Intranasal Drug Delivery System: An Innovative Approach

Abstract

Drug delivery through the nose has been used for thousands of years. For medications like protein and peptides that have low oral bioavailability and are active at the microgram level, this is a helpful delivery system. The nasal mucosa’s enormous surface area allows for a quick start of a therapeutic impact. The Ayurvedic medical system has acknowledged the possibility of an intranasal therapy that transports drugs avoiding the hepatic metabolic process and going straight to the central nerve system (CNS). The medications are inhaled through the nose for a localised or systemic effect. They are readily available and appropriate for self-medication. The nasal mucosa’s enormous surface area allows for a direct distribution of therapeutic effects to the CNS with a quick commencement of action. The nasal drug delivery will be helpful for drugs that are unstable when taken orally due to considerable deterioration within the digestive system. Instead of parenteral therapy, the nasal route is beneficial for long-term treatment. Because the nasal mucosa is extremely permeable and vascularised, it can also be utilised for systemic therapy, as the medication enters the bloodstream
immediately. They all work to increase patient comfort, convenience, and compliance.