The Correlation between Caspase-1 Polymorphisms and COVID-19 Severity Score of Recovered Iraqi Patients

Siham Abbas Jabber; Ali Hussein Alwan

Siham Abbas Jabber Fatima AL- Zahraa Hospital, Ministry of Health, Iraq.
Ali Hussein Alwan Department of Biology, College of Science, University of Mustansiriyah, Iraq.

Keywords: Coronavirus, Acute Respiratory Syndrome

Abstract

Severe Acute Respiratory Syndrome Corona Virus-2, responsible for the Coronavirus disease 2019 (COVID-19) pandemic, is a single-stranded RNA-enveloped virus encoding 9860 amino acids. Coronavirus particles contain structural and non-structural proteins. The S, E, M, and N genes code for structural proteins, while the Open Frame Reading (ORF) region codes for nonstructural proteins like 3-chymotrypsin-like protease, papain-like protease, and RNA-dependent RNA polymerase. This study aimed to provide local data about SNP rs580253 and rs551684387 Casp1 genotype for Iraqi patients with various infections caused by coronavirus.

Eighty blood samples were collected between November 2020 and February 2021, with the age of patients ranging from 20 to 65 years. The sample comprised 50 patients diagnosed with COVID-19 (23 males and 27 females) from the hospitals in Baghdad, and 30 matched apparently healthy subjects as control (20 males and 10 females). All of them underwent PCR tests. The samples of 50 patients were divided into sub-groups according to the severity (mild, moderate, and severe).

The statistical analysis of rs580253 showed that there was no significant difference between control and patient groups (p-value = 0.63). The comparison between the cases, for mild, moderate and severe cases showed that there was no significant difference between cases. Also, the statistical analysis of SNP rs551684387 Casp showed that there was no significant difference between control and patient groups. The comparing between the mild, moderate, and severe cases showed no significant difference between the severity of cases.

According to our study, we thought that there is a genetic association between the SNP rs580253 Casp1 genotype, rs551684387 Casp1 genotype and the severity of infection COVID-19, and there is no genetic link between the two studied SNPs and severity of infection COVID-19.

How to cite this article:
Jabber SA, Alwan AH. The Correlation between Caspase-1 Polymorphisms and COVID-19 Severity Score of Recovered Iraqi Patients. J Commun Dis. 2021;53(4):97-103.

DOI: https://doi.org/10.24321/0019.5138.202179

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