Journal of Advanced Research in Medicine (E-ISSN: 2349-7181 & P-ISSN: 2394-7047)

A Case Report of Koro and Dhat Syndrome

2026-01-31T09:32:41+00:00

Culture-bound syndrome is a term used to describe patterned behaviors of distress or illness whose phenomenology appeared distinct from psychiatric categories and were considered unique to particular cultural settings. We need to understand the origins of cognitions related to these syndromes. We report a case of a 19-year-old male presenting with two culture-bound syndromes: koro and Dhat.

“Anticancer properties of Natural products” – A Review

2026-02-02T06:44:04+00:00

The challenge of cancer remains one of the significant challenges for the health of the world; millions suffer every year. Despite the significant improvements in conventional approaches like chemotherapy and radiation and their continued inclusion in modern treatment protocols, the potential for toxic side effects and treatment resistance has led to a growing interest in alternative therapies. Natural products extracted from plants, marine organisms, and microorganisms constitute a major portion of traditional medicines. Researchers are now discovering these compounds for their anticancer activity. Researchers assert curcumin, resveratrol, and EGCG, among other important compounds, can prevent the proliferation of cancer cells, induce apoptosis, and suppress metastasis by activating a variety of pathways inside the cells. We discuss here the mechanisms through which these natural compounds cause apoptosis, control the cycle of a cell, possess anti-metastatic properties, and regulate redox. A major area of controversy remains the ability of natural products to complement traditional treatments—that is, their ability to enhance treatment results with synergistic effects. The review also considers the challenges posed by the low solubility and poor bioavailability of compounds like curcumin and explores strategies to modify their structure for improved efficacy. Therefore, this review has advocated for additional research on natural products as complementary or alternative cancer treatments, with a focus on clinical applications and the identification of molecular mechanisms that could enhance therapeutic strategies. The results showed the potential of natural compounds in providing safer and more effective treatment options for cancer and encouraged further research on the integration of such natural compounds into mainstream oncology practices.

A Case Report on Neurobrucellosis: A forgotten Cause of Meningoencephalitis

2026-02-02T06:08:24+00:00

Abstract

Human brucellosis caused by Brucella melitensis is the most prevalent zoonotic infection globally. This report highlights a case of neurobrucellosis in a male patient from rural India, underscoring the importance of timely clinical suspicion followed by microbiological confirmation. A 64-year-old farmer from Himachal Pradesh, India, presented to us with a short history of fever, moderate diffuse headache, and myalgia. He subsequently developed sudden-onset left hemiparesis, disorientation, bilateral sensorineural hearing loss, and neck rigidity. Laboratory investigations revealed abnormal blood counts, and cerebrospinal fluid analysis showed increased lymphocytes and protein content. Serological tests confirmed the diagnosis of neurobrucellosis. Prompt initiation of antibiotic therapy resulted in significant clinical improvement. This case highlights neurobrucellosis as a rare but a significant manifestation. It is important to consider it as a differential in a patient of atypical meningoencephalitis. A very specific history of contact with livestock or unpasteurised dairy is also imperative. The patient’s swift response to targeted antibiotic therapy underscores the value of timely diagnosis and effective management in improving outcomes.