Isoniazid induced Gynaecomastia

Ramakant Dixit; Kamender  Singh Pawar

Ramakant Dixit Professor & Unit Head, Department of Respiratory Medicine, J. L. N. Medical College, Ajmer
Kamender Singh Pawar Former Resident, Department of Respiratory Medicine, J. L. N. Medical College, Ajmer

Keywords: Gynaecomastia, Isoniazid.

Abstract

Abstract:
Gynaecomastia is very uncommon due to anti tuberculosis drugs. We describe this event in a 48-year-old male patient who received antituberculosis chemotherapy with isoniazid, rifampicin, ethanmbutol and pyrazinamide for right sided pleural effusion. After three months of treatment, he developed painful bilateral gynaecomastia. Gynaecomastia disappeared completely after stopping the isoniazid. Various mechanisms leading to gynaecomastia are also briefly discussed.