Evaluation of a Few Biomarkers among COVID-19 Patients

Rusul Heider Mohsin; Deemah Saeb Abdul Hussein; Ahmed S Abed

Rusul Heider Mohsin Department of Anesthesia, Hilla University Collage, Babylon, Iraq.
Deemah Saeb Abdul Hussein Department of Anesthesia, Hilla University Collage, Babylon, Iraq.
Ahmed S Abed Department of Medical Physics, Hilla University Collage, Babylon, Iraq.

Keywords: COVID-19, Lactate Dehydrogenase (LDH), IL-6, D-dimer, C-reactive Protein, Ferritin

Abstract

Introduction: In the present study, the mean differences of Lactate Dehydrogenase (LDH), D-dimer, C-reactive protein, interleukin-6 and ferritin levels concentrations between study groups (patients with severe COVID-19 symptoms and patients with mild symptoms) compared tothe control group. The results showed that there were significant increased concentrations of biomarkers levels in group A as compared with group B and control.

Objective: This present study aims to evaluate the COVID-19 biomarkers(Lactate Dehydrogenase (LDH), D-dimer, C-reactive protein, IL-6 and ferritin concentrations) among COVID-19 patients.

Methodology: A total of 75 blood samples were collected from male patients with age groups ranging between 30 and 75 years who were suffering from coronavirus. Three groups were included in this study; each group includes 25 patients. Group A patients suffering from coronavirus with severe symptoms, group B patients suffering from coronavirus with mild symptoms and group C with healthy patients as control. All parameters were measured according to standard procedures. Data were analysed in SPSS version 20 by using mean Â± SD.Significant association was established by chi-square test taking p-value<0.05.

Results: Increased LDH values were linked to an increase in COVID-19 toxicity. On the basis of D-dimer, the probability of mortality can be determined. C-responsive protein and ferritin serum exercises were significantly increased in COVID-19 patients compared to those with mild side effects of COVID-19. IL-6 is a key immunomodulatory cytokine in both normal and infected tissues.

Conclusion: LDH, D-dimer, C-reactive protein and serum ferritin are good predictors of COVID-19 severity and may be used for the assessment of clinical outcome.

How to cite this article:
Mohsin RH, Hussein DSA, Abed AS. Evaluation of a Few Biomarkers among COVID-19 Patients. Special Issue - COVID-19 & Other Communicable Disease. 2022;82-90.

DOI: https://doi.org/10.24321/0019.5138.202213

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