Study of Compliance, Pattern of Treatment Interruption and Adverse Events Reported by Anaemic Pregnant Women Receiving the Parenteral Iron Sucrose Therapy
Abstract
Background: In spite of many efforts by the government since independence anaemia in pregnant women has shown resistance to improvement.
Aim: The main aim was to study the compliance of parenteral iron sucrose therapy in pregnant woman along with an additional objective which was to study the pattern of treatment interruption and adverse
events observed by them.
Methods: This study was conducted by the Department of Community Medicine in the rural and urban field practice area of district Nuh. A list of three hundred and eighty four anaemic pregnant females put
on IVIS therapy, fetched from the health centre and relevant details were documented.
Result: Out of total of 384 study participants, 291 (75.8%) were compliant with IVIS therapy i.e., they received all four doses. Out of total 93 either non-compliant or partially compliant subjects, most of them (51.6%, n=48) missed 3 doses whereas 22 participants (23.7%) missed 2 doses of the IVIS therapy. Ten study participants (10.7%) showed non-compliance to the therapy. Multigravida subjects were either non or partial compliant compared to primigravida. The three most common adverse events recorded at the time of infusion of 1st dose
of IVIS therapy were swelling at injection site, pruritus, and muscle pain or joint pain experienced by 32 (8.3%), 17 (4.4%) and 16 (4.2%) study participants respectively.
Conclusion: IVIS therapy is relatively safe therapy and well tolerated by anaemic pregnant females when given as slow infusion. Multigravida subjects were either non or partial compliant compared to primigravida
females for IVIS therapy.
How to cite this article:
Singh A, Agrawal D, Goel PK. Study of Compliance, Pattern of Treatment Interruption and Adverse Events Reported by Anaemic Pregnant Women Receiving the Parenteral Iron Sucrose Therapy. Chettinad Health City Med J. 2022;11(3):43-47.
DOI: https://doi.org/10.24321/2278.2044.202228
References
International Institute of Population Sciences (IIPS) National Family Health Survey (NFHS) 5 Fact Sheets
[Accessed on May 21, 2021]. Available from: http://rchiips.org/nfhs/factsheet_NFHS-5.shtml.
Singal N, Setia G, Taneja BK, Singal KK. Factors associated with maternal anaemia among pregnant
women in rural India. BJMS. 2018 Sep;17(4):583-92. [Google Scholar]
Vindhya J, Nath A, Murthy GV, Metgud C, Sheeba B, Shubhashree V, Srinivas P. Prevalence and risk factors of
anemia among pregnant women attending a public- sector hospital in Bangalore, South India. J Family Med Prim
Care. 2019 Jan;8(1):37-43. [PubMed] [Google Scholar]
Rahman MA, Khan MN, Rahman MM. Maternal anaemia and risk of adverse obstetric and neonatal
outcomes in South Asian countries: a systematic review and meta-analysis. Public Health Pract (Oxf). 2020
Jun;1:100021. [PubMed] [Google Scholar]
Jogia AD, Kanabar BR, Rathod JB. A prospective study of adverse effects and compliance of intravenous iron
sucrose for the treatment of severe anemia in ante-and post-natal women. Int J Med Sci Public Health. 2017
Mar;6(3):489-92. [Google Scholar]
Devasenapathy N, Singh R, Moodbidri P, Bhushan H, Gupta S, Zodpey SP, Neogi SB. An observational
study on the use of IV iron sucrose among anaemic pregnant women in government healthcare facilities
from two states of India. J Obstet Gynaecol India. 2015 Jul;65(4):230-5. [PubMed] [Google Scholar]
Uma G, Kumkum S, Aditi D, Ayesha A, Kumar GN. Efficacy and safety of intravenous iron sucrose for
treating anemia in pregnancy: a pilot study. J Evol Med Dent Sci. 2013 Jul;2(27):5007-13. [Google Scholar]
Neeru S, Nair NS, Rai L. Iron sucrose versus oral iron therapy in pregnancy anemia. Indian J Community
Med. 2012 Oct;37(4):214-8. [PubMed] [Google Scholar]
Reveiz L, Gyte GM, Cuervo LG, Casasbuenas A.Treatments for iron-deficiency anaemia in pregnancy.
Cochrane Database Syst Rev. 2007;2:CD003094. [PubMed] [Google Scholar]
Perewusnyk G, Huch R, Huch A, Breymann C. Parenteral iron therapy in obstetrics: 8 years experience with
iron-sucrose complex. Br J Nutr. 2002 Jul;88:3-10. [PubMed] [Google Scholar]
Das SN, Devi A, Mohanta BB, Choudhury A, Swain A, Thatoi PK. Oral versus intravenous iron therapy in iron
deficiency anaemia: An observational study. J Family Med Prim Care. 2020 Jul;9(7):3619-22. [PubMed]
[Google Scholar]
