Correlation of Serum Leptin with Thyroid Hormones in Metabolic Syndrome Patients with and without Hypothyroidism

Barla Krishna; Priya K Dhas; Veluri Ganesh

Barla Krishna Department of Biochemistry, Vinayaka Mission’s Kirupananda Variyar Medical College and Hospitals, Vinayaka Mission’s Research Foundation (Deemed to the University), Salem, Tamil Nadu, India
Priya K Dhas Associate Professor, Department of Biochemistry, Vinayaka Mission’s Kirupananda Variyar Medical College and Hospitals, Vinayaka Mission’s Research Foundation (Deemed to the University), Salem, Tamil Nadu, India
Veluri Ganesh Assistant Professor, PES University Institute of Medical Sciences and Research, Bangalore, Karnataka, India

Keywords: Hypothyroidism, Leptin, Metabolic Syndrome, ThyroidStimulating Hormone

Abstract

Introduction: Cardiovascular illnesses, type 2 diabetes mellitus, and other metabolic disorders are linked to metabolic syndrome. The purpose of this study was to examine the connection between thyroid hormone profiles and blood leptin levels in individuals with metabolic syndrome who did not have hypothyroidism.
Methods: A total of 120 participants were included 80 patients with metabolic syndrome (40 with hypothyroidism and 40 without hypothyroidism) and 40 healthy controls. Blood glucose levels, lipid profiles, thyroid hormone levels, and serum leptin concentrations were measured and compared across groups.
Results: Serum leptin levels were significantly higher in metabolic syndrome patients with hypothyroidism (25.18 ± 5.46) compared to those without hypothyroidism (11.55 ± 3.15) and healthy controls (4.05 ± 2.12) (p- 0.0001). A significant positive correlation was observed between serum leptin and thyroid-stimulating hormone (TSH) levels (r = 0.749, p- 0.0001).
Conclusion: These results imply that in patients with metabolic syndrome, leptin metabolism and the pituitary-thyroid axis are strongly correlated. Serum leptin level monitoring may help identify and stop problems in
these patients early.

How to cite this article:
Krishna B, Dhas P K, Ganesh V. Correlation
of Serum Leptin with Thyroid Hormones in
Metabolic Syndrome Patients with and without
Hypothyroidism. Chettinad Health City Med J.
2025;14(1):19-24.

DOI: https://doi.org/10.24321/2278.2044.202504

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