Correlation between IL-10 and IL-23 Levels and Aerobic and Anaerobic Bacteria Isolated from Diabetic Foot Ulcer Patients in Mosul City

Rana Ibrahim Khalil; Saria Naji Mohsi; Sura Hameed Nayyef

Rana Ibrahim Khalil Al-salam Teaching Hospital/Nineveh Health Department, Nineveh, Iraq, Department of Biology, Collage of Science, Tikrit University, Salah AL-Din, Iraq.
Saria Naji Mohsi Department of Biology, College of Science, Tikrit University, Salah AL-Din, Iraq.
Sura Hameed Nayyef Department of Biology, College of Science, Tikrit University, Salah AL-Din, Iraq.

Keywords: T2DM, Diabetic Foot, IL-10, IL-23, Antibiotics

Abstract

Introduction: The occurrence of Foot ulcers among diabetes Mellitus
is a common complication and its prevention is of utmost importance.
Aims: To find a relationship between the levels of interleukins 10 and
23 and the bacterial species isolated from diabetic foot ulcer patients
to identify the antibiotics used to treat the ulcers the bacterial species
that are resistant to antibiotics. Methodology The study was conducted
at Al-Salam Teaching Hospital in the city of Mosul during the period
from December 1, 2022 to the end of June 2023. The study included
65 samples from patients between the ages of 35 and 80 years.

Results: Of 65 participants, there were 40 males and 25 females , re-
vealing a significantly higher incidence of diabetic foot ulcers in males

compared to females in cases of type 2 diabetes. The investigation in-
cluded an evaluation of IL-10 and IL-23 levels and the results showed no

significant difference in the IL-23 levels between patients and controls,
while significant negative differences in IL-10 levels were observed.
The results of antibiotic susceptibility tests conducted on diabetic foot
ulcer isolates showed the presence of bacteria at the site of diabetic
ulcers that were resistant to multiple antibiotics.
Conclusion: We conclude from this study that there is a relationship

between the levels of IL -10 and IL 23 and the increase in the devel-
opment of inflammation in diabetic foot ulcer patients. It was seen

that there are bacterial species that are resistant to antibiotics. The
development of a new drug is needed to treat bacterial infections in
antibiotic-resistant diabetic foot ulcer patients.

How to cite this article:
Khalil R I, Mohsi S N, Nayyef, S H. Correlation
between IL-10 and IL-23 Levels and Aerobic
and Anaerobic Bacteria Isolated from Diabetic
Foot Ulcer Patients in Mosul City. J Commun Dis.
2024;56(4):177-183.

DOI: https://doi.org/10.24321/0019.5138.202490

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