Assessment of Chromosomal Aneuploidy in PGT-A Embryos

  • G Shiva Krishna Senior Embryologist, Laxmi Narasimha Hospital, Warangal, India.
  • Sanjeev Krishna Gupta Professor, OPJS University, Rajasthan, India.
Keywords: PGT-A, Embryo Biopsy, Aneuploidy, Mosaicism


Introduction: Preimplantation genetic testing is a procedure to evaluate genetically normal embryos and take them for embryo transfer. It helps in identifying chromosomal aneuploidies, mosaicism, and euploid embryos.
Aim: To assess chromosomal aneuploidy through PGT-A in IVF embryos.

Methods: A retrospective study was done from January 2021 to June 2022. 55 blastocysts were assessed for PGT-A through Comparative Genomic Hybridisation (CGH).

Results: Among the 55 blastocysts included in the study, 19 embryos showed euploidy and 7 embryos showed multiple aneuploidies. Autosomes were normal but sex chromosomes were abnormal in 3 embryos. Multiple mosaic gain/ loss was reported in 4 embryos. Sex chromosomes abnormality was seen in 8 embryos.

Conclusion: 19 embryos showed euploidy. More than half of the embryos showed aneuploidy. Mosaicism seems to be a more common phenomenon in IVF embryos as compared to other kinds of aneuploidy like syndromes, triploidy, monosomy, and other genetic abnormalities. Sex chromosome abnormality was reported in 8 embryos.

How to cite this article:
Krishna GS, Gupta SK. Assessment of Chromosomal Aneuploidy in PGT-A Embryos. Chettinad Health City Med J. 2023;12(2):28-32.




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