Oesophageal and Oral Ulcer Tuberculous Associated with Human T-cell Lymphotropic Virus Type 1 (HTLV-1) and SARS-COV-2 Infection

Raul Montalvo; Pierina Vilcapoma; Manuel Pomazongo; Cecilia Mathey; Miguel Montalvo

Raul Montalvo Universidad Nacional del Centro del PerÃº.
Pierina Vilcapoma Universidad Continental, PerÃº.
Manuel Pomazongo Faculty of Medicine, Daniel Alcides Carrion National University, Cerro de Pasco, Peru.
Cecilia Mathey Faculty of Medicine, Daniel Alcides Carrion National University, Cerro de Pasco, Peru.
Miguel Montalvo Universidad Peruana Los Andes.

Keywords: Tuberculosis, Oesophageal Ulcer, SARS-COV-2, COVID-19, HTLV-1

Abstract

Oesophageal involvement due to tuberculosis (TB) and coinfection with HTLV-1 is rare and can be complicated by the presence of other infections that affect the mucosa of the upper respiratory tract, such as COVID-19. We present the case of a 27-year-old male patient, with 3 months of illness, weight loss, dysphagia, and ulcers in the oral cavity. Tomography showed oesophageal perforation and after oesophageal ulcer biopsy, TB was diagnosed, in addition to infection by HTLV-1 and severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). The patient responded satisfactorily to antituberculous treatment and corticosteroids. Considering the association between rare extrapulmonary tuberculosis and other immunosuppressive pathologies, it is crucial to identify these pathologies in such patients.

How to cite this article:
Montalvo R, Vilcapoma P, Pomazongo M, Mathey C, Montalvo M. Oesophageal and Oral Ulcer Tuberculous Associated with Human T-cell Lymphotropic Virus Type 1 (HTLV-1) and SARS-COV-2 Infection. J Commun Dis. 2023;55(1):78-81.

DOI: https://doi.org/10.24321/0019.5138.202312

References

Menzies NA, Wolf E, Connors D, Bellerose M, Sbarra AN, Cohen T, Hill AN, Yaesoubi R, Galer K, White PJ, Abubakar I, Salomon JA. Progression from latent infection to active disease in dynamic tuberculosis transmission models: a systematic review of the validity of modelling assumptions. Lancet Infect Dis. 2018;18(8):e228-38. [PubMed] [Google Scholar]

Wang W, Chen JY, Chen YK, Lin LM. Tuberculosis of the head and neck: a review of 20 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107(3):381-6. [PubMed] [Google Scholar]

Rojas CL, Polanco EC, Vivar MC, Aguayo WG, Molina GA, Gutierrez BM, Cobo MM. Abdominal tuberculosis in Ecuador, a problem that is still not solved. J Clin Tuberc Other Mycobact Dis. 2020 Jun 23;20:100172. [PubMed] [Google Scholar]

Kim SY, Byun JS, Choi JK, Jung JK. A case report of a tongue ulcer presented as the first sign of occult tuberculosis. BMC Oral Health. 2019;19(1):67. [PubMed] [Google Scholar]

Rivas N, Espinoza M, Loban A, Luque O, Jurado J, Henry-Hurtado N, Goodridge A. Case Report: COVID-19 recovery from triple infection with Mycobacterium tuberculosis, HIV, and SARS-CoV-2. Am J Trop Med Hyg. 2020;103(4):1597-9. [PubMed] [Google Scholar]

Montalvo R, RamÃrez MC, DamiÃ¡n M, Bruno A, Vilchez S, Quisurco M. [Unusual presentation of HTLV-1 infection: a pandoraâ€™s box of opportunistic infections]. Rev Argent Dermatol [Internet]. 2018 [cited 2023 Jan 28];99(2):1-10. Available from: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1851-300X2018000200006&lng=es. Spanish.

Lopinto J, Teulier M, Milon A, Voiriot G, Fartoukh M. Severe hemoptysis in post-tuberculosis bronchiectasis precipitated by SARS-CoV-2 infection. BMC Pulm Med. 2020 Sep 14;20(1):244. [PubMed] [Google Scholar]

World Health Organization [Internet]. Global tuberculosis report 2021; 2021 [cited 2022 Sep 28]. p. 7-21. Available from: https://www.who.int/publications/i/item/9789240037021

Carvalho NB, de Lourdes Bastos M, Souza AS, Netto EM, Arruda S, Santos SB, Carvalho EM. Impaired TNF, IL-1Î², and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individuals. Tuberculosis (Edinb). 2018 Jan;108:35-40. [PubMed] [Google Scholar]

Jiang S, Liu P, Xiong G, Yang Z, Wang M, Li Y, Yu XJ. Coinfection of SARS-CoV-2 and multiple respiratory pathogens in children. Clin Chem Lab Med. 2020 Jun 25;58(7):1160-1. [PubMed] [Google Scholar]

Montalvo R, Rodriguez-Mori D, Fredes-Pasaca G. [Lingual ulcer as a manifestation of systemic paracoccidioidomycosis. Case report]. Rev Chilena Infectol. 2020 Jun;37(3):313-5. Spanish. [PubMed] [Google Scholar]

Xiong J, Guo W, Guo Y, Gong L, Liu S. Clinical and endoscopic features of esophageal tuberculosis: a 20-year retrospective study. Scand J Gastroenterol. 2020;55(10):1200-4. [PubMed] [Google Scholar]

Zhu R, Bai Y, Zhou Y, Fang X, Zhao K, Tuo B, Wu H. EUS in the diagnosis of pathologically undiagnosed esophageal tuberculosis. BMC Gastroenterol. 2020 Aug 28;20(1):291. [PubMed] [Google Scholar]

Kentley J, Ooi JL, Potter J, Tiberi S, Oâ€™Shaughnessy T, Langmead L, Aleong JC, Thaha MA, Kunst H. Intestinal tuberculosis: a diagnostic challenge. Trop Med Int Health. 2017;22(8):994-9. [PubMed] [Google Scholar]

Marimuthu J, Kumar BS, Gandhi PA. HIV and SARS CoV-2 co-infection: a retrospective, record-based, case series from South India. J Med Virol. 2021 Jan;93(1):163-5. [PubMed] [Google Scholar]