Association between Chronic Obstructive Pulmonary Disease and Severity of COVID-19 in a Tertiary Care Centre of Pune City, Maharashtra

Association of COPD and COVID-19 severity

  • Minal Hatnapure Junior Resident III, Department of Community Medicine, BJ Government Medical College, Pune, Maharashtra, India.
  • Malangori A Parande Associate Professor, Department of Community Medicine, BJ Government Medical College, Pune, Maharashtra, India.
  • Muralidhar P Tambe Dean and Professor and Head, Department of Community Medicine, BJ Government Medical College, Pune, Maharashtra, India.
  • Ganesh R Jagdale Junior Resident III, Department of Community Medicine, BJ Government Medical College, Pune, Maharashtra, India.
  • Priyanka Salunke Junior Resident III, Department of Community Medicine, BJ Government Medical College, Pune, Maharashtra, India.
  • Namrata Mule Senior Resident, Department of Community Medicine, BJ Government Medical College, Pune, Maharashtra, India.
  • Vidya Pawar Junior Resident II, Department of Community Medicine, BJ Government Medical College, Pune, Maharashtra, India.
Keywords: COVID-19, COPD, Mechanical Ventilation, Severity of COVID-19

Abstract

Background: COVID-19 is a global pandemic caused by SARS-CoV2, spreading across every continent in world. The risk of developing severe COVID-19 with underlying disorder like COPD might be higher as compared to patients with no comorbidity. This study was undertaken to assess the association between COPD and severity of COVID-19.

Material & Methods: This was a hospital-based cohort study conducted between July to December, 2020. Study subjects were confirmed COVID-19 patients admitted to this tertiary care centre and all patients were followed up to final outcome as discharge or death. Depending upon the history of COPD total 113 COVID-19 patients with COPD (exposed) and 339 COVID-19 patients without history of COPD (unexposed) were included in analysis. Statistical analysis was done using logistic regression analysis, and adjusted odd’s ratio with 95% CI were calculated.

Results: Age >60 years (OR = 1.38, 95% CI 1.12–3.30) and breathlessness (OR = 2.42, 95% CI 1.21–4.85) were independent risk factors for mortality in COVID-19 patients. In addition to this, other co-morbidities were associated with mechanical ventilation. On multivariable analyses, COPD was not significantly associated with mortality in COVID-19 (OR 0.93; 95% CI 0.15–1.58).

Conclusion: Underlying COPD was not an independent risk factor for poor outcome in COVID-19 patients.

How to cite this article:
Hatnapure M, Parande MA, Tambe MP, Jagdale GR, Salunke P, Mule N, Pawar V. Association between Chronic Obstructive Pulmonary Disease and Severity of COVID-19 in a Tertiary Care Centre of Pune City, Maharashtra. Special Issue - COVID-19 & Other Communicable Disease. 2022;24-29.

DOI: https://doi.org/10.24321/0019.5138.202204

References

Worldometer [Internet]. Coronavirus update (Live); [cited 2021 Oct 1]. Available from: https://www.worldometers.info/coronavirus/.

Tambe MP, Parande MA, Tapare VS, Borle PS, Lakde RN, Shelke SC, BJMC COVID Epidemiology group. An epidemiological study of laboratory confirmed COVID-19 cases admitted in a tertiary care hospital of Pune, Maharashtra. Indian J Public Health. 2020 Jun;64:S183-7. [PubMed] [Google Scholar]

WHO [Internet]. WHO coronavirus disease (COVID-19) dashboard; [cited 2021 Nov 5]. Available from: https://COVID19.who.int/.

Jagdale GR, Parande MA, Borle PS, Tapare VS, Tambe MP, Wavare S, Hatnapure M, Salunke P, Shinde P, Paunikar A. Secondary Attack Rate among the Contacts of COVID-19 Patients at the Beginning of the Pandemic in Pune City of Western Maharashtra, India. J Commun Dis. 2021;53(3):51-9. [Google Scholar]

Sanyaolu A, Okorie C, Marinkovic A, Patidar R, Younis K, Desai P, Hosein Z, Padda I, Mangat J, Altaf M. Comorbidity and its impact on Patients with COVID-19. SN Compr Clin Med. 2020 25:1-8. [PubMed] [Google Scholar]

Andrews MA, Areekal B, Rajesh KR, Krishnan J, Suryakala R, Krishnan B, Muraly CP, Santhosh PV. First confirmed case of COVID-19 infection in India: A case report. Indian J Med Res. 2020 May;151(5):490-2. [PubMed] [Google Scholar]

COVID-19 Pandemic in Maharashtra; [cited 2021 Oct 1]. Available from: https://en.wikipedia.org/wiki/COVID-19_pandemic_in_Maharashtra.

COVID-19 dashboard by Government of Maharashtra [cited 2021 Oct 1]. Available from: https://www.COVID19maharashtragov.in/mh-COVID/dashboard#?_trenddis=all.

COVID19 progression in Pune and Maharashtra [cited 2021 Oct 1]. Available from: http://www.cessi.in/coronavirus/pune. Accessed on 1st Oct 2021.

Chavhan P, Jadhav Y, Kendre V, Tambe M, Parande M, Borle PS, Jagdale G, Shivshette R. COVID-19 vaccine acceptance by health care personnel in Pune city, Maharashtra. Int J Community Med Public Health. 2021 Jul;19(1):1-5. [Google Scholar]

Best medical practice on chronic obstructive pulmonary disease; [cited 2020 Jun 20]. Available from https://bestpractice.bmj.com/topics/en-us/7.

Ministry of health and family welfare, Government of India. Guidance document on appropriate Management of suspect/confirmed cases of COVID-19 cases, version 2; [cited 20th June 2020]. Available from: https://www.mohfw.gov.in/pdf/FinalGuidanceonMangaementofCOVIDcasesversion2.pdf .

Zhao Q, Meng M, Kumar R, Wu Y, Huang J, Lian N, Deng Y, Lin S. The impact of COPD and smoking history on the severity of COVID-19: A systemic review and meta-analysis. J Med Virol. 2020 Oct;92(10):1915-21. [PubMed] [Google Scholar]

Indian Council of Medical Research, Department of Health Research, Ministry of Health and Family Welfare, Government of India. Advisory on newer additional strategies for COVID-19 testing; [cited 2020 Jun 5]. Available from: https://www.icmr.gov.in/pdf/COVID/strategy/New_additional_Advisory_23062020_3.pdf.

Guan WJ, Liang WH, Zhao Y, Liang HR, Chen ZS, Li YM, Liu XQ, Chen RC, Tang CL, Wang T, Ou CQ, Li L, Chen PY, Sang L, Wang W, Li JF, Li CC, Ou LM, Cheng B, Xiong S, Ni ZY, Xiang J, Hu Y, Liu L, Shan H, Lei CL, Peng YX, Wei L, Liu Y, Hu YH, Peng P, Wang JM, Liu JY, Chen Z, Li G, Zheng ZJ, Qiu SQ, Luo J, Ye CJ, Zhu SY, Cheng LL, Ye F, Li SY, Zheng JP, Zhang NF, Zhong NS, He JX; China Medical Treatment Expert Group for COVID-19. Comorbidity and its impact on 1590 patients with COVID-19 in China: a nationwide analysis. Eur Respir J. 2020 May;55(5):2000547. [PubMed] [Google Scholar]

Feng Y, Ling Y, Bai T, Xie Y, Huang J, Li J, Xiong W, Yang D, Chen R, Lu F, Lu Y, Liu X, Chen Y, Li X, Li Y, Summah HD, Lin H, Yan J, Zhou M, Lu H, Qu J. COVID-19 with different severities: a multicenter study of clinical features. Am J Respir Crit Care Med. 2020 Jun;201(11):1380-8. [PubMed] [Google Scholar]

Cai Q, Chen F, Wang T, Luo F, Liu X, Wu Q, He Q, Wang Z, Liu Y, Liu L, Chen J, Xu L. Obesity and COVID-19 severity in a designated hospital in Shenzhen, China. Diabetes Care. 2020 Jul;43(7):1392-8. [PubMed] [Google Scholar]

Alqahtani JS, Oyelade T, Aldhahir AM, Alghamdi SM, Almehmadi M, Alqahtani AS, Quaderi S, Mandal S, Hurst JR. Prevalence, severity and mortality associated with COPD and smoking in patients with COVID-19: A rapid systematic review and meta- analysis. PLoS One. 2020 May;15(5):e0233147. [PubMed] [Google Scholar]

Lee SC, Son KJ, Han CH, Park SC, Jung JY. Impact of COPD on COVID-19 prognosis: A nationwide population-based study in South Korea. Sci Rep. 2021 Feb;11(1):3735. [PubMed] [Google Scholar]

Jung Y, Wee JH, Kim JH, Choi HG. The effects of previous asthma and COPD on the susceptibility to and severity of COVID-19: A nationwide cohort study in South Korea. J Clin Med. 2021 Oct;10(20):4626. [PubMed] [Google Scholar]

Published
2022-03-15

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