Breastfeeding: Importance in Early Development of the Immune System and Long-term Health


  • Usha Rani Sister Tutor, Ahilya Bai College of Nursing, Lok Nayak Hospital & MAM College, New Delhi, India.
  • Maharaj Singh Professor & Research Head, NIMS, Jaipur, India
  • Sher Singh Kashyotia Additional Director & Incharge Polio Cell, Directorate of Family Welfare, GNCT of Delhi, India
Keywords: Breastfeeding, Breast Milk, Immune System, Development


Breastfeeding supplies the baby and infant with unparalleled natural nutrients. Human breast milk also has several antimicrobial agents and may influence immune system development, as evidenced by prior research on newborn immunisation response and thymus gland development.

Human milk is a dynamic supply of nutrients and bioactive ingredients and promotes the healthy growth and development of the human newborn. Infants are more susceptible to infection because their developing immune systems have a number of weaknesses. This review focuses on the direct effect of human milk on innate immunity in infants. Numerous new studies have made the multi-functionality of the bioactive components of human milk very clear. Our knowledge of the potential positive effects of human milk on infants has increased. These effects are not achievable with milk formulae.

Human milk contains antimicrobial proteins and peptides that have a broader involvement in innate immune defence than previously thought. A complex combination of the anti-inflammatory and antioxidative substances that human milk supplies to the intestine results in a special environment of improved immune defence with reduced inflammation.

How to cite this article:
Rani U, Singh M, Kashyotia SS. Breastfeeding: Importance in Early Development of the Immune System and Long-term Health. J Commun Dis. 2022;54(2):107-109.


Author Biography

Usha Rani, Sister Tutor, Ahilya Bai College of Nursing, Lok Nayak Hospital & MAM College, New Delhi, India.



Howie PW, Forsyth JS, Ogston SA, Clark A, Florey CD. Protective effect of breast feeding against infection.

BMJ. 1990;300:11-6. [PubMed] [Google Scholar]

Bartels M, van Beijsterveldt CE, Boomsma DI. Breastfeeding, maternal education and cognitive

function: a prospective study in twins. Behav Genet. 2009;39:616-22. [PubMed] [Google Scholar]

Bhandari N, Bahl R, Mazumdar S, Martines J, Black RE, Bhan MK; Infant Feeding Study Group. Effect of

community-based promotion of exclusive breastfeeding on diarrhoeal illness and growth: a cluster randomised

controlled trial. Lancet. 2003; 361:1418-23. [PubMed] [Google Scholar]

Anderson JW, Johnstone BM, Remley DT. Breast-feeding and cognitive development: a meta-analysis. Am J Clin

Nutr. 1999;70:525-35. [PubMed] [Google Scholar]

Kramer MS, Aboud F, Mironova E, Vanilovich I, Platt RW, Matush L, Igumnov S, Fombonne E, Bogdanovich

N, Ducruet T, Collet JP, Chalmers B, Hodnett E, Davidovsky S, Skugarevsky O, Trofimovich O, Kozlova

L, Shapiro S; Promotion of Breastfeeding Intervention Trial (PROBIT) Study Group. Breastfeeding and child

cognitive development: new evidence from a large randomized trial. Arch Gen Psychiatry. 2008;65:578-84.

[PubMed] [Google Scholar]

Jedrychowski W, Perera F, Jankowski J, Butscher M, Mroz E, Flak E, Kaim I, Lisowska-Miszczyk I, Skarupa

A, Sowa A. Effect of exclusive breastfeeding on the development of children’s cognitive function in the

Krakow prospective birth cohort study. Eur J Pediatr. 2012;171:151-8. [PubMed] [Google Scholar]

Jacobson SW, Chiodo LM, Jacobson JL. Breastfeeding effects on intelligence quotient in 4- and 11-year-old

children. Pediatrics. 1999;103:e71. [PubMed] [Google Scholar]

Riordan J, Wambach K. Child health: theories of development. In: Breastfeeding and human lactation.

th ed. Burlington, MA: Jones & Bartlett Learning; 2014; 679