Early Diagnosis for Chronic Kidney Disease and its Associated Risk Factors among Adults in a Rural Population of Delhi: A Cross-Sectional Study
Abstract
Background: Chronic kidney disease (CKD) is emerging public health problem worldwide including India. It’s diagnosis at 5th stage complicates treatment leading to end-stage renal disease (ESRD). The early interventions, life style modification and management may help to slow its progress.
Methods: A total of 859 participants were screened in OPD of Rural Health Training Center Najafgarh rural area of Delhi in 2018 after getting written informed consent from the participants. The data was recorded through a pre-structured questionnaire containing their personal and medical history. Blood sugar, urea, serum creatinine and serum albumin were examined. Other anthropometric parameters like blood pressure (BP) and height weight were also measured for the body mass index (BMI). Data was analyzed with the help of SPSS ver 16. CKD versus Non-CKD participants were compared for any significant difference and chi square test was.
Result: The mean age of participants was 39.72±SD 16.85 (range 18-90 years). More participants were males (61%), literate (81.8%) and unemployed (68.8%). 21.9%, 24.8% and 5.7% had previous history of BP, diabetes and any kidney problems. The overall prevalence of CKD was 8.7%; mean eGFR was 91.67 ± 24.20 in CKD versus 96.44±19.95 in non-CKD group. Prevalence of CKD stages 1, 2, 3a, 3b, 4 and 5 were 56%, 35%, 6.05%, 1.08%, 0.93% and 0.46% respectively. Hypertensive and diabetic were significantly associated with CKD.
Conclusion: The prevalence of CKD was 8.7% and 6.0% had stage 3a or worse. Diabetic and hypertensive patients should be screened for kidney diseases as early intervention may retard the progression of kidney disease.
How to cite this article:
Tripathi N, Kishore J, Kumar N, Bhatnagar A, Kumar R, Verm H. Early Diagnosis for Chronic Kidney Disease and its Associated Risk Factors among Adults in a Rural Population of Delhi: A Cross-Sectional Study. J Adv Res Med 2019; 6(4): 20-26.
DOI: https://doi.org/10.24321/2349.7181.201921
References
Eckardt KU, Coresh J, Devuyst O, Johnson RJ, Köttgen A, Levey AS et al. Evolving importance of kidney disease:
from subspecialty to global health burden. Lancet 2013; 382(9887): 158-169. [PubMed].
Venktapathy R, Govindarajan V, Oza N, Parameswaran S, Dhanasekaran BP, Prashad KV et al. Salivary creatinine estimation as an alternative to serum creatinine in chronic kidney disease patients. IJN 2014; Article ID
, 6.
Abdulla HI, Al-Kotany MY, Mahdi KA. Assessment of oral manifestations of patients with renal failure undergoing hemodialysis by serum and salivary biomarkers. MDJ 2012; 9(1): 118-129.
Modi GK, Jha V. The incidence of end-stage renal disease in India: a population-based study. Kidney Int
; 70(12): 2131-2133.
Kher V. End-stage renal disease in developing countries. Kidney Int 2002; 62(1): 350-362.
Jha V. End-stage renal care in developing countries: the India experience. Ren Fail 2004; 26(3): 201-208.
Sakhuja V, Sud K. End-stage renal disease in India and Pakistan: burden of disease and management issues.
Kidney Int Suppl 2003; 83(83): S115-8.
Bello AK, Nwankwo E, El Nahas AM. Prevention of chronic kidney disease: a global challenge. Kidney
International 2005; S11-17.
Nugent R A, Fathima SF, Feigl AB, Chyung D. The burden of chronic kidney disease on developing nations: a 21st century challenge in global health. Nephron. Clinical Practice 2011; 118: c269-77.
Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V et al. Global and regional mortality from 235
causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease
Study 2010. Lancet 2012; 380(9859): 2095-2128.
USRDS. Atlas of end-stage renal disease Bethesda: National Institutes of Health, National Institute of
Diabetes and Digestive and Kidney Diseases. 2013. Cited in January 7 2013.
Rajapurkar MM, John GT, Kirpalani AL, Abraham G, Agarwal SK, Almeida AF et al. What do we know about
chronic kidney disease in India: First report of the Indian CKD registry? BMC Nephrol 2012; 13: 10.
Narula AS. Chronic kidney disease. The looming threat. MJAFI 2008; 64(1): 2, 3.
Singh AK, Farag Youssef MK, Rajapurkar Mohan M. Epidemiology and risk factors of chronic kidney disease
in India - results from the SEEK (Screening and Early Evaluation of Kidney Disease) study. BMC Nephrology
; 14: 114.
Kishore J, Mondal AK, Chandra L et al. Validation of Mobile lab “Field and laboratory-based validation
of mobile lab (Suitcase & Labike model) against gold standard methodsâ€. Advance Research Publications,
Ghaziabad. 2018.
Hao-Hua D, Guo-Lin H, Feng-Lin L, Liu AL, Xia XH, Chen W. Colorimetric detection of urea, urease, and urease
inhibitor based on the peroxidase-like activity of gold nanoparticles. Analytica Chimica Acta 2016; 915: 74-80.
Jaffe M. Uber den niederschlag, welchenpikrinsaure in normalenhrnerzeugt und ubere ineneue reaction des
kreatinins. Z Physiol Chem 1886; 10: 391-400.
Trinder P. Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic
chromogen. J Clin Pathol 1969; 22(2): 158-161.
Young DS. Effects of drugs on clinical laboratory tests for albumin. 4th ed. AACC Press, Washington, DC. 1995,
-22.
Levey AS, Coresh J, Greene T, Marsh J, Stevens LA, Kusek JW et al. Expressing the modification of diet in
renal disease study equation for estimating glomerular filtration rate with standardized serum creatinine
values. Clin Chem 2007; 53(4): 766-772.
Misra A, Vikram NK, Gupta R, Pandey RM, Wasir JS, Gupta VP. Waist circumference cut off points and action
levels for Asian Indians for identification of abdominal obesity. International Journal of Obesity 2006; 30(1):
-111.
Mancia G, Sega R, Bravi C, Vito GD, Valagussa F, Cesana G et al. Ambulatory blood pressure normality: results
from the PAMELA study. J Hypertens 1995; 13: 1377-1390.
Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the joint national committee on prevention,
detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA 2003; 289(19):
–72.
Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the expert committee
on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003; 26(Suppl 1): S5-20.
Vassalotti JA, Stevens LA, Levey AS. Testing for chronic kidney disease: a position statement from the national
kidney foundation. Am J Kidney Dis 2007; 50(2): 169-180.
Anand S, Shivashankar R, Ali MK, Kondal D, Binukumar B, Montez-Rath ME et al. Prevalence of chronic kidney
disease in two major Indian cities and projections for associated cardiovascular disease. Kidney Int 2015;
(1): 178-185.27. Varma PP. Prevalence of chronic kidney disease in India - Where are we heading? Indian J Nephrol 2015; 25(3): 133-135.
Shan Y, Zhang Q, Liu Z, Hu X, Liu D. Prevalence and risk factors associated with chronic kidney disease in
adults over 40 years: a population study from Central China. Nephrology (Carlton, Vic.) 2010; 15: 354-361.
Chen W. Liu Q, Wang H, et al. Prevalence and risk factors of chronic kidney disease: a population study
in the Tibetan population. Nephrology, dialysis, transplantation: official publication of the European
Dialysis and Transplant Association - European Renal Association 2011; 26: 1592-1599.
Agarwal SK, Dash SC, Irshad M, Raju S, Singh R, Pandey RM. Prevalence of chronic renal failure in adults in
Delhi, India. Nephrol Dial Transplant 2005; 20(8): 1638-1642.
Chen J. Epidemiology of hypertension and chronic kidney disease in China. Current Opinion in Nephrology
and Hypertension 2010; 19: 278-282.
Qin X, Wang Y, Li Y, Xie D, Tang G, Wang B et al. Risk factors for renal function decline in adults with normal
kidney function: a 7-year cohort study. Journal of Epidemiology and Community Health 2015; 69: 782-
Levey AS, Bilous R, Shlipak MG. CKD and diabetes: what can we learn from their similarities and differences?
American Journal of Kidney Diseases: The Official Journal of the National Kidney Foundation 2016; 67:
-363.
Prasad DS, Kabir Z, Dash AK, Das BC. Prevalence and risk factors for diabetes and impaired glucose tolerance in Asian Indians: a community survey from urban Eastern India. Diabetes Metab Syndr 2012; 6(2): 96-101.
Devi P, Rao M, Sigamani A, Faruqui A, Jose M, Gupta R et al. Prevalence, risk factors and awareness of
hypertension in India: a systematic review. J Hum Hypertens 2013; 27(5): 281-287.
