Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases <p>The <em><strong>Journal of Communicable Diseases</strong> has been indexed in <strong>SCOPUS</strong>.</em></p> <p><a href="https://www.scopus.com/sourceid/22422">https://www.scopus.com/sources.uri</a></p> <p><strong>UGC Approved Journal</strong></p> en-US Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) 0019-5138 A Descriptive Study to Assess the Prevalence of Fungal Infections among Patients with Diabetes Mellitus and Hypertension and Their Risk Factors in a Community of Delhi https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4086 <p>Introduction: Diabetic patients are at higher risk of various health<br>problemsincluding fungal infections. Fungal infections are taken less<br>seriously but if not identified and treated promptly, may lead to resistant<br>infections, further complications and impaired quality of life.<br>Objectives: To assess the prevalence of fungal infections among diabetic<br>patients and risk factors of hypertension and diabetes mellitus<br>Methods: A descriptive survey research design was used. The study was<br>conducted among people residing in a selected area of Delhi. A purposive<br>sampling technique was used to collect 313 samples. A structured<br>interview schedule was used to collect the data,. Permission was<br>obtained from local authorities. An informed consent was obtained prior<br>to study participation. Data was analysed using descriptive statistics.<br>Results: 28.1% of people are suffering from diabetes, and out of those<br>only 88.6 % of people are taking medication. A total of 90.9% of diabetic<br>participants had a fungal infection. Out of that, 18.7 % had fungal<br>infections more than once a month,33.7 % were not taking any treatment<br>for fungal infection, 31.2% were taking home and natural remedies,<br>22.5 % were using topical antifungal creams (some containing steroids)<br>or suppositories and 12.5% were taking oral anti-fungal medication.<br>Conclusion: Diabetic patients have increased susceptibility to various<br>infections, including fungal infections emphasising the need for<br>comprehensive research and effective management strategies. This<br>study highlights the need for effective preventive strategieswhich could<br>significantly reduce healthcare costs and improve patients’ quality of life.</p> <p>How to cite this article:<br>John N, Rani S, Bhattarcharya S, Negi A. A<br>Descriptive Study to Assess the Prevalence of<br>Fungal Infections among Patients with Diabetes<br>Mellitus and Hypertension and Their Risk<br>Factors in a Community of Delhi. J Commun<br>Dis. 2025;57(1):1-8.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202501</p> Seema Rani Neha John Suchhanda Bhattarcharya Arushi Negi Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 1 8 Aedes-borne disease awareness in Thiruvarur District of Tamil Nadu, India https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/3064 <p>Background: In India, vector-borne diseases account for the high burden<br>of all infectious diseases (WHO, 2020). Among these, Dengue Fever<br>(DF) is the most common viral disease transmitted by Aedes spp. such<br>as Aedes aegypti and Aedes albopictus.<br>Aim of the study: This study aimed to identify and assess the Knowledge,<br>Attitude, and Practices (KAP) of Dengue fever among the University /<br>College students in Thiruvarur district, Tamil Nadu, India.<br>Methods: A cross-sectional study was conducted at 13 University/<br>Colleges from Thiruvarur district. The targeted study group was above<br>the age group of 17 years from the rural and urban settings of Thiruvarur<br>district. The study instrument contains a questionnaire on knowledge,<br>attitude, and practices regarding Dengue fever in university/ college<br>students.<br>Results: In the present study, the prime source from which the students<br>received information on Dengue Knowledge was from TV (68.6%). There<br>was significant association between knowledge level and educational<br>level (X2<br>= 3.964, df=1, p &lt; 0.05), between knowledge, attitude and<br>practices with the Institutional type (X2</p> <p>= 4.35, 6.315, 6.662 df=1, p &lt;</p> <p>0.05) and between practices and gender (X2</p> <p>= 3.866 df=1, p &lt; 0.05). There<br>was positive moderate correlation between Knowledge and Attitude<br>(r=0.441), between Attitude and Practice (r=0.606), and there was a<br>positive weak correlation between Knowledge and Practice (r=0.374).<br>Conclusion: Despite having sufficient knowledge regarding dengue<br>fever, students is still lacking in the knowledge of vector transmission<br>and breeding grounds. This suggests that the public health authorities<br>should implement future intervention strategies and conduct health<br>education programs.</p> <p>How to cite this article:<br>Liston F D O R, Hatibaruah A, Jeevith S B, Farhat<br>S K, Anbalagan R, Philip N E, Krishnan J, Binduja<br>S. Aedes-borne disease awareness in Thiruvarur<br>District of Tamil Nadu, India. J Commun Dis.<br>2025;57(1):9-19.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202502</p> Liston FDO R Ananya Hatibaruah Sathya Jeevitha B Farhat S K Rajalakshmi Anbalagan Neena Elezebeth Philip Jayalakshmi Krishnan Binduja S Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 9 19 An Integrated Multi-Agent Frameworks for COVID-19 Detection Using Machine Learning and Deep Learning Techniques https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4328 <p>The SARSCoV-2 virus causes the infectious illness known as coronavirus<br>disease (COVID-19). In recent decades, COVID-19 has become the most<br>infectious disease. Millions of individuals worldwide suffer from this<br>disease. Because of the restricted availability and sensitivity of testing<br>kits, doctors and researchers have turned to computer tomography<br>(CT) scans to screen for COVID-19. Recent technological developments<br>and the widespread use of machine learning (ML) and deep learning<br>(DL) techniques have shown high potential in terms of more accurate<br>COVID-19 detection. Therefore, in this paper, we have developed two<br>multi-agent frameworks for COVID-19 detection using the ML and DL<br>algorithms. In the first framework, several ML algorithms, namely, KNN,</p> <p>LR, and SVM, are employed. Further, ensemble learning and hypertun-<br>ing of the ML algorithms is done using the grid search method. Next,</p> <p>reinforcement learning method Q learning agent is used to update the<br>multi-agent framework. On the other hand, the second multi-agent<br>framework is developed with the help of lightweight ResNet and<br>reinforcement PPO algorithms. Further, in both frameworks, feature<br>selection is done using the LRP-ET method to determine the appropriate<br>features from the dataset. The experimental results are performed on<br>the Google Colab software for the standard dataset. The dataset is split<br>into an 80:20 ratio to train and test the frameworks. The evaluation<br>of both frameworks is done using the various parameters, namely,<br>accuracy, precision, recall, and F-score. The results show that both<br>frameworks outperform the existing models. Finally, the comparison<br>of both frameworks shows that the second framework, which is based<br>on deep learning, performs superiorly over the first framework, which<br>is based on ML, due to efficiently handling complex data.</p> <p>How to cite this article:<br>Walia R K, Kaur H. An Integrated Multi-Agent<br>Frameworks for COVID-19 Detection Using<br>Machine Learning and Deep Learning Techniques.<br>J Commun Dis. 2025;57(1):20-32.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202503</p> Rupinder Kaur Walia Harjot Kaur Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 20 32 Beyond the Epidemic Diseases Act, 1897: Rethinking India’s Public Health Laws for Pandemic Preparedness – Lessons from Singapore https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4447 <p>The Epidemic Diseases Act (EDA), 1897, was enacted in the late 19th<br>century in the wake of the third plague pandemic in India and was<br>a significant step in colonial public health legislation. However, more<br>than a century later, the COVID-19 pandemic laid out how outdated<br>this law is for addressing current public health challenges. This research<br>article examines the historical antecedents and shortcomings of the<br>EDA, 1897, and compares India’s public health response with that of<br>a country like Singapore which has a comprehensive and exhaustive<br>approach to tackling public health through a legal mandate under<br>the Infectious Diseases Act, 1976. The article also examines the<br>Public Health (Prevention, Control and Management of Epidemics,<br>Bio-terrorism and Disasters) Bill, 2017 which tried to replace the EDA</p> <p>but never came into being due to its centralisation of power and non-<br>consultation with civil society. The study compares the effectiveness</p> <p>of lockdown measures taken against the COVID-19 pandemic in both<br>countries through a comparative analysis of COVID-19 data and stresses<br>that legal frameworks, governance, and public accountability are<br>critical in the management of epidemics. The study further provides<br>practical suggestions to reinforce India’s public health system, focusing<br>on revamping legal provisions, strengthening healthcare infrastructure<br>capacities, upgrading Centre-State coordination, and ensuring India<br>has access to devolved and contextual measures in future crises.<br>Adaptation of world-class practices including that of Singapore can<br>help India build a future-ready proactive public health system that can<br>ensure protection for its population against future health challenges.</p> <p>How to cite this article:<br>Anand A, Ranjan P, Kumar R. Beyond the Epidemic<br>Diseases Act, 1897: Rethinking India’s Public<br>Health Laws for Pandemic Preparedness – Lessons<br>from Singapore. J Commun Dis. 2025;57(1):33-43.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202504</p> Ankit Anand Priya Ranjan Rajneesh Kumar Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 33 43 Biofilm Feast: Stringent Response-Induced Changes in MRSA and MSSA Isolates, Examining icaA/ icaD Gene Expression https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/3413 <p>Introduction: The stringent response is a bacterial adaptation mechanism<br>triggered by stress conditions, including nutrient limitation. This<br>response helps bacteria survive under harsh conditions, such as those<br>encountered during infection. A key feature of the stringent response<br>is the synthesis of the alarmone (p)ppGpp, which influences various<br>bacterial phenotypes. In several bacterial species, stringent response<br>activation significantly affects biofilm formation and maintenance.<br>Methods: Clinical specimens were collected from multiple hospitals in<br>Baghdad, Iraq. Staphylococcus aureus was identified using conventional<br>biochemical tests. The PCR technique was applied to detect mecA,<br>icaA, and icaD genes, while the Vitek 2 compact system confirmed<br>Methicillin sensitivity in mecA-negative isolates. Biofilm intensity of all<br>S. aureus isolates was assessed under normal and starved conditions.<br>Additionally, the gene expression levels of icaA and icaD were measured<br>in five MRSA and five MSSA strains under both conditions.<br>Results: The mecA, icaA, and icaD genes were detected in 94%, 96.3%,<br>and 100% of S. aureus isolates, respectively. Biofilm production<br>analysis showed that 24% of isolates were strong producers, 49%<br>were moderate producers, and 9% were weak producers. Statistical<br>analysis indicated that biofilm intensity significantly decreased under<br>nutrient limitation (p &lt; 0.0001) compared to normal conditions across<br>all isolates. Furthermore, icaA and icaD genes were upregulated under<br>stringent response conditions, regardless of Methicillin resistance status.<br>Conclusion: The stringent response influences S. aureus biofilm<br>formation, with biofilm intensity decreasing under nutrient-limited<br>conditions. However, the upregulation of icaA and icaD genes suggests<br>a regulatory role of the stringent response in biofilm-related gene<br>expression. These findings highlight the potential impact of stress<br>adaptation mechanisms on bacterial persistence and pathogenicity.</p> <p><strong>How to cite this article:</strong><br>Mussa A A, Mathkhury H J F A. Biofilm Feast:<br>Stringent Response-Induced Changes in MRSA<br>and MSSA Isolates, Examining icaA/ icaD Gene<br>Expression. J Commun Dis. 2025;57(1):44-54.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202505</p> Ali A Mussa Harith Jabbar Fahad Al Mathkhury Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 44 54 Community Healthcare Providers’ Perspective on Malaria Control in Difficult Terrains (DAMaN) in Odisha, India https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4187 <p>Introduction: Malaria remains a major public health challenge, especially<br>in remote areas with limited healthcare. The WHO-endorsed Mass<br>Testing and Treatment (MTaT) strategy targets high-prevalence regions<br>by screening and treating entire populations. In India, Odisha’s DAMaN<br>programme integrates MTaT with health services to combat malaria in<br>tribal communities. This study explores community healthcare providers’<br>perspectives on MTaT under DAMaN.<br>Methods: The study involved 53 community health workers (CHWs)<br>from five districts, including Accredited Social Health Activists, Auxiliary<br>Nurse Midwives, and Community Health Officers. Data were analysed<br>using thematic analysis.<br>Results: Three themes emerged: 1) Equity in malaria service delivery</p> <p>among remote, hilly areas and vulnerable tribal populations, 2) Non-<br>malaria service benefits from mass testing and treatment of malaria</p> <p>in remote areas, and 3) Challenges and suggestions for addressing<br>implementation gaps. The DAMaN programme has significantly reduced<br>malaria prevalence and improved healthcare access in remote villages<br>by integrating malaria control with broader health services and fostering<br>community engagement. It has strengthened trust in public healthcare<br>systems and improved health outcomes. However, challenges like<br>infrastructure, workforce limitations, socio-cultural resistance, and<br>resource availability need to be addressed to sustain its impact.<br>Conclusion: Suggestions for improving scheduling flexibility, increasing<br>camp frequency, incentivising volunteers, and fostering inter-departmental<br>collaboration could further strengthen DAMaN’s effectiveness and<br>sustainability.</p> <p>How to cite this article:<br>Pradhan M M, Sahoo K C, Patra A, Nanda B, Bag,<br>Dey N, Sahu K, Pati S. Community Healthcare<br>Providers’ Perspective on Malaria Control in<br>Difficult Terrains (DAMaN) in Odisha, India. J<br>Commun Dis. 2025;57(1):55-64.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202506</p> Madan Mohan Pradhan Krushna Chandra Sahoo Annapurna Patra Nirupama Das Baladeba Nanda Kumuda Chandra Sahu Santosh Bagh Sanghamitra Pati Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 55 64 Comparative Analysis of Hepatitis E and A in Children: Clinical Manifestations and Epidemiological Patterns in Kyrgyzstan https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4421 <p>Introduction: Viral hepatitis E (HEV) poses a significant global health<br>challenge with limited research on its impact on children. This<br>retrospective study aimed to identify the clinical and laboratory features<br>of HEV in children and compare them with those of hepatitis A virus<br>(HAV) infections in the Kyrgyz Republic.<br>Methods: Clinical and laboratory data from children diagnosed with HEV<br>(n=31) and HAV (n=42) at the three regional hospitals were analyzed.<br>Results: HEV cases were predominantly male (74.1%), aged 1-5 years<br>(42%), and from rural areas (77.4%), while HAV showed no significant<br>gender or urban-rural disparity. HEV patients experienced a more severe<br>clinical course, with 13% classified as severe compared with 4.7% of HAV<br>cases. HEV infection resulted in prolonged symptom duration during<br>the pre-jaundice and jaundice phases, with longer periods of fever,<br>weakness, decreased appetite, vomiting, and abdominal pain (P&lt;0.05).<br>Blood biochemistry revealed higher total and indirect bilirubin levels<br>in HEV patients (P&lt;0.05) and lower total protein levels in severe HEV<br>cases (P&lt;0.05). The mean hospitalization duration was longer for HEV<br>(17.2±1.3 days) than HAV (12.7±1.2 days; P&lt;0.05).<br>Conclusion: The study found the clinical manifestations of children<br>with HEV were severe and longer in duration as compared to children<br>with HAV. These findings highlight the importance of timely diagnosis<br>of HEV and preventive measures, particularly in rural areas.</p> <p>How to cite this article:<br>Tashov K, Anarbaeva J, Murzakulova A,<br>Abdyraeva B, Tashpolotova A, Abdikerimov M,<br>Djumagulova A, Mambetova M, Suranbaeva<br>G, Vityala Y. Comparative Analysis of Hepatitis<br>E and A in Children: Clinical Manifestations<br>and Epidemiological Patterns in Kyrgyzstan. J<br>Commun Dis. 2025;57(1):65-72.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202507</p> Kursanali Tashov Jumagul Anarbaeva Altynai Murzakulova Baktygul Abdyraeva Anarkan Tashpolotova Mamazia Abdikerimov Anara Djumagulova Madina Mambetova Gulmira Suranbaeva Yethindra Vityala Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 65 72 Comparative Evaluation of Rapid Antigen Detection Assay and RT-PCR for SARS-CoV-2 Diagnosis in a Tertiary Care Setting https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4028 Pinki Kumari Jiwesh Kumar Thakur Aditya Kumar Jha Satyendra Prasad Yadav Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 73 78 Diversity and Distribution of the Aedes Vectors in the Coastal Sites of Puducherry, Southern India https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4077 <p>Introduction: Dengue poses a significant public health challenge<br>in Pondicherry. Understanding the distribution of Aedes mosquito<br>populations is critical for devising and implementing effective vector<br>control strategies.<br>Methods: This study aimed to measure the abundance of dengue<br>vectors through entomological surveillance methods and to evaluate<br>the potential for dengue virus transmission within the coastal regions<br>of Pondicherry. An entomological survey was carried out across nine<br>randomly selected localities within Puducherry, in and around the<br>premises, during 2019–2020, covering 180 households monthly.<br>Results: The analysis for the Adult Premise Index, per man hour density,<br>and correlation was calculated using the SPSS Version 16.0 for assessing<br>significant findings. The study found that Aedes mosquitoes infested<br>24.9% of the 537 positive houses. The adult density of Aedes mosquitoes<br>was 16.6 per 10 person-hours and the average number of mosquitoes<br>per house was 0.27 per 10 man-hours. The per-person-hour density<br>of Aedes mosquitoes varied from 8.0 to 23.7 and was more abundant<br>during monsoon months. Similarly, the adult premise index of Aedes<br>mosquitoes varied from 8.9 to 36.7 and did not differ significantly<br>in various months. Ae. aegypti was the predominant dengue vector<br>followed by Ae. albopictus, which was most prevalent in June and less<br>prevalent in February.<br>Conclusion: The current study provides valuable baseline data on the<br>abundance and distribution of dengue vectors in the coastal areas of<br>Pondicherry. Continued entomological surveillance is necessary to<br>monitor the effective of control measures and detect changes in vector<br>abundance and distribution over time.</p> <p>Velan I, Prasad P, Baskar V, Venkat V, Anil A,<br>Ragupathi L. Diversity and Distribution of the<br>Aedes Vectors in the Coastal Sites of Puducherry,<br>Southern India. J Commun Dis. 2025;57(1):79-84.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202509</p> Iyyappan Velan Pooja Prasad Vetrivel Baskar Vinoth Venkat Athira Anil Lokesh Ragupathi Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 79 84 Drug Susceptibility Testing of Mycobacterium Tuberculosis for Isoniazid and Rifampicin by Absolute Concentration and MTT method – A Comparative Study https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4170 <p>Introduction: Tuberculosis has been a main cause of mortality and<br>morbidity globally. In spite of having anti-tuberculous drugs, elimination<br>of tuberculosis is difficult because of the drug resistance. In order to<br>achieve vital therapy selection and prevention of resistance, expeditious<br>detection along with drug susceptibility techniques are essential needs<br>of the hour.<br>Aim: To evaluate the MTT assay and the absolute concentration method<br>for determining Mycobacterium tuberculosis susceptibility to rifampicin<br>and isoniazid<br>Methods: 71 isolates of Mycobacterium tuberculosis were tested for<br>susceptibility to the first-line medications isoniazid and rifampicin using<br>the MTT assay and the absolute concentration method after sputum<br>samples that tested positive for acid-fast bacilli were gathered.<br>Results: Of the 71 isolates, 14% (10) were resistant to isoniazid and<br>9% (6) were resistant to rifampicin by absolute concentration method.<br>Isoniazid resistance was seen in 13% (9) and 10% (7) were resistant to<br>rifampicin by MTT assay. Isoniazid mono resistance was observed in<br>5 isolates and 1 isolate to rifampicin alone by absolute concentration<br>method. Two isolates that were mono-resistant to rifampicin and four<br>isolates that were mono-resistant to isoniazid were acquired using the<br>MTT assay. Both the absolute concentration approach and the MTT<br>experiment revealed that 7% (5) of the isolates were multidrug resistant.<br>Conclusion: Increasing numbers of resistant and multidrug-resistant<br>tuberculosis (MDR-TB) strains have led to a daunting need for rapid,<br>reliable, and accurate drug susceptibility testing. Hence, we concluded<br>that the absolute concentration method is better than the MTT assay in<br>terms of simplicity of performance though the results may be delayed.</p> <p>How to cite this article:<br>Santharam P, Govindarajan V. Drug Susceptibility<br>Testing of Mycobacterium Tuberculosis<br>for Isoniazid and Rifampicin by Absolute<br>Concentration and MTT method – A Comparative<br>Study. J Commun Dis. 2025;57(1):85-90.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202510</p> Priya Santharam Vimal Govindarajan Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 85 90 Efficiently Predicting HIV-1 Protease Cleavage Sites by Using Deep CNN-Assisted Hybridised Approach https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4088 <p>Acquired Immuno Deficiency Syndrome (AIDS) is considered a vital<br>danger over the feasible development and on account of its pestilence<br>effect and nonattendance of reparable medicines. HIV-1 AIDS can be<br>constrained by utilising protease inhibitors. Different procedures for<br>predicting sites are utilised to comprehend the highlighted sites of those<br>proteases. Arrangement-based sites like physiochemical elements and<br>construction-based sites are separated from HIV-1 proteases. In this<br>article, a procedure for choosing those sites using a deep CNN-assisted<br>hybridised approach will be used for effectively predicting cleavage sites.<br>The proposed methodology was evaluated based on various Type-1 and<br>Type-2 parameters. The proposed approach gives superior results on<br>Type-1 and Type-2 parameters. Data746_setset provides an accuracy of<br>0.924, data 1625_set provides an accuracy of 0.946, Data_schilling_set<br>provides an accuracy of 0.9389, Data_impens_set provides an accuracy</p> <p>of 0.911 and average dataset provides an accuracy of 0.921 for Type-<br>1 parameters. Data746_setset provides an accuracy of 0.84664, data</p> <p>1625_set provides an accuracy of 0.34179, data_schilling_set provides<br>an accuracy of 0.69529 and data_impens_set provides an accuracy of<br>0.59511 for Type-2 parameters.</p> <p>Saini S, Kaur G. Efficiently Predicting HIV-1</p> <p>Protease Cleavage Sites by Using Deep CNN-<br>Assisted Hybridised Approach. J Commun Dis.</p> <p>2025;57(1):91-95.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202511</p> Navneet Kaur Bawa Satish Saini Gagandeep Kaur Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 91 95 Evaluating the Clinical Utility of C-Reactive Protein , Procalcitonin, and Presepsin as Biomarkers in Sepsis Diagnosis and Prognosis of the Infections https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4093 <p>Introduction: Sepsis, caused by an uncontrolled immune response,<br>leads to high mortality and poses challenges for early diagnosis due<br>to symptom variability. Standard blood cultures often fail, highlighting<br>the need for reliable biomarkers. This study assessed C-reactive protein<br>(CRP), procalcitonin (PCT), and presepsin to improve early detection<br>and minimise unnecessary antibiotic use.<br>Materials and Method: This retrospective study involved 100 patients<br>with sepsis in the Medical ICU, adhering to the American College of<br>Chest Physicians’ guidelines. Blood samples were analysed for CRP,<br>PCT, and presepsin using appropriate assays. Data were processed in<br>MS Excel and analysed with SPSS (version 25).<br>Results: Among the 100 patients (median age 42 years), 56% had sepsis,<br>18% severe sepsis, and 26% septic shock. Common comorbidities<br>included diabetes (21.4%) and hypertension (19.6%). Significant<br>biomarker differences were noted: PCT levels were highest in septic<br>shock (6.5 ng/mL), followed by severe sepsis (3.2 ng/mL) and sepsis (1.8<br>ng/mL) (p &lt; 0.001). CRP and presepsin levels also showed significant<br>variations. Sensitivity was 85% for CRP, 90% for PCT, and 92% for<br>presepsin, and specificity values were 70%, 75%, and 80%, respectively.<br>Conclusion: This study emphasises the varying efficacy of CRP, PCT, and<br>presepsin in diagnosing sepsis and its severity. The notable differences<br>in biomarker levels across sepsis stages highlight the importance of early<br>identification and intervention. Future research should investigate the<br>integration of these biomarkers with clinical scoring systems to improve<br>sepsis management and outcomes in infected persons.</p> <p>Singhal A K, Bansal S K, Harith A K, Saha T K.<br>Evaluating the Clinical Utility of C-Reactive<br>Protein , Procalcitonin, and Presepsin<br>as Biomarkers in Sepsis Diagnosis and<br>Prognosis of the Infections. J Commun Dis.<br>2025;57(1):96-100.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202512</p> A K Singhal SK Bansal A K Harith TK Saha Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 96 100 Evaluation of Treatment Outcomes in Shorter and Longer Regimen Treatment in Multi-Drug Resistant Tuberculosis (MDR-TB) Patients in District Etawah: A Longitudinal Study https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4232 <p><strong>Background:</strong> Multi-drug resistance tuberculosis is a worldwide problem with a notoriously difficult and challenging treatment. There are two treatment regimens for MDR-TB treatment.</p> <p><strong>Objectives:</strong> To compare the predisposing risk factors and treatment outcomes in two different drug regimens for the treatment of MDR-TB.</p> <p><strong>Material and methods:</strong> A field based longitudinal study was carried out among 50 microbiologically confirmed MDR-TB patients of age 18 years and above, enrolled from January 2020 to December 2020 of district Etawah. Variables recorded were socio-demographics, clinical profile and treatment outcomes.</p> <p><strong>Result: </strong>Mean age of the participants was 30.70±12.52 years. Most of the participants were female (58%) and belonged to Class II and III of Modified BG Prasad Classification. Most of the participants (62%) had BMI of &lt;18.5Kg/m<sup>2</sup>. About 93% of the study participants in the shorter regimen completed the treatment and were cured. The participants with no prior history of tuberculosis had better treatment outcome (p=&lt;0.001). <sup>&nbsp;</sup></p> <p><strong>Conclusion: </strong>The present study concludes that successful treatment outcome is more in shorter treatment regimen compared to longer treatment regimen.</p> <p><strong>Keywords:</strong> MDR-TB, shorter regimen, longer regimen, treatment outcomes, NTEP, India</p> Rahul Verma Dhiraj Kumar Srivastava Sandip Kumar Mohit Mishra Alankrita Acharya Ankur Baidya Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 101 108 Exploring Dentists’ Awareness and Approaches to Mucormycosis: A Post-COVID Orofacial Complication in the Context of Communicable Diseases https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4441 <p>Iintroduction: COVID-19 has increased opportunistic infections like<br>mucormycosis, especially in immunocompromised individuals. Dentists<br>play a key role in early detection and management of post-COVID<br>oral complications, yet their awareness of mucormycosis remains<br>underexplored.<br>Objective: This study assesses dentists’ knowledge, attitudes, and<br>practices regarding mucormycosis as a post-COVID orofacial complication.<br>Methods: A cross-sectional study analyzed dentists’ demographics,<br>awareness, and clinical practices on post-COVID mucormycosis. Data<br>were statistically analyzed using SPSS 21.0.</p> <p>Results: Among participants, 81.6% had a fair understanding of post-<br>COVID fungal infections, and 99.2% correctly identified mucormycosis.</p> <p>However, only 77.6% knew its diagnostic criteria. While 87% recognized<br>mucormycosis as a complication, 72.8% identified rhino-orbital-cerebral<br>mucormycosis as the most common type. Additionally, 73% were<br>aware of treatment protocols, but only 17.8% had screened patients<br>in the past year.<br>Conclusion: Although dentists show strong awareness, gaps exist in<br>clinical preparedness and diagnostic accuracy. Targeted training can<br>enhance early detection, intervention, and multidisciplinary collaboration<br>for better patient outcomes.</p> <p>How to cite this article:<br>Kumar M, Murugaiyan U, Jha A, Singh A,<br>Kumar B S, Venkatesh M, Arjun B, Kumari N.<br>Exploring Dentists’ Awareness and Approaches<br>to Mucormycosis: A Post-COVID Orofacial<br>Complication in the Context of Communicable<br>Diseases. J Commun Dis. 2025;57(1):109-114.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202514</p> Mukesh Kumar Uma Murugaiyan Abhinav Jha Abhishek Singh B SendilKumar M Venkatesh B Arjun Namrata Kumari Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 109 114 Haematological and Biochemical Parameters in COVID-19 Patients Attending a Tertiary Care Hospital: A Retrospective Study https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4319 <p>Introduction: The SARS-CoV-2 RNA virus, which causes COVID-19<br>disease, rapidly spread to the entire world. COVID-19 mainly involves the<br>respiratory tract, now found to be linked with systemic diseases due to<br>multiple organ involvement. Limited data are available regarding the effect<br>of COVID-19 on various haematological and biochemical parameters.<br>Materials and Methods: A retrospective cross-sectional study was carried<br>out on 400 cases from March 2021 to August 2021. Two hundred<br>COVID-19 RT-PCR confirmed cases formed the study group and 200<br>subjects who tested negative were included in the controls to study<br>various haematological and biochemical parameters.<br>Results: Thrombocytopenia was significantly noticed in cases as compared<br>to controls (65.3% and 34.7%, respectively), with cases 2.45 times more<br>likely to be thrombocytopenic (p &lt; 0.01). Leucopenia was 1.79 times<br>higher in cases (62.8%) in comparison to controls (37.2%). Moreover,<br>positive cases were 1.35 times more anaemic than control. The mean<br>indices for serum bilirubin (p = 0.020), serum creatinine (p &lt; 0.001),<br>alanine transaminase (p = 0.081), blood urea (p &lt; 0.001), procalcitonin<br>(p &lt; 0.001) and c-reactive protein (p &lt; 0.001) were significantly raised<br>in cases in comparison to controls.<br>Conclusion: Thrombocytopenia, leucopenia along with raised serum<br>bilirubin, creatinine, ALT, AST, CRP and procalcitonin may be beneficial<br>in the diagnosis of COVID-19. Meticulous assessment and correlation of<br>haematological and biochemical parameters at the time of admission and<br>simultaneously during the disease course will be helpful to physicians<br>in formulating individualised treatment along with decision-making<br>regarding requiring intensive care to those in need.</p> <p>How to cite this article:<br>Omhare A, Singh S, Yadav S K, Yadav K, Chaudhary<br>S, Mishra K L. Haematological and Biochemical<br>Parameters in COVID-19 Patients Attending a<br>Tertiary Care Hospital: A Retrospective Study. J<br>Commun Dis. 2025;57(1):115-120.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202515</p> Anita Omhare Shilpi Singh Suresh Kumar Yadav Kiran Yadav Sachin Chaudhary Kanhaiya Lal Mishra Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 115 120 Knowledge, Attitude, and Practices Regarding Dengue Infection: A Community-Based Study in Rural Cox’s Bazar https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4186 <p>Introduction: Dengue, an emerging infectious disease spread by<br>mosquitoes, poses a significant public health challenge, especially in<br>tropical and subtropical areas like Bangladesh.<br>Methods: We conducted a community-based cross-sectional study to<br>assess the levels of knowledge, attitude, and practice (KAP) towards<br>dengue infection among 484 adult rural people in the purposively<br>selected Shikderpara and Muhuripara villages, Cox’s Bazar. Face-to-face<br>interviews were performed at the convenience of study participants<br>using a pretested, semi-structured questionnaire.<br>Results: The mean age of participants was 33.3 ± 13.5 years, with<br>the majority (53.9%) extending between 18 and 34 years. About<br>two-thirds (72.9%) of the residents were literate. Most participants<br>demonstrated average knowledge (84.3%), a positive attitude towards<br>dengue infection (63.0%), and average prevention practices (57.2%).<br>There was a significant association between participants’ practice levels<br>and their knowledge and attitude (p &lt; 0.05), along with a statistically<br>significant correlation between their knowledge and dengue prevention<br>practices (p &lt; 0.05).<br>Conclusion: Although the attitude toward dengue infection was positive,<br>knowledge and practices were average. This can be improved by<br>promoting community participation and implementing comprehensive<br>public health measures at all levels.</p> <p>How to cite this article:<br>Pure E, Husna A L A, Rokony S, Thowai A S,<br>Moulee S T, Jahan A, Khatun A, Sarkar M, Bibi S,<br>Tabassum T T, Nurunnabi M. Knowledge, Attitude,<br>and Practices Regarding Dengue Infection: A<br>Community-Based Study in Rural Cox’s Bazar. J<br>Commun Dis. 2025;57(1):121-130.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202516</p> Ely Prue A L Asmaul Husna Shazia Rokony Aung Sain Thowai Shahra Tanjim Moulee Afsana Jahan Aysha Khatun Moloy Sarkar Saima Bibi Tahsin Tasneem Tabassum Mohammad Nurunnabi Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 121 130 Knowledge, Attitudes, and Practices (KAP) of Rural Communities on Dengue & Evaluating the Most Effective IEC Method for Its Prevention and Control in Delhi https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4402 <p>Background: Aedes mosquito prevalence in rural settings of Delhi is<br>strongly related to the changing lifestyle and ongoing urbanisation in<br>rural areas. Adequate awareness of dengue - its signs and symptoms<br>help in curbing the disease and seeking early and appropriate medical<br>assistance to save lives.<br>Methods: The study was conducted in rural areas of 3 zones namely<br>Narela zone, Najafgarh zone and Civil Lines zone of the Municipal<br>Corporation of Delhi. For assessing the most suitable Information<br>Education &amp; Communication (IEC) activity, the knowledge level of</p> <p>selected individuals was assessed using a semi-structured, self-<br>administered questionnaire. It was followed by different IEC package</p> <p>materials. Based on the responses of villagers, the total score of each<br>villager was calculated. If the mean score of individuals was more than<br>50% then the villager was marked as having average awareness.<br>Result: Around 72% of individuals lack awareness regarding Aedes<br>mosquito breeding habitats and its role, being the vector agent for<br>dengue fever. Fever was reported by 59% of the study population.<br>Mosquito-repellent coils and mats were used by 33% of respondents.<br>Almost all of them used it during nighttime. Awareness about symptoms<br>of dengue fever improved from 26% of villagers in pre-IEC to 84% of<br>villagers in the post-IEC survey through the chaupal meeting method<br>of IEC as compared to other IEC methods.<br>Conclusion: This study can be an important source of baseline<br>information. Based on the findings of this study, now MCD may focus<br>on IEC campaigning through chaupal meetings with villagers to control<br>the transmission of diseases in villages.</p> <p>How to cite this article:<br>Handa A, Ahir S P, Verma L R. Knowledge, Attitudes,<br>and Practices (KAP) of Rural Communities on<br>Dengue &amp; Evaluating the Most Effective IEC<br>Method for Its Prevention and Control in Delhi.<br>J Commun Dis. 2025;57(1):131-136.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202517</p> Ajay Handa S P Ahir L R Verma Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 131 136 Molecular Characterisation of Enterobacter Species Associated with Community-Acquired Urinary Tract Infection https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/3695 <p>Background: The most typical diseases brought on by Enterobacterales<br>are urinary tract infections (UTIs), which include community-acquired<br>and hospital-associated infections. Numerous such infections are caused<br>by the Enterobacter species, which is a member of ESKAP pathogens<br>known for antibiotic resistance. The current study aims to accurately<br>characterise Enterobacter spp., implicated in community-acquired<br>UTIs, by genetic methods.<br>Patients and Methods: A total of 50 midstream urine specimens were<br>collected from patients with uncomplicated UTIs. Specimen collection<br>was conducted from August to September 2022. The samples were<br>cultured on selective culture media under aerobic conditions for 24<br>hours at 37 °C. The isolates were primarily identified by standard<br>bacteriological methods. The molecular study included bacterial genomic<br>DNA extraction and the use of specific primers for the amplification of<br>465 bp of 16S rRNA gene, and sequencing along with the construction<br>of a phylogenetic tree.<br>Results: Out of 50 urine specimens, only 7 gave positive culture results<br>for Enterobacter spp. (14%), encompasses Enterobacter spp. 4 (57.1%)<br>and Enterobacter cloacae 3 (42.8%). These isolates were confirmed by<br>PCR for 16S rRNA gene and sequencing.<br>Conclusion: This 16S rRNA–based inclusive tree has provided an<br>extremely inclusive tool about the high ability of such genetic fragments<br>to efficiently identify Enterobacter spp. using this genetic fragment.</p> <p>How to cite this article:<br>Ibraheam I A, Bermani O K A L, Banimuslem T A,<br>Alsaadi Z H, Saad A M. Molecular Characterisation<br>of Enterobacter Species Associated with<br>Community-Acquired Urinary Tract Infection. J<br>Commun Dis. 2025;57(1):137-143.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202518</p> Israa Adnan Ibraheam Oruba K. Al-Bermani Thikra Adnan Banimuslem Zainab H. Alsaadi Ali Malik Saad Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 137 143 Social Problem among Hepatitis C and B Virus Patients https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/3578 <p>Introduction: Hepatitis B and C infections pose significant global<br>health burdens, particularly affecting liver health and often remaining<br>asymptomatic, earning them the label “silent killers.” This study aimed<br>to assess the social challenges faced by hseepatitis B and C patients<br>in Baghdad, Iraq.<br>Methods: Conducted from December 2023 to January 2024, the</p> <p>study employed a quantitative, nonexperimental, descriptive cross-<br>sectional design. Purposive sampling was used to select participants</p> <p>from Baghdad Governorate’s Medical City Department/ Digestive<br>and Liver Teaching Hospital. Data were collected through structured<br>questionnaires covering socio-demographics and social parameters.<br>Results: The study revealed that hepatitis patients, predominantly males,<br>face moderate to high levels of loneliness, with a significant impact on<br>their emotional well-being. While they perceive moderate social support,<br>they struggle with feelings of isolation and social disengagement.<br>However, their social relationships with family and community remain<br>moderately intact, similar to healthy individuals.<br>Conclusion: These findings underscore the need for holistic care<br>approaches addressing not only the physical but also the social aspects<br>of hepatitis management to improve patients’ overall well-being and<br>quality of life.</p> <p>How to cite this article:<br>Kadem A Y, Turki S G. Social Problem among<br>Hepatitis C and B Virus Patients. J Commun Dis.<br>2025;57(1):144-150.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202519</p> Ahmed Yaqoub Kadem Salwa Ghazi Turki Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 144 150 Detection of Virulence Genes in Klebsiella pneumoniae and Staphylococcus aureus Isolated from Urinary Catheterised Patients https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4251 <p>Background: One of the most predominant health-related illnesses</p> <p>universally is catheter-associated urinary tract infection (CAUTI). CAU-<br>TIs constitute over 50% of all hospital-acquired infections. Majority of</p> <p>the healthcare-acquired urinary tract infections result from catheter<br>tubes implantation.<br>Objective: To reveal the existence and frequency of the fimH, Ycfm,<br>clfA, and Cap5 genes in two species isolated from patients with urinary<br>catheters.<br>Methods: During the period from November 2023 to February 2024,</p> <p>a total of 50 samples of urine were collected from patients with uri-<br>nary catheters at Tikrit Teaching Hospital and private clinics in Salah</p> <p>Al-Deen province, Iraq. Different antibiotics were used to examine the<br>antibiotics sensitivity test for bacterial isolates.<br>Results: Among the participants, 30 (60%) were female and 20 (40%)<br>were male, with ages ranging between 18 to 80 years and a mean age</p> <p>of 42.06± 14.6 years. Sensitivity for isolates of S. aureus to antibiot-<br>ics was 100% for amoxicillin, 66.6% for trimethoprim, and 44.4% for</p> <p>gentamicin and nitrofurantoin. 11.1% of isolates showed resistance<br>to ciprofloxacin. Among the K. pneumoniae isolates, 66.6 % exhibited</p> <p>resistance to amoxicillin and trimethoprim, while 11.1% showed resis-<br>tance to ciprofloxacin. Molecular analysis was done for 2 isolates of S.</p> <p>aureus and 2 isolates of K. pneumoniae based on their high resistance<br>to antibiotics. The results revealed that the clfA gene was found in<br>100% of S.aureus isolates, while the Cap5 gene was found in 50% of<br>S.aureus isolates. Also, the result unveiled that 100% of K. pneumoniae<br>isolates produced FimH-1 and Ycfm genes.<br>Conclusion: S. aureus and K. pneumoniae are common causes of urinary<br>tract infections in patients with urinary catheters. Virulence genes have<br>an important role in the pathogenicity of S. aureus and K.pneumoniae<br>in patients with urinary catheters.</p> <p>How to cite this article:<br>Khuder H S, Khudhur S S. Detection of<br>Virulence Genes in Klebsiella pneumoniae<br>and Staphylococcus aureus Isolated from<br>Urinary Catheterised Patients. J Commun Dis.<br>2025;57(1):222-230.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202529</p> Huda Saleh khuder Shaimaa Saleh Khudhur Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-04 2025-04-04 57 1 222 230 Association between Vitamin D and Dengue Severity: A Systematic Review and Meta-Analysis Protocol https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4476 <p>Purpose: To understand how vitamin D influences the severity of dengue<br>fever as per WHO 1997 and WHO 2009 classification, as many studies<br>have shown ambiguity in this respect<br>Method: The review has been registered in PROSPERO with registration<br>number CRD420251003676 and will be carried out in accordance with<br>the PRISMA (Preferred Reporting Items for Systematic Reviews and<br>Meta-Analyses) 2020 standards. Peer-reviewed literature will be used<br>to identify the studies. The literature search will be conducted using<br>the following databases: Web of Science, PubMed, PubMed Central,<br>and Scopus. Additionally, the academic search engine - Google Scholar<br>will be searched.; two reviewers independently will screen the titles<br>and abstracts of studies based on predefined eligibility criteria. The<br>other two reviewers will assess the quality based on the Joanna Briggs<br>Institute quality parameters. Heterogeneity among the included studies<br>will be examined using statistical measures such as I2</p> <p>and Cochrane Q<br>statistics. Sensitivity and subgroup analysis will be used to assess the<br>findings’ reliability. If there are more than ten articles, a funnel plot<br>test will be employed to assess publication bias.<br>Conclusion: This systematic review and meta-analysis, in the absence<br>of multi-centric studies, will explore whether Vitamin D deficiency<br>worsens dengue outcomes and if supplementation could help. The<br>findings from this study could help shape future treatments and improve<br>patient care. In areas where dengue is endemic, our systematic review<br>and meta-analysis will assist in pinpointing research gaps and direct<br>future studies and public health initiatives.</p> <p>How to cite this article:<br>Agarwal S J, Jena P K, Kishore J, Sahu L S, Behera<br>C K, Panda S K, Agarwal V. Association between<br>Vitamin D and Dengue Severity: A Systematic<br>Review and Meta-Analysis Protocol. J Commun<br>Dis. 2025;57(1):151-156.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202520</p> Sonam Jalewa Agarwal Pratap Kumar Jena Jugal Kishore Llalli Smruti Sahu Chinmay Kumar Behera Santosh Kumar Panda Vishal Agarwal Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 151 156 Atypical Presentations of Tinea Incognito https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4294 <p>Dermatophytosis is a prevalent superficial fungal infection involving<br>20–25% of the worldwide population, attributed to various species of<br>dermatophytes, such as Trichophyton, Microsporum and Epidermophyton.<br>However, its clinical presentations in immunocompromised individuals<br>or those resorting to topical and systemic corticosteroids often mimic<br>other dermatoses such as exfoliative dermatitis (ED), dermatophytosis<br>incognito, inflammatory, or neoplastic conditions, leading to delayed or<br>mismanagement in treatment. This review focuses on the prevalence of<br>atypical presentations of tinea incognito and their diagnostic evaluations<br>highlighted through relevant case reports from the year 2019 to 2024.</p> <p>How to cite this article:<br>Sindhuja R L, Rajasekaran K, Manickam<br>N, Vellaisamy S G, Gopalan K. Atypical<br>Presentations of Tinea Incognito. J Commun<br>Dis. 2025;57(1):157-166.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202521</p> Ravulapalli Lakshmi Sindhuja Keerthana Rajasekaran Navakumar Manickam Seethalakshmi Ganga Vellaisamy Kannan Gopalan Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 157 166 Current Status of Communicable Diseases – International, National and Kerala Scenarios https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4085 <p>Communicable diseases (CDs) are illnesses caused by certain contagious<br>agents that spread from infected people, animals or contaminated<br>environments to exposed individuals. Transmission can occur directly or<br>indirectly through various methods, including contact, air-borne particles,<br>contaminated objects, or intermediary organisms. CDs are the most<br>important cause of morbidity and mortality around the globe. Infectious<br>diseases, once the leading public health issue in developed nations,<br>have become less prevalent. However, the advent of new infectious<br>diseases poses new threats, while communicable diseases continue to<br>be a major health issue in developing countries. Kerala has experienced<br>an alarming rise in morbidity and mortality due to communicable<br>diseases during the past decade. The state has encountered periodic<br>outbreaks of various infectious diseases, including Nipah, West Nile,<br>and Zika viruses. Additionally, the emergence of Primary Amoebic<br>Meningoencephalitis (PAM) as a public health threat and the endemic<br>status of dengue and leptospirosis in all fourteen districts emphasise<br>the rising challenges in disease control. Communicable disease control<br>requires a multi-faceted approach including vigilant surveillance, rapid<br>detection, and thorough investigation. Promoting good hygiene practices<br>through IEC and BCC, as well as providing prompt treatment, care and<br>support to affected individuals are essential components. This paper<br>offers a thorough examination of communicable diseases worldwide,<br>in India, and specifically in Kerala.</p> <p>How to cite this article:<br>Rajendran R, Anusree S B, Sasi M S, Devi D S, Regu<br>K. Current Status of Communicable Diseases –<br>International, National and Kerala Scenarios. J<br>Commun Dis. 2025;57(1):167-184.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202522</p> R Rajendran S B Anusree M S Sasi D Sheela Devi K Regu Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 167 184 Free-Roaming Dog Versus Stray Dog: Which is better terminology for Rabies control? https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4223 <p>Introduction: Dogs have been an integral part of human life and human<br>settlements. Free-roaming dogs, often lack formal ownership but<br>remain integral to their surroundings. However, inconsistent terms like<br>“stray” or “feral” shape public attitudes, frequently leading to neglect<br>and harmful interventions. This review examines how language plays<br>a role in shaping public health strategies and attitudes toward dogs,<br>focusing on humane rabies control.<br>Methods: Using a narrative review approach, the study examines<br>research articles, policy documents, and legal frameworks like the<br>Prevention of Cruelty to Animals Act (1960), to assess the definitions,<br>cultural attitudes, and rabies prevention strategies for humane<br>management practices.<br>Results: Free-roaming dogs are diverse, ranging from independent<br>feral dogs to community dogs cared for informally. Many remain<br>unvaccinated and unmonitored, perpetuating rabies transmission.<br>Achieving 70% vaccination coverage is critical to breaking this cycle.<br>Success stories from Bhutan and Bali illustrate how humane strategies<br>such as mass vaccination and sterilization outperform harmful practices<br>like culling. Shifting from “stray dog” to “free-roaming dog” encourages<br>compassion, redefines public perceptions, and supports effective<br>management.<br>Conclusion: Aligning societal attitudes with humane legal frameworks<br>fosters safer communities for humans and dogs alike. Adopting<br>compassionate language and strategies promotes coexistence, protects<br>public health, and ensures that free-roaming dogs are treated with<br>dignity and respect. This simple change in terminology inspires a broader<br>cultural shift toward humane treatment and sustainable solutions.</p> <p>How to cite this article:</p> <p>Jena P K, Agarwal S J, Kishore J, Sahu L S. Free-<br>Roaming Dog Versus Stray Dog: Which is better</p> <p>terminology for Rabies control?. J Commun Dis.<br>2025;57(1):185-190.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202523</p> Pratap Kumar Jena Sonam Jalewa Agarwal Jugal Kishore Llalli Smruti Sahu Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 185 190 Helicobacter pylori Eradication Therapies: Current Strategies and Future Perspectives in Peptic Ulcer Disease https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4115 <p>Helicobacter pylori (H. pylori) infection is a significant global health</p> <p>concern, linked to peptic ulcers, gastric adenocarcinoma, and mucosa-<br>associated lymphoid tissue lymphoma. Standard triple therapy with</p> <p>proton pump inhibitors (PPIs) and antibiotics, while effective in many<br>cases, faces rising failure rates due to antibiotic resistance, patient<br>non-compliance, and adverse side effects. Quadruple and sequential<br>therapies have been introduced, utilising additional agents like bismuth<br>and adjusting antibiotic administration. However, these regimens still<br>confront challenges, including drug resistance and high recurrence rates.<br>Probiotics, particularly Lactobacillus strains, have emerged as potential<br>adjuncts to standard therapy, and they have been shown to enhance<br>eradication rates and reduce side effects. Alternative therapies like<br>vonoprazan, a potassium-competitive acid blocker, and personalised<br>dosing based on body size and genetic factors, particularly CYP2C19<br>variations, are under investigation to optimise efficacy. Innovative<br>strategies, such as antibiotic stewardship guided by susceptibility<br>testing, have also been proposed to enhance treatment outcomes<br>while mitigating resistance. Patient education on adherence and proper<br>medication usage has been shown to significantly impact eradication<br>success rates. Additionally, broad eradication programmes aimed at<br>high-risk populations have demonstrated substantial reductions in<br>gastric cancer incidence and mortality, emphasising lifestyle adjustments<br>and early detection. As research advances, future therapies may<br>include antivirulence agents targeting H. pylori’s virulence factors and<br>new mucolytic drugs, promising better outcomes while preserving gut<br>microbiota. Overall, a multifaceted approach incorporating personalised<br>medicine, probiotic adjuncts, and patient-focused strategies appears<br>essential for effectively managing H. pylori infection and minimising<br>associated health risks.<br>How to cite this article:<br>Arun A, Rajesh N, Sreedevi M, Kardar K, Rakesh<br>A, Suresh S, Unnikrishnan V, Nawal A G, Menon L.<br>Helicobacter pylori Eradication Therapies: Current<br>Strategies and Future Perspectives in Peptic Ulcer<br>Disease. J Commun Dis. 2025;57(1):191-196.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202524</p> Akhil Arun Nimsha Rajesh Sreedevi M Khadeeja Kardar Aishwarya Rakesh Sangeetha Suresh Vishnu Unnikrishnan Nawal AG Lakshmi Menon Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 191 196 Possibility of Invasion of Oropouche Virus (OROV) in Asia: A Real-Time Assessment is an Imperative Necessity https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4195 <p>Oropouche orthobunyavirus (OROV), a viral pathogen from the<br>Peribunyaviridae family, is emerging as a public health concern in<br>South and Central America, particularly Brazil and Peru, since its<br>identification in 1955 in South America. The virus is primarily transmitted<br>by the midge Culicoides paraensis, though mosquitoes like Culex<br>quinquefasciatus, Aedes aegypti, and Aedes albopictus might have<br>the potential to play roles as complementary and/ or maintenance<br>vectors. OROV has been reported to have infected more than half<br>a million people to date and causes clinical symptoms viz. fever,<br>headache, joint pain, and rash, similar to those of other endemic<br>mosquito-borne diseases, thus presenting diagnostic dilemmas. The<br>detection of OROV in the saliva and urine of infected individuals further<br>highlights its complex transmission dynamics. The reports of sloths and<br>primates serving as reservoir hosts in South America raise a warning<br>bell regarding its potential adaptability to new hosts viz. rodents and<br>bats if it gets introduced to Asia. Furthermore, the increasing global<br>trade and travel threatens to enhance the possibility of the risk of<br>OROV for cross-continental transmission, which has been clearly<br>evidenced by the recent cases reported amongst travellers returning<br>from South America to Europe and the United States. The diagnostic<br>confusion with other endemic mosquito-borne diseases like dengue and<br>chikungunya, complicates its detection and the ensuing control efforts.<br>The eco-climatic similarities between South America and Southeast<br>Asia strengthen the argument of the possible potential threat of OROV<br>establishing in Asia, especially India, where the suspected vector species<br>of OROV might support its transmission. There is, thus, an imperative<br>need for enhancing surveillance and monitoring, strengthening public<br>health preparedness, and undertaking research to alleviate the emerging<br>threat of OROV in Asia.</p> <p>How to cite this article:<br>Bhattacharya S, Chatterjee P, Tilak R. Possibility<br>of Invasion of Oropouche Virus (OROV) in Asia: A<br>Real-Time Assessment is an Imperative Necessity.<br>J Commun Dis. 2025;57(1):197-202.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202525</p> Sajal Bhattacharya Pallab Chatterjee Rina Tilak Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 197 202 Unravelling the Nexus: A Comparative Analysis of Diabetes Mellitus and Its Impact on Respiratory Infection Susceptibility and Outcomes https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4120 <p>Diabetes mellitus (DM) is a global health crisis that not only affects<br>blood glucose regulation but also significantly impacts various organs<br>and body systems, including immune function. One of the most<br>concerning complications of DM is an increased susceptibility to<br>infections, particularly respiratory infections. These infections, ranging<br>from pneumonia to viral respiratory infections such as influenza and<br>tuberculosis (TB), and fungal infections like aspergillosis, tend to be more<br>severe in diabetic individuals, leading to prolonged illness, increased<br>hospitalisation, and mortality. This article provides a comparative<br>analysis of the mechanisms through which diabetes impacts respiratory<br>infection susceptibility, explores the types of respiratory infections<br>that are most common in diabetic patients and offers an in-depth<br>look at the clinical consequences of these infections. Furthermore, we<br>discuss innovative approaches to managing and preventing respiratory<br>infections in individuals with diabetes, including novel vaccines, precision<br>medicine, and integrated care models.</p> <p>How to cite this article:<br>Thomas R P, Venkatachari K M, Ganamoorth S,<br>Sivaji R K. Unravelling the Nexus: A Comparative<br>Analysis of Diabetes Mellitus and Its Impact on<br>Respiratory Infection Susceptibility and Outcomes<br>J Commun Dis. 2025;57(1):203-212.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202526</p> Rajeev P Thomas Kumudhavalli Manni Venkatachari Sanjay Ganamoorthi Ranjith Kumar Sivaji Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 203 212 A Complex Infectious Case of Dengue Fever with Thrombocytopenia, Acute Hepatitis A, Influenza B, URTI(Upper Respiratory Tract Infection), and Secondary HLH (Hemophagocytic Lymphohistiocytosis): A Diagnostic Challenge https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4168 <p>Worldwide, dengue is the most frequent trigger for viral haemorrhagic<br>fever. Although it is chronic in many tropical nations, instances from<br>non-endemic areas have also been documented on a regular basis in<br>recent years. Nonetheless, the World Health Organization’s revised<br>classification of dengue splits it into three groups: severe dengue,<br>dengue with warning signals, and dengue without warning signs.<br>Significant dengue is defined as those who have a significant vascular<br>leak, hypotension, severe bleeding, or severe organ involvement.<br>Hepatitis, the influenza virus, respiratory infections, liver failure, and<br>Hemophagocytic lymphohistiocytosis (HLH) linked to dengue fever<br>have all been documented; most of these cases involved children, with<br>a small number of adult case reports. Fatal results including a 50%<br>mortality rate have been documented in the child’s research. Here we<br>have presented a case of a 17-year-old teenager with dengue fever and<br>co-morbidities of hepatitis, influenza, lung diseases, and HLH.</p> <p>How to cite this article:<br>Gadhiya H, Radhanpura Y, Parekh K, Trigar P.<br>A Complex Infectious Case of Dengue Fever<br>with Thrombocytopenia, Acute Hepatitis A,<br>Influenza B, URTI(Upper Respiratory Tract<br>Infection), and Secondary HLH (Hemophagocytic<br>Lymphohistiocytosis): A Diagnostic Challenge. J<br>Commun Dis. 2025;57(1):213-216.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202527</p> Harshil Gadhiya Yash Radhanpura Kushal Parekh Pravin Tirgar Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 213 216 Identifying New Common Mosquito Breeding Sites in Flood-Affected Areas of Shahdara South Zone of MCD and Adopted Strategies for Preventing and Controlling Dengue Malaria Cases in the Year 2023 https://medical.advancedresearchpublications.com/index.php/Journal-CommunicableDiseases/article/view/4323 <p>Flooding significantly alters ecosystems, creating new potential habitats<br>for mosquitoes. These changes can increase the risk of vector-borne<br>diseases such as malaria, dengue, and chikungunya. This paper discusses<br>a case study of a Yamuna flood-affected area in Delhi to identify new<br>common mosquito breeding sites and adopted strategies for the<br>prevention and control of vector-borne diseases. We have examined<br>the post-flooding environmental changes, the types of new breeding<br>sites, and proposed methods for the identification and control of these<br>sites to mitigate the associated health risks.</p> <p>How to cite this article:<br>Mishra S, Kohli S. Identifying New Common<br>Mosquito Breeding Sites in Flood-Affected Areas<br>of Shahdara South Zone of MCD and Adopted<br>Strategies for Preventing and Controlling Dengue<br>Malaria Cases in the Year 2023. J Commun Dis.<br>2025;57(1):217-221.</p> <p>DOI: https://doi.org/10.24321/0019.5138.202528</p> Saurabh Mishra Shalini Kohli Copyright (c) 2025 Journal of Communicable Diseases (E-ISSN: 2581-351X & P-ISSN: 0019-5138) https://creativecommons.org/licenses/by-nc/4.0 2025-04-03 2025-04-03 57 1 217 221