Formulation, Development and Evaluation of Topical Emulgel of Luliconazole Using Essential Oils
Abstract
Introduction: Luliconazole, an antifungal agent, is characterized by low solubility and high permeability. The study was conducted to develop emulgel formulations of luliconazole using essential oils as penetration enhancers and to compare their properties with those of plain luliconazole emulgel.
Methods: Emulgels were prepared by incorporating luliconazole emulsions into a Carbopol 940 gel base. Penetration enhancers such as clove oil and tea tree oil were used at various concentrations. The formulations were evaluated for their physical properties, in vitro drug release, ex vivo permeation, antifungal activity, and stability.
Results: The evaluation revealed that the luliconazole emulgel containing clove oil demonstrated superior in vitro drug release, ex vivo permeation, antifungal activity, and skin permeability compared to the plain luliconazole emulgel and the formulation containing tea tree oil.
Conclusion: The combination of luliconazole with clove oil in the emulgel formulation enhances skin permeability and potentiates antifungal activity, making it a promising approach for improving luliconazole’s
therapeutic efficacy.
How to cite this article:
Wani S K, Katti S A, Pawar S H, Tayde M A, Patil R
A. Formulation, Development and Evaluation of
Topical Emulgel of Luliconazole Using Essential
Oils. Chettinad Health City Med J. 2025;14(1):35-
41.
DOI: https://doi.org/10.24321/2278.2044.202506
References
Sreevidya V. S. An overview on emulgel Int Pharm Phytopharmacol Res. 2019;9(1):92-7
Sharadha M, Gowda DV, Vishal Gupta N, Akhila A-R. An overview on topical drug delivery system-updated
review, Int J Res Pharm Sci 2020;11(1):368-85.
Kumar M,Shanthi N, Mahato AK. Qualitative and quantitative methods for determination of drug luliconazole. Int J Res Advent Technol. 2018;6(10):2764-70. [Google Scholar]
Yadav S, Waikar S, Invally M, Ranade S. Topical emulgel of tolnaftate with penetration enhancer: development,
characterisation and antifungal activity. Indian J Med Res Pharm Sci. 2017;4(10):28-35. [Google Scholar]
