Unravelling the Role of the NLRP3 Inflammasome in Cardiovascular Diseases

Abstract

Cardiovascular disorders (CVDs) continue to be a major global health concern, requiring ongoing research into new treatment approaches. Emerging research has highlighted the intricate role of inflammation,
particularly mediated by the NLRP3 inflammasome, in the pathogenesis of CVDs. This review provides an overview of the NLRP3 inflammasome, its function, regulation, and implications in health and disease. In order to clarify the underlying mechanisms, we address its role in cardiovascular diseases such as atherosclerosis, myocardial infarction, heart failure, and hypertension. Additionally, we explore the therapeutic potential of targeting the NLRP3 inflammasome in CVDs, highlighting ongoing preclinical studies and clinical trials. Despite the promise of NLRP3 inhibition, several challenges exist, including achieving specificity, identifying biomarkers, and ensuring long-term safety. We propose future research directions, emphasising the need for personalised
approaches, combination therapies, and translational research to realise the full therapeutic potential of targeting the NLRP3 inflammasome in combating CVDs.

How to cite this article:
Yadav P. Unravelling the Role of the NLRP3
Inflammasome in Cardiovascular Diseases. Int J
Preven Curat Comm Med. 2024;10(3&4):18-23.

DOI: https://doi.org/10.24321/2454.325X.202407