A Prospective Observational Study on Assessment of Antibiotic Therapy in Renal Failure Patients with Infections

  • Pradeep Battula Department of Pharmacy Practice, Santhiram College of Pharmacy, Nandyal, Andhra Pradesh, India.
  • Somala Savithri Department of Pharmacy Practice, Santhiram College of Pharmacy, Nandyal, Andhra Pradesh, India.
  • Kamini Poojitha Department of Pharmacy Practice, Santhiram College of Pharmacy, Nandyal, Andhra Pradesh, India.
  • Y Saivani Department of Nephrology, Santhiram Medical College and General Hospital, Nandyal, Andhra Pradesh, India.
Keywords: Acute Renal Failure, Antibiotics, Chronic Kidney Disease, Culture Sensitivity, Renal Failure


Introduction: The combination of renal failure and infections is the primary cause of death. Effective drug treatment is crucial for managing these conditions and reducing illness and death risks.
Aim: The study aims to identify the type of microorganism causing kidney or renal infection, its sensitivity patterns and to assess the type of antibiotic prescribed in renal failure patients with infections.
Methods and Material: The study was conducted at Santhiram Medical College and General Hospital in Nandyal between November 2021 and April 2022. The study aimed to analyse the cases of 130 patients diagnosed with renal failure diseases and accompanying infections in the nephrology department. The study prospectively collected demographic data, diagnosis information, prescribing patterns, and culture sensitivity reports.
Results: In this study, males exhibited a higher likelihood of developing renal failure diseases, with an incidence rate of 65%, compared to females, who showed an incidence rate of 45%. Individuals who were 61–70 years old, regardless of gender, were at a heightened risk of developing renal failure diseases. The study also revealed the presence of 8 distinct microorganisms, with E. coli being the most prevalent cause of infection, contributing to 34.61% of cases.
Conclusions: Our research determined that infections in patients with renal failure are primarily caused by E. coli and Klebsiella microorganisms. Treatment typically involves prescribing antibiotics, with cefoperazone and sulbactam being commonly used. However, it was observed that doxycycline and levofloxacin are ineffective against all microorganisms. By analysing the total white blood cell count, it has been determined that cefoperazone-sulbactam is a more effective antibiotic for reducing infections.

How to cite this article:
Battula P, Savithri S, Poojitha K, Saivani Y. A Prospective Observational Study on Assessment of Antibiotic Therapy in Renal Failure Patients with Infections. Chettinad Health City Med J. 2024;13(1):4-12.

DOI: https://doi.org/10.24321/2278.2044.202402


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