A New Perspective on Dengue Severity:  Elevated Serum Amyloid A and its Clinical  Significance in Hemorrhagic Fever

Sanjay  Goyal; Raminderpal  Singh Sibia; Preetpal  Singh; Chirag  Pasricha; Rupinder  Kaur; Rajwinder  Kaur; Pratima  Kumari; Ravinder  Singh; Sarita  Jangra; Thakur Gurjeet Singh Singh

Sanjay Goyal Government Medical College and Rajindra Hospital, Patiala, Punjab, India
Raminderpal Singh Sibia Government Medical College and Rajindra Hospital, Patiala, Punjab, India
Preetpal Singh Chitkara College of Pharmacy, Chitkara University, Punjab, India
Chirag Pasricha Chitkara College of Pharmacy, Chitkara University, Punjab, India
Rupinder Kaur Chitkara College of Pharmacy, Chitkara University, Punjab, India
Rajwinder Kaur Chitkara College of Pharmacy, Chitkara University, Punjab, India
Pratima Kumari Chitkara College of Pharmacy, Chitkara University, Punjab, India
Ravinder Singh Chitkara College of Pharmacy, Chitkara University, Punjab, India
Sarita Jangra Chitkara College of Pharmacy, Chitkara University, Punjab, India
Thakur Gurjeet Singh Singh Chitkara College of Pharmacy, Chitkara University, Punjab, India

Keywords: Serum Amyloid A, Dengue, Inflammation, Dengue Haemorrhagic Fever, Interleukins

Abstract

Background: Dengue fever, caused by four distinct RNA virus serotypes of the flaviviridae family, has become increasingly prevalent worldwide. Serum amyloid A has been implicated in various inflammatory diseases,
but its role in dengue is not thoroughly explored. Our study was aimed at evaluating the serum levels of SAA in individuals at various stages of dengue severity.
Methods: The cross-sectional study recruited 20 healthy participants aged 18-30 years from a tertiary care hospital in Punjab, i.e., DHF patients (nequal to 20), and 20 healthy participants from outside the hospital.
Biochemical assessments included measurements of TNF-alpha, IL-6, IL-13 and SAA using ELISA kits.

Conclusion: Elevated SAA levels were found to be strongly correlated with the severity of DHF, correlating with various haematological,iochemical, and inflammatory markers. SAA may serve as a valuable
diagnostic biomarker for evaluating the disease severity in dengue patients.

How to cite this article:
Goyal S, Sibia R S, Singh P, Pasricha C, Kaur R, Kaur R, Kumari P, Singh R, Jangra S, Singh T G. A New Perspective on Dengue Severity: Elevated Serum Amyloid a and Its Clinical Significance in Hemorrhagic Fever. J Commun
Dis. 2026;58(2):182-188.

DOI: https://doi.org/10.24321/0019.5138.202644

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