Haematological and Biochemical Parameters in COVID-19 Patients Attending a Tertiary Care Hospital: A Retrospective Study

Anita Omhare; Shilpi Singh; Suresh Kumar Yadav; Kiran Yadav; Sachin Chaudhary; Kanhaiya Lal Mishra

Anita Omhare Associate Professor, Department of Pathology, Dr Bhimrao Ramji Ambedkar Government Medical College, Kannauj, Uttar Pradesh, India
Shilpi Singh Associate Professor, Department of Pathology, Dr Bhimrao Ramji Ambedkar Government Medical College, Kannauj, Uttar Pradesh, India
Suresh Kumar Yadav Associate Professor, Department of Pediatrics, Hind Institute Of Medical Sciences, Ataria, Sitapur, Uttar Pradesh, India
Kiran Yadav Associate Professor, Department of Microbiology, Dr Bhimrao Ramji Ambeadkar Government Medical College, Kannauj, Uttar Pradesh, India
Sachin Chaudhary Assistant Professor, Department of Community Medicine, Autonomous State Medical College, Shahjahanpur, Uttar Pradesh, India
Kanhaiya Lal Mishra Assistant Professor, Department of Pathology, Dr Bhimrao Ramji Ambedkar Government Medical College, Kannauj, Uttar Pradesh, India

Abstract

Introduction: The SARS-CoV-2 RNA virus, which causes COVID-19
disease, rapidly spread to the entire world. COVID-19 mainly involves the
respiratory tract, now found to be linked with systemic diseases due to
multiple organ involvement. Limited data are available regarding the effect
of COVID-19 on various haematological and biochemical parameters.
Materials and Methods: A retrospective cross-sectional study was carried
out on 400 cases from March 2021 to August 2021. Two hundred
COVID-19 RT-PCR confirmed cases formed the study group and 200
subjects who tested negative were included in the controls to study
various haematological and biochemical parameters.
Results: Thrombocytopenia was significantly noticed in cases as compared
to controls (65.3% and 34.7%, respectively), with cases 2.45 times more
likely to be thrombocytopenic (p < 0.01). Leucopenia was 1.79 times
higher in cases (62.8%) in comparison to controls (37.2%). Moreover,
positive cases were 1.35 times more anaemic than control. The mean
indices for serum bilirubin (p = 0.020), serum creatinine (p < 0.001),
alanine transaminase (p = 0.081), blood urea (p < 0.001), procalcitonin
(p < 0.001) and c-reactive protein (p < 0.001) were significantly raised
in cases in comparison to controls.
Conclusion: Thrombocytopenia, leucopenia along with raised serum
bilirubin, creatinine, ALT, AST, CRP and procalcitonin may be beneficial
in the diagnosis of COVID-19. Meticulous assessment and correlation of
haematological and biochemical parameters at the time of admission and
simultaneously during the disease course will be helpful to physicians
in formulating individualised treatment along with decision-making
regarding requiring intensive care to those in need.

How to cite this article:
Omhare A, Singh S, Yadav S K, Yadav K, Chaudhary
S, Mishra K L. Haematological and Biochemical
Parameters in COVID-19 Patients Attending a
Tertiary Care Hospital: A Retrospective Study. J
Commun Dis. 2025;57(1):115-120.

DOI: https://doi.org/10.24321/0019.5138.202515

Author Biography

Anita Omhare, Associate Professor, Department of Pathology, Dr Bhimrao Ramji Ambedkar Government Medical College, Kannauj, Uttar Pradesh, India

DEPT. OF PATHOLOGY

DR BHIMRAO RAMJI AMBEDKAR GOVERNMENT MEDICAL COLLEGE

KANNAUJ – 209732

UTTAR PRADESH, INDIA

Contact- 9651719041

References

Worldometer [Internet]. COVID Live Update:

,434,019 cases and 4,168,834 deaths from the

Coronavirus; [cited 2024 Jan 11]. Available from:

https://www.worldometers.info/coronavirus/

Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao

X, Huang B, Shi W, Lu R, Niu P, Zhan F, Ma X, Wang D,

Xu W, Wu G, Gao GF, Tan W; China Novel Coronavirus

Investigating and Research Team. A novel coronavirus

from patients with pneumonia in China, 2019. N Engl

J Med. 2020;382:727-33. [PubMed] [Google Scholar]