A Case Report: Forced Alkaline Diuresis in a Case of 2, 4 D Dimethyl-Amine Herbicide Poisoning

Sagar Gupta; Ranjana Deshmukh; Sudhir Deshpande; Shriram Patki; Sumit Akotkar; Pravin  Suradkar

Sagar Gupta Physician, Intensivist, HOD, Emergency Care Medicine, Dr Hedgewar Hospital, Sambhajinagar, Maharashtra, India
Ranjana Deshmukh HOD, Department of Medicine, Dr Hedgewar Hospital, Sambhajinagar, Maharashtra, India
Sudhir Deshpande Chief Intensivist, Dr Hedgewar Hospital, Sambhajinagar, Maharashtra, India
Shriram Patki Intensivist, Dr Hedgewar Hospital, Sambhajinagar, Maharashtra, India
Sumit Akotkar DNB Resident, Dr Hedgewar Hospital, Sambhajinagar, Maharashtra, India
Pravin Suradkar Research Medical Officer, Dr Hedgewar Hospital, Sambhajinagar, Maharashtra, India

Keywords: 2, 4 d Dimethylamine, Weedcide intoxication, No Antidote, Forced alkaline diuresis-Life saving.

Abstract

To study the use of 2, 4 D is increasing because of resistance emerging
in Paraquat and Glycophosphate for weed control, hence accidental
or suicidal intoxication incidences are rising. Action of this is dose
dependent with detrimental effects on cell membrane of Acetyl - CoA
metabolism and oxidative phosphorylation.
It is fatal if not treated timely, having no specific antidote involving
CNS, CVS, RS, Hepatoblliary, muscle and endocrine systems. Usually,
it is very common with intoxication of organophospate compounds in
India, similar to alcohol, sedative drugs, aromatic compounds which is
suspected when patient comes to emergency room. So, Identification
of correct compound for timely management can be lifesaving.
Prolonged Coma, Metabolic complications, Skeletal muscle complication
are some of the complications of 2 4 D. Treatment with forced alkaline
diuresis is life saving measure in resource limited rural area where
hemodialysis is not available.

How to cite this article:
Gupta S, Deshmukh R, Deshpande S, Patki S,
Akotkar S, Suradkar P. A Case Report : Forced
Alkaline Diuresis in a Case of 2, 4 D Dimethyl
Amine Herbicide poisoning. J Adv Res Med 2025;
12(1): 1-3.

DOI: https://doi.org/10.24321/2349.7181.202501

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