Estimation of lL-6 and IL-17A Levels in Bacterial Isolates from Sinusitis Patients attending a hospital in lraq

Abstract

Background: Sinusitis are highly prevalent diseases and significantly impair life of patients. Viral and bacterial acute sinusitis are common occurrence with morbidity and serious complications.
Methods: The study involved collection of 150 nasal swabs and blood specimens from patients of both genders with different age groups attending Balad General Hospital and primary health centres from November 2022 to June 2023 in lraq.The diagnosis relied on differential mediator for bacterial identification, biochemical tests, and Vitek device. Elisa technique was used to estimate the immune marker; all data were analysed using SPSS and presented with tables and figures indicating statistical association at 5% error.
Results: Sample showed Escherchia coli, Staphylococcus haemolyticus, Klebsiella pneumoniae, Yersinia enterocolitica, Providencia stuartii, Staphylococcus epidermidis, Pseudomonas oryzihabitans, Leuconostoc
pseudomesenteroides, and Burkholderia cepacia. Age groups of 21 30 and 31-40 years showed high prevalence of sinusitis .Levels of interleukins IL-6 and IL-17A were also measured .Mean levels of IL-6 and IL-17A were higher in patients (88.08 ± 33.00 and 231.62 ± 101.00) than in controls (40.46 ± 13.27 and 127.35 ± 52.00). respectively.The comparison of IL-6 and IL-17A with respect to bacterial species showed a significant difference between IL-6 and E. coli obtained from the same patient, as compared to patients without this isolate.
Conclusion: Despite the isolation of uncommon bacterial pathogens; Staphylococci spp.remains the predominant bacteria. the results revealed that IL-17A showed high sensitivity and specificity in examining
patients with sinusitis as compared to IL-6, which showed moderate sensitivity and specificity However,further , studies are needed to confirm these findings .

How to cite this article:
Kazem S N A, Rashid S A, Mahmoud M H, Mohsen A A S. Estimation of lL-6 and IL-17A Levels in Bacterial Isolates from Sinusitis Patients attending a hospital in lraq. J Commun Dis. 2025;57(3):96-102.

DOI: https://doi.org/10.24321/0019.5138.202573