Immunological Features of Measles in Children

  • Svetlana Chechetova Department of Children’s Infectious Diseases, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan.
  • Rahat Kadyrova Department of Children’s Infectious Diseases, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan.
  • Zuura Dzholbunova Department of Children’s Infectious Diseases, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan.
  • Elmira Mainazarova Department of Epidemiology and Immunology, Kyrgyz-Russian Slavic University, Bishkek, Kyrgyzstan.
  • Elena Khalupko Department of Children’s Infectious Diseases, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan.
  • Vityala Yethindra Department of Pathology, International Higher School of Medicine, International University of Kyrgyzstan, Bishkek, Kyrgyzstan.
  • Tugolbai Tagaev Department of Public Health and Healthcare, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan.
Keywords: Measles, Children, Clinical Course, Anergy, Lymphocytes, Immune Memory, Immunosuppression


Background: Despite the availability of a safe and effective vaccine, measles remains endemic in many countries and is the main cause of morbidity and mortality among young children. Therefore, the main objective of the study was to investigate the immunological features of measles in children.

Materials and Methods: The immune status of children (n = 72) who were diagnosed with measles, was analysed. Various lymphocyte proportions were determined using monoclonal antibodies and immunofluorescence microscopy. The immunoregulatory index was calculated.

Results: The relative content of CD4+ and CD8+ T cells in the experimental group comprising of moderately and severely ill patients was significantly lower. The immunoregulatory index was reduced, and there was a
positive correlation (0.3) between the indices during admission (2.0469 ± 0.04830) and during the entire hospital stay (1.9258 ± 0.09099) in moderately ill patients, respectively. The proportion of CD16+ T cells was higher at admission and the rate of the increase in CD16+ T cell proportion was significantly higher (P < 0.05). CD16+ counts were higher in moderate to severe cases. Thus, moderately and severely ill children with measles exhibited T-cell immune deficiency.

Conclusion: The severity of measles directly correlated with the patient age, with the disease progressing to the severe status in younger children (r = -0.3).

How to cite this article:
Chechetova S, Kadyrova R, Dzholbunova Z, Mainazarova E, Khalupko E, Vityala Y, Tagaev T. Immunological Features of Measles in Children. J Commun Dis. 2021;53(3):11-15.



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