Design Expert Software Empowering Ocular Drug Delivery: Learning From Past Successes With Ocular Inserts
Abstract
The primary objective of this review is to explore the techniques adopted that can slow down the excretion of drugs from the ocular surface and prolong the contact time of the medication with the target tissues. Ocular inserts have emerged as a promising approach in this regard and can be broadly categorised into three types: soluble, insoluble, and biodegradable ocular inserts. In the field of ophthalmic formulations, conventional dosage forms are widely used, accounting for approximately 90% of the products available in the market. However, one of the main challenges faced with conventional formulations is the rapid loss of medication from the cornea, leading to reduced bioavailability and efficacy of ocular medications. To overcome this challenge and improve the delivery of ocular medications, significant efforts have been focused on the development of novel drug delivery systems specifically designed for ophthalmic administration. Recent studies in this area have explored the combination of different drug delivery technologies to achieve enhanced therapeutic outcomes. Overall, the development of ocular inserts represents a significant advancement in the treatment of various eye diseases. These inserts offer the potential to improve drug bioavailability, prolong therapeutic effects, and enhance patient compliance by reducing the frequency of administration. The work summarises that further research and development efforts are needed in this field to refine these technologies and optimise their effectiveness in ocular drug delivery.
How to cite this article:
Repollu M, Chinthaginjala H. Design Expert Software Empowering Ocular Drug Delivery: Learning From Past Successes With Ocular Inserts. Chettinad Health City Med J. 2024;13(2):81-91.
DOI: https://doi.org/10.24321/2278.2044.202433
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