiformis on various body sites.
Method: Patients diagnosed with Verruca vulgaris and Verruca filiformis were divided into two groups. PHMTM was applied on the lesion area as a topical application. Depending on the site and severity of the viral wart, the duration and days of application were decided and the drug was applied daily till automatic fall or till suitability for mild pluck and its response was noted.
Result: Verruca vulgaris that was present on the face, abdomen, and lower limb was cleared 100% when compared to the upper limb, for which the success rate was only 83%. Further, patients who exhibited complete clearance for Verruca filiformis were 100% in all the sites studied. The efficacy of the drug for Verruca filiformis is better when compared to the response for Verruca vulgaris.
Conclusion: PHMTM is found to offer a better success rate in the clearance of warts studied.

How to cite this article:
Bari ABA, Dhas SI. Novel Approach in the Management of Cutaneous Viral Wart through a Poly Herbo-mineral Topical Medication. J Commun Dis. 2022;54(1):25-30.



Al Aboud AM, Nigam PK. Wart. Treasure Island (FL): StatPearls Publishing; 2021 Jan.

Thas JJ. Siddha medicine-background and principles and the application for skin diseases. Clin Dermatol. 2008 Jan-Feb;26(1):62-78. [PubMed] [Google Scholar]

Ozbun MA, Bondu V, Patterson NA, Sterk RT, Waxman AG, Bennett EC, McKee R, Sharma A, Yarwood J, Rogers M, Eichenbaum G. Infectious titres of human papilloma viruses (HPVs) in patient lesions, methodological considerations in evaluating HPV infectivity and implications for the efficacy of high-level disinfectants. E Bio Medicine. 2021 Jan;63:103165. [PubMed] [Google Scholar]

Egawa N, Doorbar J. The low-risk papilloma viruses. Virus Res. 2017 Mar;231:119-27. [PubMed] [Google Scholar]

Houlihan CF, Baisley K, Bravo IG, Pavón MA, Changalucha J, Kapiga S, De Sanjosé S, Ross DA, Hayes RJ, Watson-

Jones D. Human papilloma virus DNA detected in finger tip, oral and bathroom samples from unvaccinated adolescent girls in Tanzania. Sex Transm Infect. 2019 Aug;95(5):374-9. [PubMed] [Google Scholar]

Yuan Y, Cai X, Shen F, Ma F. HPV post-infection microenvironment and cervical cancer. Cancer Lett. 2021 Jan;497:243-54. [PubMed] [Google Scholar]

Magalhães GM, Vieira ÉC, Garcia LC, De Carvalho-Leite M de LR, Guedes ACM, Araújo MG. Update on human papilloma virus - part I: epidemiology, pathogenesis, and clinical spectrum. An Bras Dermatol. 2021 Jan-Feb;96(1):1-16. [PubMed] [Google Scholar]

Loo SK-F, Tang WY-M. Warts (non-genital). BMJ Clin Evid. 2009 Sep;2009:1710. [PubMed] [Google Scholar]

Osmani V, Klug SJ. [HPV vaccination and the prevention of genital warts and precancerous lesions-current evidence and evaluation]. Bundesgesundhe its blatt Gesundhe its for schung Gesundhe its schutz. 2021 May;64(5):590-9. German. [PubMed] [Google Scholar]

Bencini PL, Guida S, Cazzaniga S, Pellacani G, Galimberti MG, Bencini M, Naldi L. Risk factors for recurrence after successful treatment of warts: the role of smoking habits. J Eur Acad Dermatol Venereol. 2017 Apr;31(4):712-6. [PubMed] [Google Scholar]

Jiang SB, Lu YS, Zhang YH, Wu Y, Wang HX, Gao XH, Chen HD. A retrospective study of a Chinese traditional medicine YIKEER in the treatment of Verruca patients in Liaoning district. Evid Based Complement Alternat Med. 2019 Dec;2019:9896148. [PubMed] [Google Scholar]

Subbarayappa BV. Siddha medicine: an overview. Lancet. 1997 Dec;350(9094):1841-4. [PubMed] [Google Scholar]

The Siddha Pharmacopoeia of India: Part 1. Government of India, Ministry of Health and Family Welfare, Department of Ayurveda, Yoga & Naturopathy, Unani, Siddha, and Homoeopathy; 2008.

Arunadevi R, Susila R, Murugammal S, Divya S. Preparation and standardization of Mathan Tailam: a classical Siddha formulation for diabetic ulcerative wound healing. J Ayurveda Integr Med. 2020 Jan-Mar;11(1):10-5. [PubMed] [Google Scholar]

Kwok CS, Gibbs S, Bennett C, Holland R, Abbott R. Topical treatments for cutaneous warts. Cochrane Database Syst Rev. 2012 Sep;2012(9):CD001781. [PubMed] [Google Scholar]

Madan RK, Levitt J. A review of toxicity from topical salicylic acid preparations. J Am Acad Dermatol. 2014 Apr;70(4):788-92. [PubMed] [Google Scholar]

Clebak KT, Mendez-Miller M, Croad J. Cutaneous cryosurgery for common skin conditions. Am Fam Physician. 2020 Apr;101(7):399-406. [PubMed] [Google Scholar]

Borkow G. Using copper to improve the well-being of the skin. Curr Chem Biol. 2014 Aug;8(2):89-102. [PubMed] [Google Scholar]

Mishra A, Das BC. Curcumin as an anti-human papillomavirus and anti-cancer compound. Future Oncol. 2015 Sep;11(18):2487-90. [PubMed] [Google Scholar]

Kaur A, Batish DR, Kaur S, Chauhan BS. An overview of the characteristics and potential of Calotropis procera from botanical, ecological, and economic perspectives. Front Plant Sci. 2021 Jun;12:690806. [PubMed] [Google Scholar]

Jaiprakash B, Chandramohan, Reddy DN. Burn wound healing activity of Euphorbia hirta. Anc Sci Life. 2006 Jan;25(3-4):16-8. [PubMed] [Google Scholar]

Tuhin RH, Begum MM, Rahman MS, Karim R, Begum T, Ahmed SU, Mostofa R, Hossain A, Abdel-Daim M, Begum R. Wound healing effect of Euphorbia hirta linn. (Euphorbiaceae) in alloxan induced diabetic rats. BMC Complement Altern Med. 2017 Aug;17(1):423. [PubMed] [Google Scholar]

Srinivas G, Geeta HP, Vasanthkumar GD, Nidoni U. Therapeutic properties of Euphorbia hirta Linn. medicinal plants. Int J Phytomed Relat Ind. 2015;7(4):253-7.