Assessment of the Levels of TGF-beta1 and IL-18 in Gastritis Patients Infected with Helicobacter pylori

  • Ahoodabd Alhussen Habeeb Salah Al-Din Health Department, Balad General Hospital.
  • Halah Abdulkhaliq Awadh Department of Biology, College of Sciences, Tikrit University, Tikrit.
  • Firas Fairs Rija Department of Biology, College of Sciences, Tikrit University, Tikrit.
Keywords: IL-18, H. pylori, Gastritis


Background: Gastritis is characterised as an inflammation of the gastric mucosa, the stomach’s protective lining, and is divided into two categories: acute and chronic, depending on the severity of the inflammation and the disease’s history. This study aims to estimate the levels of transforming growth factor-beta 1 (TGF-Beta1) and interleukin-18 (IL-18) in gastritis patients infected with Helicobacter pylori.

Material and Method: From September 2022 to June 2023, a cross- sectional study was conducted in the General Hospital and at various private clinics in Balad City, Iraq. Eighty-nine samples (50 patients and 39 healthy individuals as control) were collected from 42 males and 47 females aged 15–85 years from Balad General Hospital, and private upper surgical endoscopy clinic. Blood, stool, and biopsy samples were collected from individuals suffering from complaints such as loss of appetite, weight loss, diarrhoea, vomiting, and dyspepsia.

Conclusion: IL-18 and TGF-Beta1 levels were elevated in the serum of people with gastritis H. pylori infection in this study as compared to the healthy groups. A correlation was found between TGF-Beta1 and IL-18 serum levels in relation to H. pylori and bacterial infection.


Azer SA, Awosika AO, Akhondi H. Gastritis. 2021 Jul 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2021 [cited 2023 Jul 21]. Available from:


Hassuna NA, Hussien SS, Abdelhakeem M, Aboalela A, Ahmed E, Abdelrahim SS. 2023. Regulatory B cells (Bregs)

in Helicobacter pylori chronic infection. Helicobacter.

;28(2):e12951. [PubMed] [Google Scholar]

Soares GA, Moraes FA, Ramos AF, Santiago SB,

Germano JN, Fernandes GA, Curado MP, Barbosa MS. 2023. Dietary habits and Helicobacter pylori infection: is there an association? Therap Adv Gastroenterol. 2023;16:17562848231160620. [PubMed] [Google Scholar]