A Complex Infectious Case of Dengue Fever with Thrombocytopenia, Acute Hepatitis A, Influenza B, URTI(Upper Respiratory Tract Infection), and Secondary HLH (Hemophagocytic Lymphohistiocytosis): A Diagnostic Challenge

Abstract

Worldwide, dengue is the most frequent trigger for viral haemorrhagic
fever. Although it is chronic in many tropical nations, instances from
non-endemic areas have also been documented on a regular basis in
recent years. Nonetheless, the World Health Organization’s revised
classification of dengue splits it into three groups: severe dengue,
dengue with warning signals, and dengue without warning signs.
Significant dengue is defined as those who have a significant vascular
leak, hypotension, severe bleeding, or severe organ involvement.
Hepatitis, the influenza virus, respiratory infections, liver failure, and
Hemophagocytic lymphohistiocytosis (HLH) linked to dengue fever
have all been documented; most of these cases involved children, with
a small number of adult case reports. Fatal results including a 50%
mortality rate have been documented in the child’s research. Here we
have presented a case of a 17-year-old teenager with dengue fever and
co-morbidities of hepatitis, influenza, lung diseases, and HLH.

How to cite this article:
Gadhiya H, Radhanpura Y, Parekh K, Trigar P.
A Complex Infectious Case of Dengue Fever
with Thrombocytopenia, Acute Hepatitis A,
Influenza B, URTI(Upper Respiratory Tract
Infection), and Secondary HLH (Hemophagocytic
Lymphohistiocytosis): A Diagnostic Challenge. J
Commun Dis. 2025;57(1):213-216.

DOI: https://doi.org/10.24321/0019.5138.202527