Failure of Rabies Post-exposure Prophylaxis Despite Achieving Adequate Antibody Titers in a Goat at Veterinary Hospital Rehan, District Kangra, Himachal Pradesh, India

  • Omesh Kumar Bharti Faculty, Epidemiologist-cum-State Master Trainer on Intra-dermal Rabies Vaccination-cum-incharge, State Intra-dermal Antirabies Clinic and Research Centre, DDU Hospital, Shimla, Himachal Pradesh, India.
  • Anju Vyas Senior Veterinary Officer-cum-Doctor-incharge, Rehan Veterinary Hospital, Nurpur, District Kangra, Himachal Pradesh, India.
  • Uppinder Kumar Sharma Assistant Director-cum-Senior Veterinary Health Officer, Sub-divisional Hospital, Jawali, Kangra, Himachal Pradesh, India.
  • Manvi Sharma Rajendra Prasad Government Medical College, Tanda, Himachal Pradesh, India.
Keywords: Rabies, Post-exposure Prophylaxis Failure, Intramuscular Vaccination, Intradermal


Post-Exposure Prophylaxis (PEP) failures in cattle/ animals have been reported from all parts of the globe. Here, we report a failure of PEP in a goat despite achieving high titres after PEP. This PEP failure may be attributable to the fact that we may have missed some abrasions that were not infiltrated with Rabies equine Immunoglobulins (eRIG) or there may have been direct binding of rabies viruses to the nerve endings. Also, a delay in initiating PEP may be the reason as the goat was presented for PEP after 12-14 hours of bite by a rabid dog. Still, we need to search for the answers as all animals having antibody titers more than the arbitrary protection limit of 0.5 IU/ml survived except the goat despite having very high RVNA titers of 7.5 IU/ml at day 14.

How to cite this article:
Bharti OK, Vyas A, Sharma UK, Sharma M. Failure of Rabies Post-exposure Prophylaxis Despite Achieving Adequate Antibody Titers in a Goat at Veterinary Hospital Rehan, District Kangra, Himachal Pradesh, India. APCRI J. 2023;25(1):28-30.



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