Urinary Lactate as a Predictor of Early Onset Sepsis in Neonates
Objectives: Diagnosing Early-Onset Sepsis (EOS) requires a sensitive, specific, and easily available marker. This study was conducted for the estimation of the cut-off level of urinary and plasma lactate for the diagnosis of EOS.
Study Design: Hundred neonates at risk of early onset sepsis were included. Sepsis screen, blood culture, and plasma lactate within 2 hours and urinary lactate in the first urine sample were done. CRP, plasma and urinary lactate were repeated at 24 Â± 2 hours. Receiver-operating characteristic curve was drawn to find the optimal cut-off point of urinary and plasma lactate levels.
Results: Median urinary lactate in the sepsis group were 0.6 mMol/L and 0.40 mMol/L and in the non-sepsis group, they were 0.41 mMol/L and 0.38 mMol/L in the 1st passed sample and at 24 hours respectively. Both urinary and plasma lactate were not able to diagnose early onset sepsis. However, urinary lactate proved to be a useful marker for diagnosing sepsis with shock and mortality.
Conclusion: Our study concludes that although urinary and plasma lactate do not predict EOS, urinary lactate can predict shock and mortality in babies with EOS at 24 hours of life.
How to cite this article:
Bhat RR, Batra P, Harit D, Banerjee B, Kotru M, Sharma T, Chillar N. Urinary Lactate as a Predictor of Early Onset Sepsis in Neonates. Postgrad J Pediatr Adol Med. 2022;1(2):10-15.
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