Coronaviruses: The Most Dangerous Pathogen of Present Era
Abstract
Coronaviruses are the major group of viruses belonging to the Order Nidovirales. Four families- Coronoviridae, Arteriviridae, Mesoniviridae, and Roviviridae are included in this Order. All CoVs are pleomorphic RNA viruses characterized by club-like spikes that project from their surface. These viruses have unusually large RNA genome, with a unique replication strategy. CoVs were not considered as highly pathogenic for humans until the emergence of SARS-CoV in 2002-03 in China. The emergence of another highly pathogenic CoV, Middle East Respiratory syndrome (MERS-CoV) in the Middle East Countries confirmed the occurrence of highly pathogenic human viruses among the Coronaviruses. In this article we provide a brief introduction to coronaviruses, mode of action, pathogenesis, current situation, prevention and control of COVID-19.
How to cite this article:
Rajendran R, Sheela Devi D, Anusree SB, Regu K, Sharma SN. Coronaviruses: The Most Dangerous Pathog, en of Present Era. J Commun Dis 2020; 52(4): 17-28.
DOI: https://doi.org/10.24321/0019.5138.202036
References
Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. Methods Mol Biol
; 1282: 1-23.
de Groot RJ, Baker SC, Baric R et al. Family Coronaviridae. In: King AMQ, Lefkowitz E, Adams MJ (eds.). Ninth
Report of the International Committee on Taxonomy of Viruses. Elsevier, Oxford. pp. 806-828.
Corman VM, Muth D, Niemeyer D et al. Hosts and sources of endemic human coronaviruses. Advances
in Virus Research 2018; 100: 163-188.
Jia HP, Look DC, Shi L et al. ACE2 receptor expression and severe acute respiratory syndrome coronavirus
infection depend on differentiation of human airway epithelia. J Virol 2005; 79: 14614-21.
Beaudette F, Hudson C. Cultivation of the virus of infectious bronchitis. J Am Vet Med Assoc 1937; 90:
-8.
Ananthanarayan R, Jayaram Paniker CK. Textbook of Microbiology, Fifth Edition, Orient Longman Ltd., 1998.
Saif LJ. Animal coronaviruses: what can they teach us about the severe acute respiratory syndrome? Rev Sci
Tech 2004; 23: 643-660.
Lai MM. RNA recombination in animal and plant viruses. Microbiol Rev 1992; 56: 61-79.
Plowright RK, Eby P, Hudson PJ et al. Ecological dimensions of dynamics of emerging bat virus spillover.
Proc Biol Sci 2015; 282: 20142124.10. Yadav PD, Shete AM, Kumar GA et al. Nipah virus sequences from humans and bats during Nipah outbreak, Kerala, India, 2018. Emerg Infect Dis 2019; 25: 1003-6.
Yadav PD, Shete A, Dimpal A et al. Detection of coronaviruses in Pteropus & Rousettus species of bats
from different states of India. Indian J Med Res. 2020.
Hamre D, Procknow JJ. A new virus isolated from the human respiratory tract. Proc Soc Exp Biol Med 1966;
: 190-3.
McIntosh K, Dees JH, Becker WB et al. Recovery in tracheal organ cultures of novel viruses from patients
with respiratory diseases. Proc Natl Acad Sci U.S.A. 1967; 57: 933-940.
Richard SD. Responding to global infectious disease outbreaks: Lessons from SARS on the role of risk
perception, communication and management. Social Science and Medicine 2006; 63(12): 3113-23.
Lau SKP, Woo PCY, Li KSM et al. Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proc Natl Acad Sci 2005; 102(39): 14040-5.
Li W, Zhengl S; Meng Y et al. Bats are Natural reservoirs of SARS-like Coronaviruses. Science 2005; 310(5748):
-9.
Zaki AM, van Boheemen S, Bestebroer TM et al. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med 2012; 367: 1814-20.
The Economic Times. A Wuhan shrimp seller identified as coronavirus ‘patient zero’. 2020.
Lu H, Tang CW, Tang Y. Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and
the miracle. J Medl Virol 2020.
Shi Z, Hu Z. A review of studies on animal reservoirs of SARS coronavirus. Virus Res 2008: 133(1): 74-87.
Wang N, Shi X, Jiang L et al. Structure of MERS-CoV spike receptor-binding domain complexed with human
receptor DPP4. Cell Res 2013; 23(8): 986.
Li B, Si HR, Zhu Y et al. Discovery of Bat Coronaviruses through surveillance and Probe Capture- Based Next
Generation Sequencing. Insphere 2020: 5(1).
Shereen MA, Khan S, Kazmi A et al. COVID-19 infection: Origin, transmission and characteristics of human
coronaviruses. Journal of Advanced Research 2020; 24: 91-8.
WHO. Coronavirus Disease 2019 (COVID-19) Situation Report-49. 2020.
WHO. Coronavirus disease (COVID-19) Situation Report-152. 2020
MH & FW. COVID-19 State-wise Status, Ministry of Health and Family Welfare, Government of India, 2020
Arunkumar G, Chandini R, Mourya DT et al. Nipah Investigators and Health Study Group. Outbreak
Investigation of Nipah virus Disease in Kerala, India, 2018. The Journal of Infectious Diseases 2019; 219(12):
-78.
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