Revolutionising HIV Care: Emerging Strategies and Therapeutic Breakthroughs - A Literature Review

  • Akhil Arun Faculty Lecturer, Department of Pharmacy Practice, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
  • Jessica Mary Nobby PharmD Student, Department of Pharmacy Practice, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
  • Sneha Mohen PharmD Student, Department of Pharmacy Practice, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
  • Devika Suresh Nair PharmD Student, Department of Pharmacy Practice, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
  • Rajalakshmi S PharmD Student, Department of Pharmacy Practice, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
  • Lakshmi Menon
Keywords: HIV, Pharmacotherapy, Anti-viral Medication, Novel Therapy, HIV-AIDS

Abstract

HIV-AIDS is a globally prevalent disease largely managed by the use of anti-retroviral therapy, however, during the treatment, a significant proportion of patients experience various drug-induced toxicities, thus causing failure to comply with the treatment regimen. With recent advancements in the field of medicine and HIV care many new and effective treatment modalities have surfaced and have been tested on humans giving promising results with a very significant reduction in the viral load. Given that millions of people worldwide are affected by
HIV it is crucial now more than ever to explore innovative approaches. Our review paper delves into providing strong evidence based on existing literature of new emerging drugs as well injectables that cater to the needs of the patient and help in improving adherence to therapy. Cutting-edge genetic techniques such as gene editing and monoclonal antibodies are also highlighted as methods with the potentialto eliminate HIV atits core. Asresearch advancesthe collective efforts of researchers and healthcare professionals provide hope for
a future where HIV is no longer a disease. This review emphasises the importance of research and innovation in our fight, against HIV and our pursuit of a cure.

How to cite this article:
Arun A, Nobby J M, Mohen S, Nair D S,
Rajalakshmi S, Menon L. Revolutionising HIV
Care: Emerging Strategies and Therapeutic
Breakthroughs- A Literature Review. J Commun
Dis. 2024;56(3):172-188.

DOI: https://doi.org/10.24321/0019.5138.202461

References

Joint United Nations Programme onHIV/AIDS [Internet]. Factsheet - latest global and regionalstatistics on the

status of the AIDS epidemic; 2024 Jul 22 [cited 2024 Sep 5]. Available from: https://www.unaids.org/en/ resources/documents/2023/UNAIDS_FactSheet

Montessori V, Press N, Harris M, Akagi L, Montaner JS. Adverse effects of antiretroviral therapy for HIV infection. CMAJ. 2004 Jan 20;170(2):229-38. [PubMed] [Google Scholar]

Chary A, Nguyen NN, Maiton K, Holodniy M. A review of drug-drug interactionsin older HIV-infected patients.

Expert Rev Clin Pharmacol [Internet]. 2017 Dec 2 [cited 2024 Mar 5];10(12):1329-52. Available from: https://doi.org/10.1080/17512433.2017.1377610 [PubMed] [Google Scholar]

National Library of Medicine. Woman potentially cured of HIV using transplant with cord blood stem cells [Internet]. NIH Research Matters; 2023 Apr 4 [cited 2024 May 5]. Available from: https://www.ncbi.nlm. nih.gov/search/research-news/18597/

Hussein M, Molina MA, Berkhout B, Herrera-Carrillo E. A CRISPR-Cas cure for HIV/AIDS. Int J Mol Sci [Internet].

Jan [cited 2024 Mar 5];24(2):1563. Available from: https://www.mdpi.com/1422-0067/24/2/1563 [PubMed] [Google Scholar]

Williams N. Recent advancements in treating HIV [Internet]. News-Medical; 2022 [cited 2024 Mar 5]. Available from: https://www.news-medical.net/health/ Recent-Advancements-in-Treating-HIV.aspx

Published
2024-10-08