A Preliminary Study on Parenteral Intravenous Iron Sucrose (IVIS) Therapy in Managing Anaemia among Pregnant Women in Primary Care Setting of Rural Haryana
Background: Intravenous iron sucrose (IVIS) therapy is a newly introduced service component for combating moderate anaemia in pregnant women by the Haryana state as a public health measure from the year 2014.
Aim: The aim of this study was to ascertain the effect of IVIS therapy on pregnant females having anaemia who were receiving this therapy in a primary care setting.
Method: This prospective study was conducted at a randomly selected rural Primary Health Centre (PHC) in the Nuh district. 138 moderately anaemic females were given the standard form of IVIS therapy. The study subjects were requested to repeat haemoglobin levels after 2 weeks and 4 weeks of receipt of the last dose of therapy.
Results: Of the total 154 anaemic pregnant women, 138 (89.6%) were diagnosed to have moderate anaemia. The number of study subjects with moderate anaemia reduced from 138 to 54, (54.54% reduction) when haemoglobin level was measured at the end of 4 weeks (endline). The mean rise in haemoglobin level among moderately anaemic pregnant females was 1.62 g/dL. At the end of 4 weeks (endline), 73.75% of the study subjects achieved normal levels of haemoglobin (from a total of 80 moderately anaemic women measurement).
Conclusion: The mean rise in haemoglobin level in moderately anaemic pregnant females was 1.62 g/dL among participants who received IVIS therapy in a primary care setting in an underprivileged area in Haryana state. The women having severe anaemia achieved a better rise in Hb levels.
How to cite this article:
Singh A, Agrawal D, Goel PK. A Preliminary Study on Parenteral Intravenous Iron Sucrose (IVIS) Therapy in Managing Anaemia among Pregnant Women in Primary Care Setting of Rural Haryana. Chettinad Health City Med J. 2022;11(2):9-14.
International Institute of Population Sciences (IIPS) [Internet]. National Family Health Survey (NFHS) 5 Fact Sheets; [cited 2021 May 21]. Available from: http://rchiips.org/nfhs/factsheet_NFHS-5.shtml
Kozuki N, Lee AC, Katz J; Child Health Epidemiology Reference Group. Moderate to severe, but not mild, maternal anaemia is associated with increased risk of small-for-gestational-age outcomes. J Nutr. 2012;142:358-62. [PubMed] [Google Scholar]
Shankar B, Agrawal S, Beaudreault AR, Avula L, Martorell R, Osendarp S, Prabhakaran D, Mclean MS. Dietary and nutritional change in India: implications for strategies, policies, and interventions. Ann N Y Acad Sci. 2017;1395(1):49-59. [PubMed] [Google Scholar]
Das SN, Devi A, Mohanta BB, Choudhury A, Swain A, Thatoi PK. Oral versus intravenous iron therapy in iron deficiency anaemia: an observational study. J Family Med Prim Care. 2020 Jul;9(7):3619. [PubMed] [Google Scholar]
International Institute for Population Science [Internet]. National Family Health Survey 2015-16: State fact sheet Haryana. Mumbai: Ministry of Health and Family Welfare, Government of India; 2016 [cited 2022 May 19]. Available from: http://rchiips.org/nfhs/pdf/NFHS4/HR_FactSheet.pdf
National Health Portal of India [Internet]. Anemia during pregnancy; [cited 2022 Jan 7]. Available from: https://www.nhp.gov.in/disease/gynaecology-and-obstetrics/anaemia-during-pregnancy-maternal-anemia
Haldar P, Kant S, Yadav V, Majhi J, Malhotra S, Kaur R, Kumar R, Singh AK, Archana S, Lohia A, Rath R, Ahamed F. Effect of intravenous iron sucrose on hemoglobin level, when administered in a standard-dose, to anemic pregnant women in rural Northern India. J Family Med Prim Care. 2018;7:762-8. [PubMed] [Google Scholar]
Gupta A, Rathore AM, Manaktala U, Gupta A, Gupta S. Role of intravenous iron sucrose in correction of anemia in antenatal women with advanced pregnancy. Indian J Hematol Blood Transfus. 2015 Jun;31(2):251-4. [PubMed] [Google Scholar]
Shrivastava D, Inamdar S, Bhute S, Singh A. Effectiveness of intravenous iron sucrose in management of irondeficient anemia of pregnancy at rural hospital set up. J Obstet Gynecol India. 2012 Apr;62(2):154-7. [PubMed] [Google Scholar]
Gutteridge J. Iron and free radicals. In: Hallberg L,Asp NG, editors. Iron nutrition in health and disease. London: John Libbey & Comp; 1996. p. 239‐46.
Jian J, Yang Q, Dai J, Eckard J, Axelrod D, Smith J, Huang X. Effects of iron deficiency and iron overload on angiogenesis and oxidative stress-a potential dual role for iron in breast cancer. Free Radic Biol Med. 2011 Apr 1;50(7):841-7. [PubMed] [Google Scholar]
Hamoudi A, Taqi V. Iron overload cardiomyopathy due to non-classical hereditary hemochromatosis. J Med Cases. 2019 Feb 1;10(2):58-61. [Google Scholar]
Zhang H, Zhabyeyev P, Wang S, Oudit GY. Role of iron metabolism in heart failure: from iron deficiency to iron overload. Biochim Biophys Acta Mol Basis Dis. 2019 Jul 1;1865(7):1925-37. [PubMed] [Google Scholar]
Ministry of Health and Family Welfare Statistics Division [Internet]. Rural Health Statistics; 2018-19 [cited 2021 May 23]. Available from: https://main.mohfw.gov.in/sites/default/files/Final%20RHS%202018-19_0.pdf
Tabrizi FM, Barjasteh S. Maternal hemoglobin levels during pregnancy and their association with birth weight of neonates. Iran J Ped Hematol Oncol. 2015;5(4):211-7. [PubMed] [Google Scholar]
Kalaivani K. Prevalence & consequences of anaemia in pregnancy. Indian J Med Res. 2009;130(5):627-33. [PubMed] [Google Scholar]
International Institute for Population Science [Internet]. National Family Health Survey 2015-16: District fact sheet Mewat. Mumbai: Ministry of Health and Family Welfare, Government of India; 2016; [cited 2022 Jan 12]. Available from: http://rchiips.org/nfhs/FCTS/HR/HR_FactSheet_87_Mewat.pdf