Journal of Advanced Research in Medicine (E-ISSN: 2349-7181 & P-ISSN: 2394-7047) https://medical.advancedresearchpublications.com/ojs-3.1.2-4/index.php/MedicineJournal Advanced Research Publications en-US Journal of Advanced Research in Medicine (E-ISSN: 2349-7181 & P-ISSN: 2394-7047) 2394-7047 Breath After the Storm: Longitudinal Spirometry in COVID 19 Survivors- A prospective cohort study https://medical.advancedresearchpublications.com/ojs-3.1.2-4/index.php/MedicineJournal/article/view/5109 <p>Background: Persistent pulmonary dysfunction after COVID-19 pneumonia recovery remains a concern, with restrictive patterns commonly reported. This study assessed spirometric abnormalities in patients recovered from COVID-19 pneumonia and their associations with comorbidities, smoking, and disease severity.<br>Methods: A prospective cohort study enrolled 53 adults (&gt;18 years) discharged from COVID-19 wards after 6–12 weeks post-diagnosis. Inclusion required RT-PCR/RAT confirmation and bilateral infiltrates on chest imaging; exclusions included pre-existing respiratory/cardiac disease, obesity (BMI &gt;30 kg/m²), and pregnancy. Spirometry (Schiller Spirovit SP1) was performed at 6–12 weeks and repeated 3 months later. Data was analyzed using SPSS v25, with chi-square, t-tests, ANOVA, and logistic regression (p &lt; 0.05 is significant).<br>Results: The mean age of the subjects was 54.5 ± 12.3 years; 83% were male, 75% with comorbidities (mostly diabetes/hypertension), and 94% nonsmokers. Clinical severity: 49% of subjects had mild, 26% of subjects had moderate, and 25% of subjects had severe disease clinically and had a mean CTSS of 12.25 ± 5.96. Abnormal spirometry was found in 28.3% of subjects at the first follow-up (mostly restrictive, 20.8%) and 17% at the second follow-up (13.2% restrictive). Improvement noted in pulmonary function was statistically not insignificant (p = 0.441). Nonsmokers had better outcomes (p = 0.043 first and p = 0.001 second); severe cases showed more defects.<br>Conclusion: Restrictive ventilatory defect predominates post-COVID-19, with improvement over 3 months, influenced by smoking and severity. Larger studies including DLCO/plethysmography are needed.</p> <p><strong>DOI:</strong>10.24321/2349.7181.202507</p> <p><strong>How to cite this article:</strong><br>Poonam P, Anand S, Gupta A, Singh H, Garg S, Pradhan G S, Mishra R, Kumar N. Breath After the Storm: Longitudinal Spirometry in COVID 19 Survivors- A prospective cohort study. J Adv Res Med 2025; 12(3): 1-8.</p> Naresh Kumar Princy Poonam Shipra Anand Amitesh Gupta Harpreet Singh Sandeep Garg Gaurav Shankar Pradhan Rashmi Mishra Copyright (c) 2026 Naresh Kumar, Princy Poonam, Shipra Anand, Amitesh Gupta, Harpreet Singh, Sandeep Garg, Gaurav Shankar Pradhan, Rashmi Mishra https://creativecommons.org/licenses/by-nc/4.0 2026-04-21 2026-04-21 12 3 1 8