Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138)
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases
<p>The <em><strong>Journal of Communicable Diseases</strong> has been indexed in <strong>SCOPUS</strong>.</em></p> <p><a href="https://www.scopus.com/sourceid/22422">https://www.scopus.com/sources.uri</a></p> <p><strong>UGC Approved Journal</strong></p>en-USJournal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138)0019-5138A Descriptive Study to Assess the Prevalence of Fungal Infections among Patients with Diabetes Mellitus and Hypertension and Their Risk Factors in a Community of Delhi
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4086
<p>Introduction: Diabetic patients are at higher risk of various health<br>problemsincluding fungal infections. Fungal infections are taken less<br>seriously but if not identified and treated promptly, may lead to resistant<br>infections, further complications and impaired quality of life.<br>Objectives: To assess the prevalence of fungal infections among diabetic<br>patients and risk factors of hypertension and diabetes mellitus<br>Methods: A descriptive survey research design was used. The study was<br>conducted among people residing in a selected area of Delhi. A purposive<br>sampling technique was used to collect 313 samples. A structured<br>interview schedule was used to collect the data,. Permission was<br>obtained from local authorities. An informed consent was obtained prior<br>to study participation. Data was analysed using descriptive statistics.<br>Results: 28.1% of people are suffering from diabetes, and out of those<br>only 88.6 % of people are taking medication. A total of 90.9% of diabetic<br>participants had a fungal infection. Out of that, 18.7 % had fungal<br>infections more than once a month,33.7 % were not taking any treatment<br>for fungal infection, 31.2% were taking home and natural remedies,<br>22.5 % were using topical antifungal creams (some containing steroids)<br>or suppositories and 12.5% were taking oral anti-fungal medication.<br>Conclusion: Diabetic patients have increased susceptibility to various<br>infections, including fungal infections emphasising the need for<br>comprehensive research and effective management strategies. This<br>study highlights the need for effective preventive strategieswhich could<br>significantly reduce healthcare costs and improve patients’ quality of life.</p> <p>How to cite this article:<br>John N, Rani S, Bhattarcharya S, Negi A. A<br>Descriptive Study to Assess the Prevalence of<br>Fungal Infections among Patients with Diabetes<br>Mellitus and Hypertension and Their Risk<br>Factors in a Community of Delhi. J Commun<br>Dis. 2025;57(1):1-8.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202501</p>Seema RaniNeha JohnSuchhanda BhattarcharyaArushi Negi
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2025-04-032025-04-0357118Aedes-borne disease awareness in Thiruvarur District of Tamil Nadu, India
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/3064
<p>Background: In India, vector-borne diseases account for the high burden<br>of all infectious diseases (WHO, 2020). Among these, Dengue Fever<br>(DF) is the most common viral disease transmitted by Aedes spp. such<br>as Aedes aegypti and Aedes albopictus.<br>Aim of the study: This study aimed to identify and assess the Knowledge,<br>Attitude, and Practices (KAP) of Dengue fever among the University /<br>College students in Thiruvarur district, Tamil Nadu, India.<br>Methods: A cross-sectional study was conducted at 13 University/<br>Colleges from Thiruvarur district. The targeted study group was above<br>the age group of 17 years from the rural and urban settings of Thiruvarur<br>district. The study instrument contains a questionnaire on knowledge,<br>attitude, and practices regarding Dengue fever in university/ college<br>students.<br>Results: In the present study, the prime source from which the students<br>received information on Dengue Knowledge was from TV (68.6%). There<br>was significant association between knowledge level and educational<br>level (X2<br>= 3.964, df=1, p < 0.05), between knowledge, attitude and<br>practices with the Institutional type (X2</p> <p>= 4.35, 6.315, 6.662 df=1, p <</p> <p>0.05) and between practices and gender (X2</p> <p>= 3.866 df=1, p < 0.05). There<br>was positive moderate correlation between Knowledge and Attitude<br>(r=0.441), between Attitude and Practice (r=0.606), and there was a<br>positive weak correlation between Knowledge and Practice (r=0.374).<br>Conclusion: Despite having sufficient knowledge regarding dengue<br>fever, students is still lacking in the knowledge of vector transmission<br>and breeding grounds. This suggests that the public health authorities<br>should implement future intervention strategies and conduct health<br>education programs.</p> <p>How to cite this article:<br>Liston F D O R, Hatibaruah A, Jeevith S B, Farhat<br>S K, Anbalagan R, Philip N E, Krishnan J, Binduja<br>S. Aedes-borne disease awareness in Thiruvarur<br>District of Tamil Nadu, India. J Commun Dis.<br>2025;57(1):9-19.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202502</p>Liston FDO RAnanya HatibaruahSathya Jeevitha BFarhat S KRajalakshmi AnbalaganNeena Elezebeth PhilipJayalakshmi KrishnanBinduja S
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2025-04-032025-04-03571919An Integrated Multi-Agent Frameworks for COVID-19 Detection Using Machine Learning and Deep Learning Techniques
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4328
<p>The SARSCoV-2 virus causes the infectious illness known as coronavirus<br>disease (COVID-19). In recent decades, COVID-19 has become the most<br>infectious disease. Millions of individuals worldwide suffer from this<br>disease. Because of the restricted availability and sensitivity of testing<br>kits, doctors and researchers have turned to computer tomography<br>(CT) scans to screen for COVID-19. Recent technological developments<br>and the widespread use of machine learning (ML) and deep learning<br>(DL) techniques have shown high potential in terms of more accurate<br>COVID-19 detection. Therefore, in this paper, we have developed two<br>multi-agent frameworks for COVID-19 detection using the ML and DL<br>algorithms. In the first framework, several ML algorithms, namely, KNN,</p> <p>LR, and SVM, are employed. Further, ensemble learning and hypertun-<br>ing of the ML algorithms is done using the grid search method. Next,</p> <p>reinforcement learning method Q learning agent is used to update the<br>multi-agent framework. On the other hand, the second multi-agent<br>framework is developed with the help of lightweight ResNet and<br>reinforcement PPO algorithms. Further, in both frameworks, feature<br>selection is done using the LRP-ET method to determine the appropriate<br>features from the dataset. The experimental results are performed on<br>the Google Colab software for the standard dataset. The dataset is split<br>into an 80:20 ratio to train and test the frameworks. The evaluation<br>of both frameworks is done using the various parameters, namely,<br>accuracy, precision, recall, and F-score. The results show that both<br>frameworks outperform the existing models. Finally, the comparison<br>of both frameworks shows that the second framework, which is based<br>on deep learning, performs superiorly over the first framework, which<br>is based on ML, due to efficiently handling complex data.</p> <p>How to cite this article:<br>Walia R K, Kaur H. An Integrated Multi-Agent<br>Frameworks for COVID-19 Detection Using<br>Machine Learning and Deep Learning Techniques.<br>J Commun Dis. 2025;57(1):20-32.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202503</p>Rupinder Kaur Walia Harjot Kaur
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2025-04-032025-04-035712032Beyond the Epidemic Diseases Act, 1897: Rethinking India’s Public Health Laws for Pandemic Preparedness – Lessons from Singapore
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4447
<p>The Epidemic Diseases Act (EDA), 1897, was enacted in the late 19th<br>century in the wake of the third plague pandemic in India and was<br>a significant step in colonial public health legislation. However, more<br>than a century later, the COVID-19 pandemic laid out how outdated<br>this law is for addressing current public health challenges. This research<br>article examines the historical antecedents and shortcomings of the<br>EDA, 1897, and compares India’s public health response with that of<br>a country like Singapore which has a comprehensive and exhaustive<br>approach to tackling public health through a legal mandate under<br>the Infectious Diseases Act, 1976. The article also examines the<br>Public Health (Prevention, Control and Management of Epidemics,<br>Bio-terrorism and Disasters) Bill, 2017 which tried to replace the EDA</p> <p>but never came into being due to its centralisation of power and non-<br>consultation with civil society. The study compares the effectiveness</p> <p>of lockdown measures taken against the COVID-19 pandemic in both<br>countries through a comparative analysis of COVID-19 data and stresses<br>that legal frameworks, governance, and public accountability are<br>critical in the management of epidemics. The study further provides<br>practical suggestions to reinforce India’s public health system, focusing<br>on revamping legal provisions, strengthening healthcare infrastructure<br>capacities, upgrading Centre-State coordination, and ensuring India<br>has access to devolved and contextual measures in future crises.<br>Adaptation of world-class practices including that of Singapore can<br>help India build a future-ready proactive public health system that can<br>ensure protection for its population against future health challenges.</p> <p>How to cite this article:<br>Anand A, Ranjan P, Kumar R. Beyond the Epidemic<br>Diseases Act, 1897: Rethinking India’s Public<br>Health Laws for Pandemic Preparedness – Lessons<br>from Singapore. J Commun Dis. 2025;57(1):33-43.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202504</p> Ankit AnandPriya RanjanRajneesh Kumar
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2025-04-032025-04-035713343Biofilm Feast: Stringent Response-Induced Changes in MRSA and MSSA Isolates, Examining icaA/ icaD Gene Expression
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/3413
<p>Introduction: The stringent response is a bacterial adaptation mechanism<br>triggered by stress conditions, including nutrient limitation. This<br>response helps bacteria survive under harsh conditions, such as those<br>encountered during infection. A key feature of the stringent response<br>is the synthesis of the alarmone (p)ppGpp, which influences various<br>bacterial phenotypes. In several bacterial species, stringent response<br>activation significantly affects biofilm formation and maintenance.<br>Methods: Clinical specimens were collected from multiple hospitals in<br>Baghdad, Iraq. Staphylococcus aureus was identified using conventional<br>biochemical tests. The PCR technique was applied to detect mecA,<br>icaA, and icaD genes, while the Vitek 2 compact system confirmed<br>Methicillin sensitivity in mecA-negative isolates. Biofilm intensity of all<br>S. aureus isolates was assessed under normal and starved conditions.<br>Additionally, the gene expression levels of icaA and icaD were measured<br>in five MRSA and five MSSA strains under both conditions.<br>Results: The mecA, icaA, and icaD genes were detected in 94%, 96.3%,<br>and 100% of S. aureus isolates, respectively. Biofilm production<br>analysis showed that 24% of isolates were strong producers, 49%<br>were moderate producers, and 9% were weak producers. Statistical<br>analysis indicated that biofilm intensity significantly decreased under<br>nutrient limitation (p < 0.0001) compared to normal conditions across<br>all isolates. Furthermore, icaA and icaD genes were upregulated under<br>stringent response conditions, regardless of Methicillin resistance status.<br>Conclusion: The stringent response influences S. aureus biofilm<br>formation, with biofilm intensity decreasing under nutrient-limited<br>conditions. However, the upregulation of icaA and icaD genes suggests<br>a regulatory role of the stringent response in biofilm-related gene<br>expression. These findings highlight the potential impact of stress<br>adaptation mechanisms on bacterial persistence and pathogenicity.</p> <p><strong>How to cite this article:</strong><br>Mussa A A, Mathkhury H J F A. Biofilm Feast:<br>Stringent Response-Induced Changes in MRSA<br>and MSSA Isolates, Examining icaA/ icaD Gene<br>Expression. J Commun Dis. 2025;57(1):44-54.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202505</p>Ali A MussaHarith Jabbar Fahad Al Mathkhury
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2025-04-032025-04-035714454Community Healthcare Providers’ Perspective on Malaria Control in Difficult Terrains (DAMaN) in Odisha, India
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4187
<p>Introduction: Malaria remains a major public health challenge, especially<br>in remote areas with limited healthcare. The WHO-endorsed Mass<br>Testing and Treatment (MTaT) strategy targets high-prevalence regions<br>by screening and treating entire populations. In India, Odisha’s DAMaN<br>programme integrates MTaT with health services to combat malaria in<br>tribal communities. This study explores community healthcare providers’<br>perspectives on MTaT under DAMaN.<br>Methods: The study involved 53 community health workers (CHWs)<br>from five districts, including Accredited Social Health Activists, Auxiliary<br>Nurse Midwives, and Community Health Officers. Data were analysed<br>using thematic analysis.<br>Results: Three themes emerged: 1) Equity in malaria service delivery</p> <p>among remote, hilly areas and vulnerable tribal populations, 2) Non-<br>malaria service benefits from mass testing and treatment of malaria</p> <p>in remote areas, and 3) Challenges and suggestions for addressing<br>implementation gaps. The DAMaN programme has significantly reduced<br>malaria prevalence and improved healthcare access in remote villages<br>by integrating malaria control with broader health services and fostering<br>community engagement. It has strengthened trust in public healthcare<br>systems and improved health outcomes. However, challenges like<br>infrastructure, workforce limitations, socio-cultural resistance, and<br>resource availability need to be addressed to sustain its impact.<br>Conclusion: Suggestions for improving scheduling flexibility, increasing<br>camp frequency, incentivising volunteers, and fostering inter-departmental<br>collaboration could further strengthen DAMaN’s effectiveness and<br>sustainability.</p> <p>How to cite this article:<br>Pradhan M M, Sahoo K C, Patra A, Nanda B, Bag,<br>Dey N, Sahu K, Pati S. Community Healthcare<br>Providers’ Perspective on Malaria Control in<br>Difficult Terrains (DAMaN) in Odisha, India. J<br>Commun Dis. 2025;57(1):55-64.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202506</p>Madan Mohan PradhanKrushna Chandra SahooAnnapurna PatraNirupama DasBaladeba NandaKumuda Chandra SahuSantosh BaghSanghamitra Pati
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2025-04-032025-04-035715564Comparative Analysis of Hepatitis E and A in Children: Clinical Manifestations and Epidemiological Patterns in Kyrgyzstan
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4421
<p>Introduction: Viral hepatitis E (HEV) poses a significant global health<br>challenge with limited research on its impact on children. This<br>retrospective study aimed to identify the clinical and laboratory features<br>of HEV in children and compare them with those of hepatitis A virus<br>(HAV) infections in the Kyrgyz Republic.<br>Methods: Clinical and laboratory data from children diagnosed with HEV<br>(n=31) and HAV (n=42) at the three regional hospitals were analyzed.<br>Results: HEV cases were predominantly male (74.1%), aged 1-5 years<br>(42%), and from rural areas (77.4%), while HAV showed no significant<br>gender or urban-rural disparity. HEV patients experienced a more severe<br>clinical course, with 13% classified as severe compared with 4.7% of HAV<br>cases. HEV infection resulted in prolonged symptom duration during<br>the pre-jaundice and jaundice phases, with longer periods of fever,<br>weakness, decreased appetite, vomiting, and abdominal pain (P<0.05).<br>Blood biochemistry revealed higher total and indirect bilirubin levels<br>in HEV patients (P<0.05) and lower total protein levels in severe HEV<br>cases (P<0.05). The mean hospitalization duration was longer for HEV<br>(17.2±1.3 days) than HAV (12.7±1.2 days; P<0.05).<br>Conclusion: The study found the clinical manifestations of children<br>with HEV were severe and longer in duration as compared to children<br>with HAV. These findings highlight the importance of timely diagnosis<br>of HEV and preventive measures, particularly in rural areas.</p> <p>How to cite this article:<br>Tashov K, Anarbaeva J, Murzakulova A,<br>Abdyraeva B, Tashpolotova A, Abdikerimov M,<br>Djumagulova A, Mambetova M, Suranbaeva<br>G, Vityala Y. Comparative Analysis of Hepatitis<br>E and A in Children: Clinical Manifestations<br>and Epidemiological Patterns in Kyrgyzstan. J<br>Commun Dis. 2025;57(1):65-72.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202507</p>Kursanali TashovJumagul AnarbaevaAltynai MurzakulovaBaktygul AbdyraevaAnarkan TashpolotovaMamazia AbdikerimovAnara DjumagulovaMadina MambetovaGulmira SuranbaevaYethindra Vityala
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2025-04-032025-04-035716572Comparative Evaluation of Rapid Antigen Detection Assay and RT-PCR for SARS-CoV-2 Diagnosis in a Tertiary Care Setting
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4028
Pinki Kumari Jiwesh Kumar ThakurAditya Kumar JhaSatyendra Prasad Yadav
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2025-04-032025-04-035717378Diversity and Distribution of the Aedes Vectors in the Coastal Sites of Puducherry, Southern India
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4077
<p>Introduction: Dengue poses a significant public health challenge<br>in Pondicherry. Understanding the distribution of Aedes mosquito<br>populations is critical for devising and implementing effective vector<br>control strategies.<br>Methods: This study aimed to measure the abundance of dengue<br>vectors through entomological surveillance methods and to evaluate<br>the potential for dengue virus transmission within the coastal regions<br>of Pondicherry. An entomological survey was carried out across nine<br>randomly selected localities within Puducherry, in and around the<br>premises, during 2019–2020, covering 180 households monthly.<br>Results: The analysis for the Adult Premise Index, per man hour density,<br>and correlation was calculated using the SPSS Version 16.0 for assessing<br>significant findings. The study found that Aedes mosquitoes infested<br>24.9% of the 537 positive houses. The adult density of Aedes mosquitoes<br>was 16.6 per 10 person-hours and the average number of mosquitoes<br>per house was 0.27 per 10 man-hours. The per-person-hour density<br>of Aedes mosquitoes varied from 8.0 to 23.7 and was more abundant<br>during monsoon months. Similarly, the adult premise index of Aedes<br>mosquitoes varied from 8.9 to 36.7 and did not differ significantly<br>in various months. Ae. aegypti was the predominant dengue vector<br>followed by Ae. albopictus, which was most prevalent in June and less<br>prevalent in February.<br>Conclusion: The current study provides valuable baseline data on the<br>abundance and distribution of dengue vectors in the coastal areas of<br>Pondicherry. Continued entomological surveillance is necessary to<br>monitor the effective of control measures and detect changes in vector<br>abundance and distribution over time.</p> <p>Velan I, Prasad P, Baskar V, Venkat V, Anil A,<br>Ragupathi L. Diversity and Distribution of the<br>Aedes Vectors in the Coastal Sites of Puducherry,<br>Southern India. J Commun Dis. 2025;57(1):79-84.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202509</p> Iyyappan VelanPooja PrasadVetrivel BaskarVinoth VenkatAthira AnilLokesh Ragupathi
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2025-04-032025-04-035717984Drug Susceptibility Testing of Mycobacterium Tuberculosis for Isoniazid and Rifampicin by Absolute Concentration and MTT method – A Comparative Study
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4170
<p>Introduction: Tuberculosis has been a main cause of mortality and<br>morbidity globally. In spite of having anti-tuberculous drugs, elimination<br>of tuberculosis is difficult because of the drug resistance. In order to<br>achieve vital therapy selection and prevention of resistance, expeditious<br>detection along with drug susceptibility techniques are essential needs<br>of the hour.<br>Aim: To evaluate the MTT assay and the absolute concentration method<br>for determining Mycobacterium tuberculosis susceptibility to rifampicin<br>and isoniazid<br>Methods: 71 isolates of Mycobacterium tuberculosis were tested for<br>susceptibility to the first-line medications isoniazid and rifampicin using<br>the MTT assay and the absolute concentration method after sputum<br>samples that tested positive for acid-fast bacilli were gathered.<br>Results: Of the 71 isolates, 14% (10) were resistant to isoniazid and<br>9% (6) were resistant to rifampicin by absolute concentration method.<br>Isoniazid resistance was seen in 13% (9) and 10% (7) were resistant to<br>rifampicin by MTT assay. Isoniazid mono resistance was observed in<br>5 isolates and 1 isolate to rifampicin alone by absolute concentration<br>method. Two isolates that were mono-resistant to rifampicin and four<br>isolates that were mono-resistant to isoniazid were acquired using the<br>MTT assay. Both the absolute concentration approach and the MTT<br>experiment revealed that 7% (5) of the isolates were multidrug resistant.<br>Conclusion: Increasing numbers of resistant and multidrug-resistant<br>tuberculosis (MDR-TB) strains have led to a daunting need for rapid,<br>reliable, and accurate drug susceptibility testing. Hence, we concluded<br>that the absolute concentration method is better than the MTT assay in<br>terms of simplicity of performance though the results may be delayed.</p> <p>How to cite this article:<br>Santharam P, Govindarajan V. Drug Susceptibility<br>Testing of Mycobacterium Tuberculosis<br>for Isoniazid and Rifampicin by Absolute<br>Concentration and MTT method – A Comparative<br>Study. J Commun Dis. 2025;57(1):85-90.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202510</p> Priya SantharamVimal Govindarajan
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2025-04-032025-04-035718590Efficiently Predicting HIV-1 Protease Cleavage Sites by Using Deep CNN-Assisted Hybridised Approach
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4088
<p>Acquired Immuno Deficiency Syndrome (AIDS) is considered a vital<br>danger over the feasible development and on account of its pestilence<br>effect and nonattendance of reparable medicines. HIV-1 AIDS can be<br>constrained by utilising protease inhibitors. Different procedures for<br>predicting sites are utilised to comprehend the highlighted sites of those<br>proteases. Arrangement-based sites like physiochemical elements and<br>construction-based sites are separated from HIV-1 proteases. In this<br>article, a procedure for choosing those sites using a deep CNN-assisted<br>hybridised approach will be used for effectively predicting cleavage sites.<br>The proposed methodology was evaluated based on various Type-1 and<br>Type-2 parameters. The proposed approach gives superior results on<br>Type-1 and Type-2 parameters. Data746_setset provides an accuracy of<br>0.924, data 1625_set provides an accuracy of 0.946, Data_schilling_set<br>provides an accuracy of 0.9389, Data_impens_set provides an accuracy</p> <p>of 0.911 and average dataset provides an accuracy of 0.921 for Type-<br>1 parameters. Data746_setset provides an accuracy of 0.84664, data</p> <p>1625_set provides an accuracy of 0.34179, data_schilling_set provides<br>an accuracy of 0.69529 and data_impens_set provides an accuracy of<br>0.59511 for Type-2 parameters.</p> <p>Saini S, Kaur G. Efficiently Predicting HIV-1</p> <p>Protease Cleavage Sites by Using Deep CNN-<br>Assisted Hybridised Approach. J Commun Dis.</p> <p>2025;57(1):91-95.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202511</p>Navneet Kaur BawaSatish SainiGagandeep Kaur
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2025-04-032025-04-035719195Evaluating the Clinical Utility of C-Reactive Protein , Procalcitonin, and Presepsin as Biomarkers in Sepsis Diagnosis and Prognosis of the Infections
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4093
<p>Introduction: Sepsis, caused by an uncontrolled immune response,<br>leads to high mortality and poses challenges for early diagnosis due<br>to symptom variability. Standard blood cultures often fail, highlighting<br>the need for reliable biomarkers. This study assessed C-reactive protein<br>(CRP), procalcitonin (PCT), and presepsin to improve early detection<br>and minimise unnecessary antibiotic use.<br>Materials and Method: This retrospective study involved 100 patients<br>with sepsis in the Medical ICU, adhering to the American College of<br>Chest Physicians’ guidelines. Blood samples were analysed for CRP,<br>PCT, and presepsin using appropriate assays. Data were processed in<br>MS Excel and analysed with SPSS (version 25).<br>Results: Among the 100 patients (median age 42 years), 56% had sepsis,<br>18% severe sepsis, and 26% septic shock. Common comorbidities<br>included diabetes (21.4%) and hypertension (19.6%). Significant<br>biomarker differences were noted: PCT levels were highest in septic<br>shock (6.5 ng/mL), followed by severe sepsis (3.2 ng/mL) and sepsis (1.8<br>ng/mL) (p < 0.001). CRP and presepsin levels also showed significant<br>variations. Sensitivity was 85% for CRP, 90% for PCT, and 92% for<br>presepsin, and specificity values were 70%, 75%, and 80%, respectively.<br>Conclusion: This study emphasises the varying efficacy of CRP, PCT, and<br>presepsin in diagnosing sepsis and its severity. The notable differences<br>in biomarker levels across sepsis stages highlight the importance of early<br>identification and intervention. Future research should investigate the<br>integration of these biomarkers with clinical scoring systems to improve<br>sepsis management and outcomes in infected persons.</p> <p>Singhal A K, Bansal S K, Harith A K, Saha T K.<br>Evaluating the Clinical Utility of C-Reactive<br>Protein , Procalcitonin, and Presepsin<br>as Biomarkers in Sepsis Diagnosis and<br>Prognosis of the Infections. J Commun Dis.<br>2025;57(1):96-100.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202512</p>A K SinghalSK BansalA K HarithTK Saha
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2025-04-032025-04-0357196100Evaluation of Treatment Outcomes in Shorter and Longer Regimen Treatment in Multi-Drug Resistant Tuberculosis (MDR-TB) Patients in District Etawah: A Longitudinal Study
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4232
<p><strong>Background:</strong> Multi-drug resistance tuberculosis is a worldwide problem with a notoriously difficult and challenging treatment. There are two treatment regimens for MDR-TB treatment.</p> <p><strong>Objectives:</strong> To compare the predisposing risk factors and treatment outcomes in two different drug regimens for the treatment of MDR-TB.</p> <p><strong>Material and methods:</strong> A field based longitudinal study was carried out among 50 microbiologically confirmed MDR-TB patients of age 18 years and above, enrolled from January 2020 to December 2020 of district Etawah. Variables recorded were socio-demographics, clinical profile and treatment outcomes.</p> <p><strong>Result: </strong>Mean age of the participants was 30.70±12.52 years. Most of the participants were female (58%) and belonged to Class II and III of Modified BG Prasad Classification. Most of the participants (62%) had BMI of <18.5Kg/m<sup>2</sup>. About 93% of the study participants in the shorter regimen completed the treatment and were cured. The participants with no prior history of tuberculosis had better treatment outcome (p=<0.001). <sup> </sup></p> <p><strong>Conclusion: </strong>The present study concludes that successful treatment outcome is more in shorter treatment regimen compared to longer treatment regimen.</p> <p><strong>Keywords:</strong> MDR-TB, shorter regimen, longer regimen, treatment outcomes, NTEP, India</p>Rahul VermaDhiraj Kumar SrivastavaSandip KumarMohit MishraAlankrita AcharyaAnkur Baidya
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2025-04-032025-04-03571101108Exploring Dentists’ Awareness and Approaches to Mucormycosis: A Post-COVID Orofacial Complication in the Context of Communicable Diseases
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4441
<p>Iintroduction: COVID-19 has increased opportunistic infections like<br>mucormycosis, especially in immunocompromised individuals. Dentists<br>play a key role in early detection and management of post-COVID<br>oral complications, yet their awareness of mucormycosis remains<br>underexplored.<br>Objective: This study assesses dentists’ knowledge, attitudes, and<br>practices regarding mucormycosis as a post-COVID orofacial complication.<br>Methods: A cross-sectional study analyzed dentists’ demographics,<br>awareness, and clinical practices on post-COVID mucormycosis. Data<br>were statistically analyzed using SPSS 21.0.</p> <p>Results: Among participants, 81.6% had a fair understanding of post-<br>COVID fungal infections, and 99.2% correctly identified mucormycosis.</p> <p>However, only 77.6% knew its diagnostic criteria. While 87% recognized<br>mucormycosis as a complication, 72.8% identified rhino-orbital-cerebral<br>mucormycosis as the most common type. Additionally, 73% were<br>aware of treatment protocols, but only 17.8% had screened patients<br>in the past year.<br>Conclusion: Although dentists show strong awareness, gaps exist in<br>clinical preparedness and diagnostic accuracy. Targeted training can<br>enhance early detection, intervention, and multidisciplinary collaboration<br>for better patient outcomes.</p> <p>How to cite this article:<br>Kumar M, Murugaiyan U, Jha A, Singh A,<br>Kumar B S, Venkatesh M, Arjun B, Kumari N.<br>Exploring Dentists’ Awareness and Approaches<br>to Mucormycosis: A Post-COVID Orofacial<br>Complication in the Context of Communicable<br>Diseases. J Commun Dis. 2025;57(1):109-114.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202514</p>Mukesh KumarUma MurugaiyanAbhinav JhaAbhishek SinghB SendilKumar M VenkateshB ArjunNamrata Kumari
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2025-04-032025-04-03571109114Haematological and Biochemical Parameters in COVID-19 Patients Attending a Tertiary Care Hospital: A Retrospective Study
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4319
<p>Introduction: The SARS-CoV-2 RNA virus, which causes COVID-19<br>disease, rapidly spread to the entire world. COVID-19 mainly involves the<br>respiratory tract, now found to be linked with systemic diseases due to<br>multiple organ involvement. Limited data are available regarding the effect<br>of COVID-19 on various haematological and biochemical parameters.<br>Materials and Methods: A retrospective cross-sectional study was carried<br>out on 400 cases from March 2021 to August 2021. Two hundred<br>COVID-19 RT-PCR confirmed cases formed the study group and 200<br>subjects who tested negative were included in the controls to study<br>various haematological and biochemical parameters.<br>Results: Thrombocytopenia was significantly noticed in cases as compared<br>to controls (65.3% and 34.7%, respectively), with cases 2.45 times more<br>likely to be thrombocytopenic (p < 0.01). Leucopenia was 1.79 times<br>higher in cases (62.8%) in comparison to controls (37.2%). Moreover,<br>positive cases were 1.35 times more anaemic than control. The mean<br>indices for serum bilirubin (p = 0.020), serum creatinine (p < 0.001),<br>alanine transaminase (p = 0.081), blood urea (p < 0.001), procalcitonin<br>(p < 0.001) and c-reactive protein (p < 0.001) were significantly raised<br>in cases in comparison to controls.<br>Conclusion: Thrombocytopenia, leucopenia along with raised serum<br>bilirubin, creatinine, ALT, AST, CRP and procalcitonin may be beneficial<br>in the diagnosis of COVID-19. Meticulous assessment and correlation of<br>haematological and biochemical parameters at the time of admission and<br>simultaneously during the disease course will be helpful to physicians<br>in formulating individualised treatment along with decision-making<br>regarding requiring intensive care to those in need.</p> <p>How to cite this article:<br>Omhare A, Singh S, Yadav S K, Yadav K, Chaudhary<br>S, Mishra K L. Haematological and Biochemical<br>Parameters in COVID-19 Patients Attending a<br>Tertiary Care Hospital: A Retrospective Study. J<br>Commun Dis. 2025;57(1):115-120.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202515</p> Anita OmhareShilpi SinghSuresh Kumar Yadav Kiran YadavSachin ChaudharyKanhaiya Lal Mishra
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2025-04-032025-04-03571115120Knowledge, Attitude, and Practices Regarding Dengue Infection: A Community-Based Study in Rural Cox’s Bazar
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4186
<p>Introduction: Dengue, an emerging infectious disease spread by<br>mosquitoes, poses a significant public health challenge, especially in<br>tropical and subtropical areas like Bangladesh.<br>Methods: We conducted a community-based cross-sectional study to<br>assess the levels of knowledge, attitude, and practice (KAP) towards<br>dengue infection among 484 adult rural people in the purposively<br>selected Shikderpara and Muhuripara villages, Cox’s Bazar. Face-to-face<br>interviews were performed at the convenience of study participants<br>using a pretested, semi-structured questionnaire.<br>Results: The mean age of participants was 33.3 ± 13.5 years, with<br>the majority (53.9%) extending between 18 and 34 years. About<br>two-thirds (72.9%) of the residents were literate. Most participants<br>demonstrated average knowledge (84.3%), a positive attitude towards<br>dengue infection (63.0%), and average prevention practices (57.2%).<br>There was a significant association between participants’ practice levels<br>and their knowledge and attitude (p < 0.05), along with a statistically<br>significant correlation between their knowledge and dengue prevention<br>practices (p < 0.05).<br>Conclusion: Although the attitude toward dengue infection was positive,<br>knowledge and practices were average. This can be improved by<br>promoting community participation and implementing comprehensive<br>public health measures at all levels.</p> <p>How to cite this article:<br>Pure E, Husna A L A, Rokony S, Thowai A S,<br>Moulee S T, Jahan A, Khatun A, Sarkar M, Bibi S,<br>Tabassum T T, Nurunnabi M. Knowledge, Attitude,<br>and Practices Regarding Dengue Infection: A<br>Community-Based Study in Rural Cox’s Bazar. J<br>Commun Dis. 2025;57(1):121-130.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202516</p> Ely PrueA L Asmaul Husna Shazia RokonyAung Sain ThowaiShahra Tanjim MouleeAfsana JahanAysha KhatunMoloy SarkarSaima BibiTahsin Tasneem TabassumMohammad Nurunnabi
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2025-04-032025-04-03571121130Knowledge, Attitudes, and Practices (KAP) of Rural Communities on Dengue & Evaluating the Most Effective IEC Method for Its Prevention and Control in Delhi
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4402
<p>Background: Aedes mosquito prevalence in rural settings of Delhi is<br>strongly related to the changing lifestyle and ongoing urbanisation in<br>rural areas. Adequate awareness of dengue - its signs and symptoms<br>help in curbing the disease and seeking early and appropriate medical<br>assistance to save lives.<br>Methods: The study was conducted in rural areas of 3 zones namely<br>Narela zone, Najafgarh zone and Civil Lines zone of the Municipal<br>Corporation of Delhi. For assessing the most suitable Information<br>Education & Communication (IEC) activity, the knowledge level of</p> <p>selected individuals was assessed using a semi-structured, self-<br>administered questionnaire. It was followed by different IEC package</p> <p>materials. Based on the responses of villagers, the total score of each<br>villager was calculated. If the mean score of individuals was more than<br>50% then the villager was marked as having average awareness.<br>Result: Around 72% of individuals lack awareness regarding Aedes<br>mosquito breeding habitats and its role, being the vector agent for<br>dengue fever. Fever was reported by 59% of the study population.<br>Mosquito-repellent coils and mats were used by 33% of respondents.<br>Almost all of them used it during nighttime. Awareness about symptoms<br>of dengue fever improved from 26% of villagers in pre-IEC to 84% of<br>villagers in the post-IEC survey through the chaupal meeting method<br>of IEC as compared to other IEC methods.<br>Conclusion: This study can be an important source of baseline<br>information. Based on the findings of this study, now MCD may focus<br>on IEC campaigning through chaupal meetings with villagers to control<br>the transmission of diseases in villages.</p> <p>How to cite this article:<br>Handa A, Ahir S P, Verma L R. Knowledge, Attitudes,<br>and Practices (KAP) of Rural Communities on<br>Dengue & Evaluating the Most Effective IEC<br>Method for Its Prevention and Control in Delhi.<br>J Commun Dis. 2025;57(1):131-136.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202517</p>Ajay Handa S P AhirL R Verma
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2025-04-032025-04-03571131136Molecular Characterisation of Enterobacter Species Associated with Community-Acquired Urinary Tract Infection
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/3695
<p>Background: The most typical diseases brought on by Enterobacterales<br>are urinary tract infections (UTIs), which include community-acquired<br>and hospital-associated infections. Numerous such infections are caused<br>by the Enterobacter species, which is a member of ESKAP pathogens<br>known for antibiotic resistance. The current study aims to accurately<br>characterise Enterobacter spp., implicated in community-acquired<br>UTIs, by genetic methods.<br>Patients and Methods: A total of 50 midstream urine specimens were<br>collected from patients with uncomplicated UTIs. Specimen collection<br>was conducted from August to September 2022. The samples were<br>cultured on selective culture media under aerobic conditions for 24<br>hours at 37 °C. The isolates were primarily identified by standard<br>bacteriological methods. The molecular study included bacterial genomic<br>DNA extraction and the use of specific primers for the amplification of<br>465 bp of 16S rRNA gene, and sequencing along with the construction<br>of a phylogenetic tree.<br>Results: Out of 50 urine specimens, only 7 gave positive culture results<br>for Enterobacter spp. (14%), encompasses Enterobacter spp. 4 (57.1%)<br>and Enterobacter cloacae 3 (42.8%). These isolates were confirmed by<br>PCR for 16S rRNA gene and sequencing.<br>Conclusion: This 16S rRNA–based inclusive tree has provided an<br>extremely inclusive tool about the high ability of such genetic fragments<br>to efficiently identify Enterobacter spp. using this genetic fragment.</p> <p>How to cite this article:<br>Ibraheam I A, Bermani O K A L, Banimuslem T A,<br>Alsaadi Z H, Saad A M. Molecular Characterisation<br>of Enterobacter Species Associated with<br>Community-Acquired Urinary Tract Infection. J<br>Commun Dis. 2025;57(1):137-143.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202518</p>Israa Adnan IbraheamOruba K. Al-BermaniThikra Adnan BanimuslemZainab H. AlsaadiAli Malik Saad
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2025-04-032025-04-03571137143 Social Problem among Hepatitis C and B Virus Patients
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/3578
<p>Introduction: Hepatitis B and C infections pose significant global<br>health burdens, particularly affecting liver health and often remaining<br>asymptomatic, earning them the label “silent killers.” This study aimed<br>to assess the social challenges faced by hseepatitis B and C patients<br>in Baghdad, Iraq.<br>Methods: Conducted from December 2023 to January 2024, the</p> <p>study employed a quantitative, nonexperimental, descriptive cross-<br>sectional design. Purposive sampling was used to select participants</p> <p>from Baghdad Governorate’s Medical City Department/ Digestive<br>and Liver Teaching Hospital. Data were collected through structured<br>questionnaires covering socio-demographics and social parameters.<br>Results: The study revealed that hepatitis patients, predominantly males,<br>face moderate to high levels of loneliness, with a significant impact on<br>their emotional well-being. While they perceive moderate social support,<br>they struggle with feelings of isolation and social disengagement.<br>However, their social relationships with family and community remain<br>moderately intact, similar to healthy individuals.<br>Conclusion: These findings underscore the need for holistic care<br>approaches addressing not only the physical but also the social aspects<br>of hepatitis management to improve patients’ overall well-being and<br>quality of life.</p> <p>How to cite this article:<br>Kadem A Y, Turki S G. Social Problem among<br>Hepatitis C and B Virus Patients. J Commun Dis.<br>2025;57(1):144-150.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202519</p>Ahmed Yaqoub Kadem Salwa Ghazi Turki
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2025-04-032025-04-03571144150Detection of Virulence Genes in Klebsiella pneumoniae and Staphylococcus aureus Isolated from Urinary Catheterised Patients
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4251
<p>Background: One of the most predominant health-related illnesses</p> <p>universally is catheter-associated urinary tract infection (CAUTI). CAU-<br>TIs constitute over 50% of all hospital-acquired infections. Majority of</p> <p>the healthcare-acquired urinary tract infections result from catheter<br>tubes implantation.<br>Objective: To reveal the existence and frequency of the fimH, Ycfm,<br>clfA, and Cap5 genes in two species isolated from patients with urinary<br>catheters.<br>Methods: During the period from November 2023 to February 2024,</p> <p>a total of 50 samples of urine were collected from patients with uri-<br>nary catheters at Tikrit Teaching Hospital and private clinics in Salah</p> <p>Al-Deen province, Iraq. Different antibiotics were used to examine the<br>antibiotics sensitivity test for bacterial isolates.<br>Results: Among the participants, 30 (60%) were female and 20 (40%)<br>were male, with ages ranging between 18 to 80 years and a mean age</p> <p>of 42.06± 14.6 years. Sensitivity for isolates of S. aureus to antibiot-<br>ics was 100% for amoxicillin, 66.6% for trimethoprim, and 44.4% for</p> <p>gentamicin and nitrofurantoin. 11.1% of isolates showed resistance<br>to ciprofloxacin. Among the K. pneumoniae isolates, 66.6 % exhibited</p> <p>resistance to amoxicillin and trimethoprim, while 11.1% showed resis-<br>tance to ciprofloxacin. Molecular analysis was done for 2 isolates of S.</p> <p>aureus and 2 isolates of K. pneumoniae based on their high resistance<br>to antibiotics. The results revealed that the clfA gene was found in<br>100% of S.aureus isolates, while the Cap5 gene was found in 50% of<br>S.aureus isolates. Also, the result unveiled that 100% of K. pneumoniae<br>isolates produced FimH-1 and Ycfm genes.<br>Conclusion: S. aureus and K. pneumoniae are common causes of urinary<br>tract infections in patients with urinary catheters. Virulence genes have<br>an important role in the pathogenicity of S. aureus and K.pneumoniae<br>in patients with urinary catheters.</p> <p>How to cite this article:<br>Khuder H S, Khudhur S S. Detection of<br>Virulence Genes in Klebsiella pneumoniae<br>and Staphylococcus aureus Isolated from<br>Urinary Catheterised Patients. J Commun Dis.<br>2025;57(1):222-230.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202529</p>Huda Saleh khuderShaimaa Saleh Khudhur
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2025-04-042025-04-04571222230Association between Vitamin D and Dengue Severity: A Systematic Review and Meta-Analysis Protocol
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4476
<p>Purpose: To understand how vitamin D influences the severity of dengue<br>fever as per WHO 1997 and WHO 2009 classification, as many studies<br>have shown ambiguity in this respect<br>Method: The review has been registered in PROSPERO with registration<br>number CRD420251003676 and will be carried out in accordance with<br>the PRISMA (Preferred Reporting Items for Systematic Reviews and<br>Meta-Analyses) 2020 standards. Peer-reviewed literature will be used<br>to identify the studies. The literature search will be conducted using<br>the following databases: Web of Science, PubMed, PubMed Central,<br>and Scopus. Additionally, the academic search engine - Google Scholar<br>will be searched.; two reviewers independently will screen the titles<br>and abstracts of studies based on predefined eligibility criteria. The<br>other two reviewers will assess the quality based on the Joanna Briggs<br>Institute quality parameters. Heterogeneity among the included studies<br>will be examined using statistical measures such as I2</p> <p>and Cochrane Q<br>statistics. Sensitivity and subgroup analysis will be used to assess the<br>findings’ reliability. If there are more than ten articles, a funnel plot<br>test will be employed to assess publication bias.<br>Conclusion: This systematic review and meta-analysis, in the absence<br>of multi-centric studies, will explore whether Vitamin D deficiency<br>worsens dengue outcomes and if supplementation could help. The<br>findings from this study could help shape future treatments and improve<br>patient care. In areas where dengue is endemic, our systematic review<br>and meta-analysis will assist in pinpointing research gaps and direct<br>future studies and public health initiatives.</p> <p>How to cite this article:<br>Agarwal S J, Jena P K, Kishore J, Sahu L S, Behera<br>C K, Panda S K, Agarwal V. Association between<br>Vitamin D and Dengue Severity: A Systematic<br>Review and Meta-Analysis Protocol. J Commun<br>Dis. 2025;57(1):151-156.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202520</p>Sonam Jalewa AgarwalPratap Kumar JenaJugal KishoreLlalli Smruti SahuChinmay Kumar BeheraSantosh Kumar PandaVishal Agarwal
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2025-04-032025-04-03571151156Atypical Presentations of Tinea Incognito
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4294
<p>Dermatophytosis is a prevalent superficial fungal infection involving<br>20–25% of the worldwide population, attributed to various species of<br>dermatophytes, such as Trichophyton, Microsporum and Epidermophyton.<br>However, its clinical presentations in immunocompromised individuals<br>or those resorting to topical and systemic corticosteroids often mimic<br>other dermatoses such as exfoliative dermatitis (ED), dermatophytosis<br>incognito, inflammatory, or neoplastic conditions, leading to delayed or<br>mismanagement in treatment. This review focuses on the prevalence of<br>atypical presentations of tinea incognito and their diagnostic evaluations<br>highlighted through relevant case reports from the year 2019 to 2024.</p> <p>How to cite this article:<br>Sindhuja R L, Rajasekaran K, Manickam<br>N, Vellaisamy S G, Gopalan K. Atypical<br>Presentations of Tinea Incognito. J Commun<br>Dis. 2025;57(1):157-166.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202521</p>Ravulapalli Lakshmi SindhujaKeerthana Rajasekaran Navakumar Manickam Seethalakshmi Ganga VellaisamyKannan Gopalan
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2025-04-032025-04-03571157166Current Status of Communicable Diseases – International, National and Kerala Scenarios
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4085
<p>Communicable diseases (CDs) are illnesses caused by certain contagious<br>agents that spread from infected people, animals or contaminated<br>environments to exposed individuals. Transmission can occur directly or<br>indirectly through various methods, including contact, air-borne particles,<br>contaminated objects, or intermediary organisms. CDs are the most<br>important cause of morbidity and mortality around the globe. Infectious<br>diseases, once the leading public health issue in developed nations,<br>have become less prevalent. However, the advent of new infectious<br>diseases poses new threats, while communicable diseases continue to<br>be a major health issue in developing countries. Kerala has experienced<br>an alarming rise in morbidity and mortality due to communicable<br>diseases during the past decade. The state has encountered periodic<br>outbreaks of various infectious diseases, including Nipah, West Nile,<br>and Zika viruses. Additionally, the emergence of Primary Amoebic<br>Meningoencephalitis (PAM) as a public health threat and the endemic<br>status of dengue and leptospirosis in all fourteen districts emphasise<br>the rising challenges in disease control. Communicable disease control<br>requires a multi-faceted approach including vigilant surveillance, rapid<br>detection, and thorough investigation. Promoting good hygiene practices<br>through IEC and BCC, as well as providing prompt treatment, care and<br>support to affected individuals are essential components. This paper<br>offers a thorough examination of communicable diseases worldwide,<br>in India, and specifically in Kerala.</p> <p>How to cite this article:<br>Rajendran R, Anusree S B, Sasi M S, Devi D S, Regu<br>K. Current Status of Communicable Diseases –<br>International, National and Kerala Scenarios. J<br>Commun Dis. 2025;57(1):167-184.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202522</p>R RajendranS B AnusreeM S SasiD Sheela DeviK Regu
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2025-04-032025-04-03571167184Free-Roaming Dog Versus Stray Dog: Which is better terminology for Rabies control?
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4223
<p>Introduction: Dogs have been an integral part of human life and human<br>settlements. Free-roaming dogs, often lack formal ownership but<br>remain integral to their surroundings. However, inconsistent terms like<br>“stray” or “feral” shape public attitudes, frequently leading to neglect<br>and harmful interventions. This review examines how language plays<br>a role in shaping public health strategies and attitudes toward dogs,<br>focusing on humane rabies control.<br>Methods: Using a narrative review approach, the study examines<br>research articles, policy documents, and legal frameworks like the<br>Prevention of Cruelty to Animals Act (1960), to assess the definitions,<br>cultural attitudes, and rabies prevention strategies for humane<br>management practices.<br>Results: Free-roaming dogs are diverse, ranging from independent<br>feral dogs to community dogs cared for informally. Many remain<br>unvaccinated and unmonitored, perpetuating rabies transmission.<br>Achieving 70% vaccination coverage is critical to breaking this cycle.<br>Success stories from Bhutan and Bali illustrate how humane strategies<br>such as mass vaccination and sterilization outperform harmful practices<br>like culling. Shifting from “stray dog” to “free-roaming dog” encourages<br>compassion, redefines public perceptions, and supports effective<br>management.<br>Conclusion: Aligning societal attitudes with humane legal frameworks<br>fosters safer communities for humans and dogs alike. Adopting<br>compassionate language and strategies promotes coexistence, protects<br>public health, and ensures that free-roaming dogs are treated with<br>dignity and respect. This simple change in terminology inspires a broader<br>cultural shift toward humane treatment and sustainable solutions.</p> <p>How to cite this article:</p> <p>Jena P K, Agarwal S J, Kishore J, Sahu L S. Free-<br>Roaming Dog Versus Stray Dog: Which is better</p> <p>terminology for Rabies control?. J Commun Dis.<br>2025;57(1):185-190.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202523</p> Pratap Kumar JenaSonam Jalewa Agarwal Jugal KishoreLlalli Smruti Sahu
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2025-04-032025-04-03571185190Helicobacter pylori Eradication Therapies: Current Strategies and Future Perspectives in Peptic Ulcer Disease
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4115
<p>Helicobacter pylori (H. pylori) infection is a significant global health</p> <p>concern, linked to peptic ulcers, gastric adenocarcinoma, and mucosa-<br>associated lymphoid tissue lymphoma. Standard triple therapy with</p> <p>proton pump inhibitors (PPIs) and antibiotics, while effective in many<br>cases, faces rising failure rates due to antibiotic resistance, patient<br>non-compliance, and adverse side effects. Quadruple and sequential<br>therapies have been introduced, utilising additional agents like bismuth<br>and adjusting antibiotic administration. However, these regimens still<br>confront challenges, including drug resistance and high recurrence rates.<br>Probiotics, particularly Lactobacillus strains, have emerged as potential<br>adjuncts to standard therapy, and they have been shown to enhance<br>eradication rates and reduce side effects. Alternative therapies like<br>vonoprazan, a potassium-competitive acid blocker, and personalised<br>dosing based on body size and genetic factors, particularly CYP2C19<br>variations, are under investigation to optimise efficacy. Innovative<br>strategies, such as antibiotic stewardship guided by susceptibility<br>testing, have also been proposed to enhance treatment outcomes<br>while mitigating resistance. Patient education on adherence and proper<br>medication usage has been shown to significantly impact eradication<br>success rates. Additionally, broad eradication programmes aimed at<br>high-risk populations have demonstrated substantial reductions in<br>gastric cancer incidence and mortality, emphasising lifestyle adjustments<br>and early detection. As research advances, future therapies may<br>include antivirulence agents targeting H. pylori’s virulence factors and<br>new mucolytic drugs, promising better outcomes while preserving gut<br>microbiota. Overall, a multifaceted approach incorporating personalised<br>medicine, probiotic adjuncts, and patient-focused strategies appears<br>essential for effectively managing H. pylori infection and minimising<br>associated health risks.<br>How to cite this article:<br>Arun A, Rajesh N, Sreedevi M, Kardar K, Rakesh<br>A, Suresh S, Unnikrishnan V, Nawal A G, Menon L.<br>Helicobacter pylori Eradication Therapies: Current<br>Strategies and Future Perspectives in Peptic Ulcer<br>Disease. J Commun Dis. 2025;57(1):191-196.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202524</p>Akhil ArunNimsha RajeshSreedevi MKhadeeja KardarAishwarya RakeshSangeetha SureshVishnu UnnikrishnanNawal AGLakshmi Menon
Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138)
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2025-04-032025-04-03571191196Possibility of Invasion of Oropouche Virus (OROV) in Asia: A Real-Time Assessment is an Imperative Necessity
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4195
<p>Oropouche orthobunyavirus (OROV), a viral pathogen from the<br>Peribunyaviridae family, is emerging as a public health concern in<br>South and Central America, particularly Brazil and Peru, since its<br>identification in 1955 in South America. The virus is primarily transmitted<br>by the midge Culicoides paraensis, though mosquitoes like Culex<br>quinquefasciatus, Aedes aegypti, and Aedes albopictus might have<br>the potential to play roles as complementary and/ or maintenance<br>vectors. OROV has been reported to have infected more than half<br>a million people to date and causes clinical symptoms viz. fever,<br>headache, joint pain, and rash, similar to those of other endemic<br>mosquito-borne diseases, thus presenting diagnostic dilemmas. The<br>detection of OROV in the saliva and urine of infected individuals further<br>highlights its complex transmission dynamics. The reports of sloths and<br>primates serving as reservoir hosts in South America raise a warning<br>bell regarding its potential adaptability to new hosts viz. rodents and<br>bats if it gets introduced to Asia. Furthermore, the increasing global<br>trade and travel threatens to enhance the possibility of the risk of<br>OROV for cross-continental transmission, which has been clearly<br>evidenced by the recent cases reported amongst travellers returning<br>from South America to Europe and the United States. The diagnostic<br>confusion with other endemic mosquito-borne diseases like dengue and<br>chikungunya, complicates its detection and the ensuing control efforts.<br>The eco-climatic similarities between South America and Southeast<br>Asia strengthen the argument of the possible potential threat of OROV<br>establishing in Asia, especially India, where the suspected vector species<br>of OROV might support its transmission. There is, thus, an imperative<br>need for enhancing surveillance and monitoring, strengthening public<br>health preparedness, and undertaking research to alleviate the emerging<br>threat of OROV in Asia.</p> <p>How to cite this article:<br>Bhattacharya S, Chatterjee P, Tilak R. Possibility<br>of Invasion of Oropouche Virus (OROV) in Asia: A<br>Real-Time Assessment is an Imperative Necessity.<br>J Commun Dis. 2025;57(1):197-202.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202525</p>Sajal BhattacharyaPallab ChatterjeeRina Tilak
Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138)
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2025-04-032025-04-03571197202Unravelling the Nexus: A Comparative Analysis of Diabetes Mellitus and Its Impact on Respiratory Infection Susceptibility and Outcomes
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4120
<p>Diabetes mellitus (DM) is a global health crisis that not only affects<br>blood glucose regulation but also significantly impacts various organs<br>and body systems, including immune function. One of the most<br>concerning complications of DM is an increased susceptibility to<br>infections, particularly respiratory infections. These infections, ranging<br>from pneumonia to viral respiratory infections such as influenza and<br>tuberculosis (TB), and fungal infections like aspergillosis, tend to be more<br>severe in diabetic individuals, leading to prolonged illness, increased<br>hospitalisation, and mortality. This article provides a comparative<br>analysis of the mechanisms through which diabetes impacts respiratory<br>infection susceptibility, explores the types of respiratory infections<br>that are most common in diabetic patients and offers an in-depth<br>look at the clinical consequences of these infections. Furthermore, we<br>discuss innovative approaches to managing and preventing respiratory<br>infections in individuals with diabetes, including novel vaccines, precision<br>medicine, and integrated care models.</p> <p>How to cite this article:<br>Thomas R P, Venkatachari K M, Ganamoorth S,<br>Sivaji R K. Unravelling the Nexus: A Comparative<br>Analysis of Diabetes Mellitus and Its Impact on<br>Respiratory Infection Susceptibility and Outcomes<br>J Commun Dis. 2025;57(1):203-212.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202526</p>Rajeev P ThomasKumudhavalli Manni VenkatachariSanjay GanamoorthiRanjith Kumar Sivaji
Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138)
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2025-04-032025-04-03571203212A Complex Infectious Case of Dengue Fever with Thrombocytopenia, Acute Hepatitis A, Influenza B, URTI(Upper Respiratory Tract Infection), and Secondary HLH (Hemophagocytic Lymphohistiocytosis): A Diagnostic Challenge
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4168
<p>Worldwide, dengue is the most frequent trigger for viral haemorrhagic<br>fever. Although it is chronic in many tropical nations, instances from<br>non-endemic areas have also been documented on a regular basis in<br>recent years. Nonetheless, the World Health Organization’s revised<br>classification of dengue splits it into three groups: severe dengue,<br>dengue with warning signals, and dengue without warning signs.<br>Significant dengue is defined as those who have a significant vascular<br>leak, hypotension, severe bleeding, or severe organ involvement.<br>Hepatitis, the influenza virus, respiratory infections, liver failure, and<br>Hemophagocytic lymphohistiocytosis (HLH) linked to dengue fever<br>have all been documented; most of these cases involved children, with<br>a small number of adult case reports. Fatal results including a 50%<br>mortality rate have been documented in the child’s research. Here we<br>have presented a case of a 17-year-old teenager with dengue fever and<br>co-morbidities of hepatitis, influenza, lung diseases, and HLH.</p> <p>How to cite this article:<br>Gadhiya H, Radhanpura Y, Parekh K, Trigar P.<br>A Complex Infectious Case of Dengue Fever<br>with Thrombocytopenia, Acute Hepatitis A,<br>Influenza B, URTI(Upper Respiratory Tract<br>Infection), and Secondary HLH (Hemophagocytic<br>Lymphohistiocytosis): A Diagnostic Challenge. J<br>Commun Dis. 2025;57(1):213-216.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202527</p>Harshil GadhiyaYash RadhanpuraKushal ParekhPravin Tirgar
Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138)
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2025-04-032025-04-03571213216Identifying New Common Mosquito Breeding Sites in Flood-Affected Areas of Shahdara South Zone of MCD and Adopted Strategies for Preventing and Controlling Dengue Malaria Cases in the Year 2023
https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4323
<p>Flooding significantly alters ecosystems, creating new potential habitats<br>for mosquitoes. These changes can increase the risk of vector-borne<br>diseases such as malaria, dengue, and chikungunya. This paper discusses<br>a case study of a Yamuna flood-affected area in Delhi to identify new<br>common mosquito breeding sites and adopted strategies for the<br>prevention and control of vector-borne diseases. We have examined<br>the post-flooding environmental changes, the types of new breeding<br>sites, and proposed methods for the identification and control of these<br>sites to mitigate the associated health risks.</p> <p>How to cite this article:<br>Mishra S, Kohli S. Identifying New Common<br>Mosquito Breeding Sites in Flood-Affected Areas<br>of Shahdara South Zone of MCD and Adopted<br>Strategies for Preventing and Controlling Dengue<br>Malaria Cases in the Year 2023. J Commun Dis.<br>2025;57(1):217-221.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202528</p>Saurabh Mishra Shalini Kohli
Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138)
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2025-04-032025-04-03571217221