Cerebral Stroke in Celphos Poisoning: A Rare Case Report

  • Satish Kumar
  • Harish Gupta Associate Professor, Department of Medicine, King George’s Medical University, Lucknow, UP, India
  • Virendra Atam Professor and Head, Department of Medicine, King George’s Medical University, Lucknow, UP, India
Keywords: Celphos, Aluminium Phosphide, Suicidal Attempts, Ischaemic Stroke

Abstract

Acute aluminium phosphide poisoning is fatal. Till date no specific antidote has been found for it, as a consequence mortality, is extremely high. Celphos is aluminium phosphide (AlP), a solid chemical compound of fumigant nature. This compound is used as an agricultural pesticide and has been seen to be taken orally in suicidal cases. Neurological presentation is very common in celphos poisoning while the occurrence of cerebrovascular ischaemia is rare. Here, we have reported a case of ischaemic stroke as an initial manifestation of celphos poisoning on the third day of ingestion. Angiography conducted on the right middle cerebral artery revealed evidence of in-situ thrombosis. All other aetiologies of young ischaemic stroke were excluded.

How to cite this article:
Kumar S, Gupta H, Atam V. Cerebral Stroke in Celphos Poisoning: A Rare Case Report. J Adv Res Med 2023;10(1):12-15.

DOI: https://doi.org/10.24321/2349.7181.202304

References

Gargi J, Rai H, Chanana A, Rai G, Sharma G, Bagga IJ. Current trend of poisoning - a hospital profile. J Indian

Med Assoc. 2006;104(2):72-3,94. [PubMed] [Google Scholar]

Moghadamnia AA. An update on toxicology of aluminum phosphide. Daru. 2012;20(1):25. [PubMed]

[Google Scholar]

Moazezi Z, Abedi SH. A successful management of aluminium phosphide intoxication. Caspian J Intern

Med. 2011;2(3):286-8. [PubMed] [Google Scholar]

Nath NS, Bhattacharya I, Tuck AG, Schlipalius DI, Ebert PR. Mechanisms of phosphine toxicity. J Toxicol. 2011;

:494168. [PubMed] [Google Scholar]

Brautbar N, Howard J. Phosphine toxicity: report of two cases and review of the literature. Toxicol Ind

Health. 2002;18(2):71-5. [PubMed] [Google Scholar]

Kurzbauer H, Kiesler A. [Occupational phosphine poisoning]. Neurol Neurochir Pol. 1987;21(4-5):415- 7. Polish. [PubMed] [Google Scholar]

Dave HH, Dave TH, Rakholia VG, Kharod PN, Jaju HJ. Delayed haemorrhagic stroke following accidental

aluminium phosphide ingestion. J Assoc Physicians India. 1994;42(1):78-9. [PubMed] [Google Scholar]

Almasieh M, Lieven CJ, Levin LA, Polo AD. A cellpermeable phosphine-borane complex delays retinal

ganglion cell death after axonal injury through activation of the pro-survival extracellular signal-regulated kinase 1/2 pathway. J Neurochem. 2011;118(6):1075-86. [PubMed] [Google Scholar]

Anger F, Paysant F, Brousse F, Le Normand I, Develay P, Galliard Y, Baert A, Le Gueut MA, Pepin G, Anger JP.

Fatal aluminum phosphide poisoning. J Anal Toxicol. 2000;24(2):90-2. [PubMed] [Google Scholar]

Sinha US, Kapoor AK, Singh AK, Gupta A, Mehrotra R. Histopathological changes in cases of aluminium

phosphide poisoning. Indian J Pathol Microbiol. 2005;48(2):177-80. [PubMed]

Published
2024-03-16