Enhancement of Swarming and Inhibition of Prodigiosin in Serratia marcescens by Glyceryl Trinitrate

  • Ziyad Hameed Al-Fayyadh Department of Biology-College of Science, University of Anbar.
  • Ahmed Mohammed Turki Department of Biology-College of Science, University of Anbar.
  • Harith Jabbar Fahad Al-Mathkhury Department of Biology-College of Science, University of Baghdad, Baghdad, Iraq.
Keywords: rssB, rsmA, pigP, Repurposing, Glyceryl trinitrate, Serratia marcescens


Introduction: Serratia marcescens is a gram-negative pathogen of many species. Its pathogenicity and survival are linked to its capacity to build biofilms as well as its strong inherent resistance to antimicrobials and cleaning agents.

Objectives: To analyse the impact of glyceryl trinitrate (GTN) on the gene expression of QS-related genes (rssB, rsmA, and pigP) of S. marcescens.

Methodology: The broth microdilution technique estimated the bactericidal effectiveness of glyceryl trinitrate. The presence of rssB, rsmA, and pigP in S. marcescens isolates was detected using PCR. qRT-PCR was used to assess the effect of GTN on rssB, rsmA, and pigP gene expression.

Results: The results demonstrated that GTN has no effect on S. marcescens growth. Furthermore, rssB, rsmA, and pigP were located in all S. marcescens isolates and their gene expression was downregulated due to GTN presence.

Conclusion: GTN can act as a promising anti-quorum sensing agent in reference to S. marcescens.

How to cite this article:
Al-Fayyadh ZH, Turki AM, Al-Mathkhury HJF. Enhancement of Swarming and Inhibition of Prodigiosin in Serratia marcescens by Glyceryl Trinitrate. J Commun Dis. 2023;55(1):30-35.

DOI: https://doi.org/10.24321/0019.5138.202305


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