Microbial, Immunological, and Environmental Risk Factors for Chronic Erosive-Ulcerative Gastrointestinal Tract Lesions in Children

  • Gulsara Kozhonazarova Science and analytical department, International Higher School of Medicine, Bishkek, Kyrgyzstan
  • Orozali Uzakov Science and analytical department, International Higher School of Medicine, Bishkek, Kyrgyzstan
  • Erkin Alymbaev Department of Faculty Pediatrics, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan
  • Shayirbek Sulaymanov Department of science, National Center for Maternity and Childhood Care, Bishkek, Kyrgyzstan
  • Valeria Malevannaya Department of Faculty Pediatrics, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan
  • Oksana Terekhova Department of Faculty Pediatrics, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan
  • Bermet Ongoyeva Department of Faculty Pediatrics, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan
  • Almaz Abdurakhmanov A A Department of science, National Center for Maternity and Childhood Care, Bishkek, Kyrgyzstan
  • Samat Umashev Department of Faculty Pediatrics, I.K. Akhunbaev Kyrgyz State Medical Academy, Bishkek, Kyrgyzstan
  • , Altynai Akmatova Department of science, National Center for Maternity and Childhood Care, Bishkek, Kyrgyzstan
  • Vityala Yethindra INTERNATIONAL HIGHER SCHOOL OF MEDICINE https://orcid.org/0000-0003-1007-2422
DOI: https://doi.org/10.24321/https://orcid.org/0000-0003-1007-2422
Keywords: Erosive-ulcerative lesions, gastrointestinal tract, children, helicobacter pylori, immune dysregulation, microbial factors

Abstract

Introduction: Erosive-ulcerative lesions of the gastrointestinal tract (EUL-GIT) are a growing concern in pediatric populations, particularly in low-income countries.

Aim: This retrospective study aimed to identify the risk factors contributing to EUL-GIT advancement in children, measure their predictive significance, and assess therapeutic outcomes.

Methods: The study included 2,091 children aged 0–17 years with confirmed EUL-GIT, divided into three groups: oral cavity (n=648), gastroduodenal (n=1,405), and colonic (n=38). A control group of 166 children with functional GI disorders was also assessed. Clinical evaluation, endoscopic assessment, and laboratory tests were performed. A predictive coefficient (PC) was used to evaluate the predictive value of each factor.

Results: The key predictors of oral lesions were decreased Lactobacillus spp. (PC=101.7), increased Staphylococcus spp. (PC=95.4), Clostridium spp. (PC=88.9), and Candida albicans (PC=71.0). For gastroduodenal lesions, H. pylori infection (PC=102.0), belching (PC=129.0), epigastric pain (PC=89.7), and heartburn (PC=73.1) were high predictors. In colonic lesions, H. pylori infection (PC=72.7), SIBO (PC=66.8), and elevated IL-4 (PC=68.5) were notable.

Conclusion: The PC model effectively assessed the risk and directed treatment strategies. A multidisciplinary approach involving infection management, nutritional support, and immune modulation is essential for high-risk children.

References

Zaprudnov AM, Grigoriev KI, Kharitonov LA, Bogomaz LV, Yudina TM. Problems and prospects of modern children’s gastroenterology. Pediatrics. 2016;95(6):10-.

Rasquin A, Di Lorenzo C, Forbes D, Guiraldes E, Hyams JS, Staiano A, Walker LS. Childhood functional

gastrointestinal disorders: child/adolescent. Gastroenterology. 2006 Apr 1;130(5):1527.

Published
2025-10-01
Issue
Vol. 57 No. 3 (2025): Journal of Communicable Diseases
Section
Research Article

Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138)

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