Evaluation of Treatment Outcomes in Shorter and Longer Regimen Treatment in Multi-Drug Resistant Tuberculosis (MDR-TB) Patients in District Etawah: A Longitudinal Study

Rahul Verma; Dhiraj Kumar Srivastava; Sandip Kumar; Mohit Mishra; Alankrita Acharya; Ankur Baidya

Rahul Verma Senior Resident, Department of Community Medicine, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India
Dhiraj Kumar Srivastava Professor, Department of Community Medicine, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India
Sandip Kumar Professor, Department of Community Medicine, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India
Mohit Mishra Assistant Professor, Department of Community Medicine, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India
Alankrita Acharya Senior Resident, Department of Community Medicine, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India
Ankur Baidya Junior Resident, Department of Community Medicine, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, India

Abstract

Background: Multi-drug resistance tuberculosis is a worldwide problem with a notoriously difficult and challenging treatment. There are two treatment regimens for MDR-TB treatment.

Objectives: To compare the predisposing risk factors and treatment outcomes in two different drug regimens for the treatment of MDR-TB.

Material and methods: A field based longitudinal study was carried out among 50 microbiologically confirmed MDR-TB patients of age 18 years and above, enrolled from January 2020 to December 2020 of district Etawah. Variables recorded were socio-demographics, clinical profile and treatment outcomes.

Result: Mean age of the participants was 30.70±12.52 years. Most of the participants were female (58%) and belonged to Class II and III of Modified BG Prasad Classification. Most of the participants (62%) had BMI of <18.5Kg/m². About 93% of the study participants in the shorter regimen completed the treatment and were cured. The participants with no prior history of tuberculosis had better treatment outcome (p=<0.001).

Conclusion: The present study concludes that successful treatment outcome is more in shorter treatment regimen compared to longer treatment regimen.

Keywords: MDR-TB, shorter regimen, longer regimen, treatment outcomes, NTEP, India

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