Isolation and Characterisation of Active Fungal Endophytes from Aegle marmelos and their relation to communicable skin infections

Abstract

The rising threat of communicable fungal skin infections, particularly dermatophytosis, has intensified the demand for innovative and effective therapeutic strategies. Silver nanoparticles (AgNPs) have emerged as potent antimicrobial agents with broad-spectrum activity, including against pathogenic fungi. However, conventional methods of synthesizing AgNPs often engage noxious chemicals, causing major environmental and health risks. In response, green synthesis using biological organisms, particularly endophytic fungi, has gained momentum as a sustainable and eco-friendly alternative. Endophytic fungi, which reside asymptomatically within plant tissues, possess remarkable metabolic capabilities, including the ability to reduce silver ions into stable nanoparticles. This study explores the potential of fungal endophytes and their application in the treatment of fungal skin infections. By harnessing the natural biosynthetic machinery of these fungi, it is possible to develop biocompatible nanoparticles with enhanced antifungal efficacy. The research aims to contribute to the development of safer, greener, and more effective nanotechnological approaches for managing dermatological fungal infections.