An Overview of Ondine’s Curse and its Diagnostic Options in the Medical Field
Abstract
One of the most captivating mythical tales in the realm of medicine is Ondine’s curse. Ondine was an eternal water spirit who became human after falling in love, marrying, and having a child with a man. When she saw her husband sleeping with another woman, she cursed him to stay awake to control his breathing, according to one version of the story. The unusual illness marked by loss of autonomic breath control while voluntary breathing remains intact was cleverly called “Ondine’s curse†during the nineteenth century. Nowadays, Ondine’s curse is most commonly connected with congenital central hypoventilation syndrome; nevertheless, it is also used to describe a variety of respiratory illnesses in the medical literature.
How to cite this article:
Kelvin M. An Overview of Ondine’s Curse and its Diagnostic Options in the Medical Field. J Commun Dis. 2022;54(2):89-94.
DOI: https://doi.org/10.24321/0019.5138.202276
References
Auer RN, Rowlands CG, Perry SF, Remmers JE. Multiple sclerosis with medullary plaques and fatal sleep apnea
(Ondine’s curse). Clin Neuropathol. 1996 Mar;15(2):101-5. [PubMed] [Google Scholar]
Barone DA, Chokroverty S. Neurologic diseases and sleep. Sleep Med Clin. 2017 Mar;12(1):73-85. [PubMed]
[Google Scholar]
Chen ML, Turkel SB, Jacobson JR, Keens TG. Alcohol use in congenital central hypoventilation syndrome.
PediatrPulmonol. 2006 Mar;41(3):283-5. [PubMed] [Google Scholar]
Chen ML, Tablizo MA, Kun S, Keens TG. Diaphragm pacers as a treatment for congenital central hypoventilation syndrome. Expert Rev Med Devices. 2005;2(5):577-85. [PubMed] [Google Scholar]
Valika T, Chin AC, Thompson DM, Kabre R, Lavin JM, Neault SH, Ballard HA, Kenny AS, Weese-Mayer DE.
Airway obstruction during sleep due to diaphragm pacing precludes decannulation in young children
with CCHS. Respiration. 2019;98(3):263-7.[PubMed] [Google Scholar]
Fujisawa H, Yoshida Y, Niida Y, Hasegawa M, Yamashita J. Cyanotic breath-holding spell: a lifethreatening complication after radical resection of a cervicomedullary ganglioglioma. PediatrNeurosurg.
;41(2):93-7. [PubMed] [Google Scholar]
Gaultier C, Amiel J, Dauger S, Trang H, Lyonnet S, Gallego J, Simonneau M. Genetics and early disturbances of
breathing control: the genetics of childhood disease and development: a series of review articles. Pediatr
Res. 2004 May;55(5):729-33. [Google Scholar]
Gaultier C, Trang H, Dauger S, Gallego J. Pediatric disorders with autonomic dysfunction: what role
for PHOX2B? Pediatr Res. 2005;58(1):1-6. [PubMed] [Google Scholar]
Gozal D. Congenital central hypoventilation syndrome: an update. PediatrPulmonol. 1998 Oct;26(4):273-82.
[PubMed] [Google Scholar]
Gross A, KÅ‚ys M. [Suicide by propane-butane inhalation: a case report and literature review]. Arch
Med SadowejKryminol. 2002 Jan;52(1):37-42. Polish. [PubMed] [Google Scholar]
Gupta R, Oh U, Spessot AL, Anderson RC, Kaiser MG, Fitzsimmons BF. Resolution of Ondine’s curse after
suboccipital decompression in a 72-year-old woman. Neurology. 2003;61(2):275-6. [PubMed] [Google
Scholar]
Hamilton J, Bodurtha JN. Congenital central hypoventilation syndrome and Hirschsprung’s disease
in half sibs. J Med Genet. 1989;26(4):272. [PubMed] [Google Scholar]
Ishibashi H, Umezawa K, Hayashi S, Shibutani K. Anesthetic management of a child with congenital
central hypoventilation syndrome (CCHS, Ondine’s curse) for dental treatment. Anesth Prog. 2004;51(3):102.
[PubMed] [Google Scholar]
Juan G, Ramón M, Cisca, MA, GarcÃa B, Lloret T, Cervelló MA, MarÃn J.Insuficiencia respiratoria
agudacomoprimeramanifestacion de lesiones del tronco cerebral. Arch Bronconeumol. 1999;35:560-3.
Spanish. [Google Scholar]
Kapnadak SG, Mikolaenko I, Enfield K, Gress DR, Nathan BR. Ondine’s curse with accompanying trigeminal and glossopharyngeal neuralgia secondary to medullary telangiectasia. Neurocrit Care. 2010;12(3):395-9.
[PubMed] [Google Scholar]
Ioos C, Estournet-Mathiaud B, Pinard JM, ChelioutHéraut F. Sleep disorders caused by brainstem tumor:
case report. J Child Neurol. 2001;16(10):767-70. [PubMed] [Google Scholar]
Matsuyama M, Nakazawa K, Katou M, Ota K, Masuko H, Iizuka T, Mori T, Hayashi H, Hayashihara K, Saito T,
Satoh M, Hizawa N. Central alveolar hypoventilation syndrome due to surgical resection for bulbar
hemangioblastoma. Intern Med. 2009;48(11):925-30. [PubMed] [Google Scholar]
Matschke J, Laas R. Sudden death due to central alveolar hypoventilation syndrome (Ondine’s curse)
in a 39-year-old woman with heterotopia of the inferior olive. Am J Forensic Med Pathol. 2007 Jun;28(2):141-4.
[PubMed] [Google Scholar]
Manning HL, Leiter JC. Respiratory control and respiratory sensation in a patient with a ganglioglioma
within the dorsocaudal brain stem. Am J Respir Crit Care Med. 2000;161(6):2100-6. [PubMed] [Google Scholar]
Marczak M, Pokorski M. Oxygen breathing and ventilation. J PhysiolPharmacol. 2003;55(1):127-34.
[Google Scholar]
Mirkin DB. Benzene and related aromatic hydrocarbons. In: Shannon MW, Borron SW, Burns MJ, editors. Haddad and Winchester’s clinical management of poisoning and drug overdose. 4th ed. WB Saunders; 2007. p. 1363-76.
Nakajima M, Katsura K, Hashimoto Y, Terasaki T, Uchino M. [A case of Ondine curse associated with a
medullary tumor]. RinshoShinkeigaku. 2000;40(8):811-5. Japanese. [PubMed] [Google Scholar]
Niazi AU, Mocon A, Varadi RG, Chan VW, Okrainec A. Ondine’s curse: anesthesia for laparoscopic
implantation of a diaphragm pacing stimulation system. Can J Anaesth. 2011;58(11):1034-8. [PubMed] [Google
Scholar]
Nowicka J, Kulikowska J, Korczyńska M, Celiński R, Chowaniec C. [Toxicological and medico-legal analyses
of sudden deaths resulting from butane inhalation]. Arch Med SadowejKryminol. 2011 Jan;61(1):43-6.
Polish. [PubMed] [Google Scholar]
Ochoa-Sepulveda JJ, Ochoa-Amor JJ. Ondine’scurse during pregnancy. J Neurol Neurosurg Psychiatry. 2005;76(2):294. [PubMed] [Google Scholar]
Pokorski M, Grieb P, Wideman J. Opiate system influences central respiratory chemosensors. Brain
Res. 1981;211(1):221-6. [PubMed] [Google Scholar]
Pokorski M, Morikawa T, Takaishi S, Masuda A, Ahn B, Honda Y. Paralysis of respiratory muscles and
hypoxic ventilatory chemoreflex. Biomed Biochim Acta. 1989;48(5-6):S573-7. [PubMed] [Google Scholar]
Rao GS, Ramesh VJ, Lalla RK. Ventilatory management and weaning in a patient with central hypoventilation
caused by a brainstem cavernoma. Acta Anaesthesiol Scand. 2005;49(8):1214-7. [PubMed] [Google Scholar]
Raslan AM. Percutaneous computed tomography-guided transdiscal low cervical cordotomy
for cancer pain as a method to avoid sleep apnea. StereotactFunctNeurosurg. 2005;83(4):159-
[PubMed] [Google Scholar]
Severinghaus JE. Ondine’s curse: failure of respiratory center automaticity while awake. Clin Res. 1962;10:122.
[Google Scholar]
Sarnoff SJ, Whittenberger JL, Affeldt JE. Hypoventilation syndrome in bulbar poliomyelitis. J Am Med
Assoc. 1951;147(1):30-4. [PubMed] [Google Scholar]
Schläfke ME, Pokorski M, See WR, Prill RK, Loeschcke HH. Chemosensitive neurons on the ventral medullary
surface. Bull Physiopathol Respir. 1975;11(2):277-84. [PubMed] [Google Scholar]
Siewiera J, Trnka J, Kübler A. do zabieguplanowe-go. AnestezjologiaIntensywna Terapia. 2013;45:48-53.
Polish. [Google Scholar]
Susło R, Trnka J, Siewiera J, Drobnik J. Ondine’s curse genetic and iatrogenic central hypoventilation as
diagnostic options in forensic medicine. In: Crusio WE, Dong H, Radeke HH, Rezaei N, Steinlein O, Xiao
J, editors. Advances in experimental medicine and biology. Springer; 2015. p. 65-73. [PubMed] [Google
Scholar]
Tanaka K, Kanamaru H, Morikawa A, Kawaguchi K. Central hypoventilation syndrome complicated
with lateral medullary infarction after endovascular treatment of the vertebral artery dissecting aneurysm:
a case report. NMC Case Rep J. 2016;3(4):133-6. [PubMed] [Google Scholar]
Tomczak E, Wiergowski M, Jankowski Z, Wilmanowska JA. [Dextromethorphan (DXM): new methods of
intoxications among teenagers--a case description].Arch Med SadowejKryminol. 2012;62(3):197-202. Polish.
[PubMed] [Google Scholar]
Trnka J, Gesicki M, Suslo R, Siuta J, Drobnik J, Pirogowicz I. Death as a result of violent asphyxia in autopsy
reports. Adv Exp Med Biol. 2013;788:413-6. [PubMed] [Google Scholar]
Udwadia ZF, Athale S, Misra VP, Wadia NH. Radiation necrosis causing failure of automatic ventilation during
sleep with central sleep apnea. Chest. 1987;92(3):567-9. [PubMed] [Google Scholar]
Valente S, De Rosa M, Culla G, Corbo GM, Ciappi G. An uncommon case of brainstem tumor
with selective involvement of the respiratory centers. Chest. 1993;103(6):1909-10. [PubMed] [Google Scholar]
Wiesel S, Fox GS. Anaesthesia for a patient with central alveolar hypoventilation syndrome (Ondine’s
Curse). Can J Anaesth. 1990;37(1):122-6. [PubMed] [Google Scholar]
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