Vaccine Hesitancy: An Old Phenomenon Still Alive in the COVID Vaccine Era

  • Jasmine M Assistant Professor, Department of Community Medicine, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India.
  • Suganthi S Associate Professor, Department of Community Medicine, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India.
  • Vinoth Gnana Chellaiyan Associate Professor, Department of Community Medicine, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam, Tamil Nadu, India.
Keywords: Vaccination, Hesitancy, Acceptance, Parents, Immunisation

Abstract

With the introduction of vaccines, mortality and morbidity among children have significantly reduced. While a good proportion of the population accepts the vaccine, still a gap remains in the immunisation coverage in India. A growing number of people are delaying or refusing the vaccines. This phenomenon is called “vaccine hesitancy.†In spite of the tremendous effort to develop an effective COVID 19 vaccine, a major deterrent for coverage of the same is vaccine hesitancy towards the approved and future COVID-19 vaccination. Consideration and addressing the determinants for such hesitancy is the need of the hour to surge the vaccine coverage. The databases were searched for English- language articles. The data were extracted from PubMed, Web of Science, Google Scholar databases and websites including WHO, UNICEF etc. Keywords such as vaccine hesitancy, vaccine acceptance, parents, confidence, counselling etc were used. This review was done to explore the history and factors responsible for vaccine hesitancy.

How to cite this article:
Jasmine M, Suganthi S, Chellaiyan VG. Vaccine Hesitancy: An Old Phenomenon Still Alive in the COVID Vaccine Era. Special Issue - COVID-19 & Other Communicable Disease. 2022;215-221.

DOI: https://doi.org/10.24321/0019.5138.202234

References

MacDonald NE. Vaccine hesitancy: definition, scope and determinants. Vaccine. 2015 Aug;33(34):4161-4. [PubMed] [Google Scholar]

Hotez P. America and Europe’s new normal: the return of vaccine-preventable diseases. Pediatr Res. 2019

Jun;85(7):912-4. [PubMed] [Google Scholar]

World Health Organization [Internet]. Measles; 2019 [cited 2021 Mar 29]. Available from: https://www.who.

int/news-room/fact-sheets/detail/measles

UNICEF [Internet]. Immunization; [cited 2021 Mar 29]. Available from: https://www.unicef.org/india/what-wedo/ immunization

Gurnani V, Haldar P, Aggarwal MK, Das MK, Chauhan A, Murray J, Arora NK, Jhalani M, Sudan P. Improving

vaccination coverage in India: lessons from Intensified Mission Indradhanush, a cross-sectoral systems strengthening strategy. BMJ. 2018 Dec;363:k4782. [PubMed] [Google Scholar]

National Family Health Survey [Internet]. NFHS-4 fact sheets for key indicators based on final data; 2017 [cited

Mar 29]. Available from: http://rchiips.org/NFHS/factsheet_NFHS-4.shtml

Durbach N. Bodily matters: the anti-vaccination movement in England, 1853–1907. Duke University Press; 2005. [Google Scholar]

Durbach N. ‘They might as well brand us’: workingclass resistance to compulsory vaccination in Victorian

England. Soc Hist Med. 2000 Apr;13(1):45-63. [PubMed] [Google Scholar]

Swales JD. The Leicester anti-vaccination movement. Lancet. 1992 Oct;340(8826):1019-21. [PubMed] [Google

Scholar]

Poland GA, Jacobson RM. The age-old struggle against the antivaccinationists. N Engl J Med. 2011 Jan;364(2):97-9. [PubMed] [Google Scholar]

World Health Organization [Internet]. National programmes and systems; [cited 2021 Mar 29]. Available from: https://www.who.int/immunization/programmes_systems/en/

National Health Portal of India [Internet]. Universal Immunisation Programme; [cited 2021 Mar 29. Available

from: https://www.nhp.gov.in/universal-immunisationprogramme_pg

Kulenkampff M, Schwartzman JS, Wilson J. Neurological complications of pertussis inoculation. Arch Dis Child.

Jan;49(1):46-9. [PubMed] [Google Scholar]

Miller D, Wadsworth J, Ross E. Severe neurological illness: further analyses of the British National Childhood

Encephalopathy Study. Tokai J Exp Clin Med. 1988;13 Suppl:145-55. [PubMed] [Google Scholar]

Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M, Berelowitz M, Dhillon AP, Thomson MA,

Harvey P, Valentine A, Davies SE, Walker-Smith JA. Ileallymphoid-nodular hyperplasia, non-specific colitis, and

pervasive developmental disorder in children. Lancet. 1998 Feb;351:637-41. [PubMed] [Google Scholar]

Dyer C. Lancet retracts Wakefield’s MMR paper. BMJ. 2010 Feb;340:c696. [PubMed] [Google Scholar]

Bernard S, Enayati A, Redwood L, Roger H, Binstock T. Autism: a novel form of mercury poisoning. Med

Hypotheses. 2001 Apr;56(4):462-71. [PubMed] [GoogleScholar]

Immunization Safety Review Committee. Immunization safety review. Washington, DC: Vaccines and Autism

Board of Health Promotion and Disease Prevention, Institute of Medicine. National Academy Press; 2004.

Gatto M, Agmon-Levin N, Soriano A, Manna R, Maoz-Segal R, Kivity S, Doria A, Shoenfeld Y. Human papillomavirus vaccine and systemic lupus erythematosus. Clin Rheumatol. 2013 Sep;32(9):1301-7. [PubMed] [Google Scholar]

Grimaldi-Bensouda L, Rossignol M, Koné-Paut I, Krivitzky A, Lebrun-Frenay C, Clet J, Brassat D, Papeix C, Nicolino M, Benhamou PY, Fain O, Costedoat-Chalumeau N, Courcoux MF, Viallard JF, Godeau B, Papo T, Vermersch P, Bourgault-Villada I, Breart G, Abenhaim L; PGRx-

AD Study Group. Risk of autoimmune diseases and human papillomavirus (HPV) vaccines: six years of asereferent surveillance. J Autoimmun. 2017 May;79:84-90. [PubMed] [Google Scholar]

Dubé E, Laberge C, Guay M, Bramadat P, Roy R, Bettinger JA. Vaccine hesitancy: an overview. Hum Vaccin Immunother. 2013 Aug;9(8):1763-73. [PubMed] [Google Scholar]

Kouzy R, Abi Jaoude J, Kraitem A, El Alam MB, Karam B, Adib E, Zarka J, Traboulsi C, Akl EW, Baddour K. Coronavirus goes viral: quantifying the COVID-19 misinformation epidemic on Twitter. Cureus. 2020

Mar;12(3):e7255. [PubMed] [Google Scholar]

Keelan J, Pavri-Garcia V, Tomlinson G, Wilson K. YouTube as a source of information on immunization: a content analysis. JAMA. 2007 Dec;298:2481-4. [PubMed] [Google Scholar]

Broniatowski DA, Jamison AM, Qi S, AlKulaib L, Chen T, Benton A, Quinn SC, Dredze M. Weaponized health

communication: Twitter bots and Russian trolls amplify the vaccine debate. Am J Public Health. 2018;108:1378-

[PubMed] [Google Scholar]

Reliefweb [Internet]. Disinformation and disease: social media and the Ebola epidemic in the Democratic

Republic of the Congo; 2019 [cited 2021 Mar 29]. Available from: https://reliefweb.int/report/democraticrepublic-

congo/disinformation-and-disease-socialmedia-and-ebola-epidemic

Wielders CC, Van Binnendijk RS, Snijders BE, Tipples GA, Cremer J, Fanoy E, Dolman S, Ruijs WL, Boot HJ, De Melker HE, Hahné SJ. Mumps epidemic in orthodox religious low-vaccination communities in the Netherlands and Canada, 2007 to 2009. Euro Surveill. 2011 Oct;16(41):19989. [PubMed] [Google Scholar]

PelÄić G, KaraÄić S, Mikirtichan GL, Kubar OI, Leavitt FJ, Tai MC, Morishita N, Vuletić S, TomaÅ¡ević L. Religious

exception for vaccination or religious excuses for avoiding vaccination. Croatian Med J. 2016 Oct;57(5):516.[PubMed] [Google Scholar]

Kestenbaum LA, Feemster KA. Identifying and addressing vaccine hesitancy. Pediatric Ann. 2015 Apr;44(4):e71-5. [PubMed] [Google Scholar]

Berry NJ, Henry A, Danchin M, Trevena LJ, Willaby HW, Leask J. When parents won’t vaccinate their children:

a qualitative investigation of Australian primary care providers’ experiences. BMC Pediatr. 2017 Dec;17(1):19.

[PubMed] [Google Scholar]

Paterson P, Meurice F, Stanberry LR, Glismann S, Rosenthal SL, Larson HJ. Vaccine hesitancy and healthcare providers. Vaccine. 2016 Dec;34(52):6700-6. [PubMed] [Google Scholar]

Schoeps A, Ouedraogo N, Kagone M, Sie A, Müller O, Becher H. Socio-demographic determinants of timely

adherence to BCG, Penta3, measles, and complete vaccination schedule in Burkina Faso. Vaccine. 2013 Dec;32(1):96-102. [PubMed] [Google Scholar]

Rahman M, Obaida-Nasrin S. Factors affecting acceptance of complete immunization coverage of children under five years in rural Bangladesh. Salud Publica Méx. 2010 Mar-Apr;52:134-40. [PubMed] [Google Scholar]

Okoro JC, Ojinnaka NC, Ikefuna AN, Onyenwe NE. Sociodemographic influences on immunization of

children with chronic neurological disorders in Enugu, Nigeria. Trials Vaccinol. 2015 Jan;4:9-13. [Google Scholar]

World Health Organization [Internet]. Vaccines and immunization; [cited 2021 Mar 29]. Available from:

https://www.who.int/westernpacific/health-topics/vaccines-and-immunization

Evans M, Stoddart H, Condon L, Freeman E, Grizzell M, Mullen R. Parents’ perspectives on the MMR immunisation: a focus group study. Br J Gen Pract. 2001 Nov;51(472):904-10. [PubMed] [Google Scholar]

Cassell JA, Leach M, Poltorak MS, Mercer CH, Iversen A, Fairhead JR. Is the cultural context of MMR rejection

a key to an effective public health discourse? Public Health. 2006 Sep;120(9):783-94. [PubMed] [Google

Scholar]

Taddio A, Ipp M, Thivakaran S, Jamal A, Parikh C, Smart S, Sovran J, Stephens D, Katz J. Survey of the prevalence of immunization non-compliance due to needle fears in children and adults. Vaccine. 2012 Jul;30(32):4807-12. [PubMed] [Google Scholar]

Smith PJ, Humiston SG, Marcuse EK, Zhao Z, Dorell CG, Howes C, Hibbs B. Parental delay or refusal of vaccine doses, childhood vaccination coverage at 24 months of age, and the Health Belief Model. Public

Health Rep. 2011 Jul;126(2_suppl):135-46. [PubMed] [Google Scholar]

Benin AL, Wisler-Scher DJ, Colson E, Shapiro ED, Holmboe ES. Qualitative analysis of mothers’ decisionmaking

about vaccines for infants: the importance of trust. Pediatrics. 2006 May;117:1532-41. [PubMed] [Google Scholar]

Worldometer [Internet]. COVID Live Update: 245,832,699 cases and 4,988,606 deaths from the

Coronavirus; 2021 [cited 2021 Oct 28]. Available from: https://www.worldometers.info/coronavirus/

Viner RM, Russell SJ, Croker H, Packer J, Ward J, Stansfield C, Mytton O, Bonell C, Booy R. School closure and

management practices during coronavirus outbreaks including COVID-19: a rapid systematic review. Lancet

Child Adolesc Health. 2020 May;4(5):397-404. [PubMed] [Google Scholar]

Arede M, Bravo-Araya M, Bouchard É, Singh Gill G, Plajer V, Shehraj A, Adam Shuaib Y. Combating vaccine

hesitancy: teaching the next generation to navigate through the post truth era. Front Public Health. 2019

Jan;6:381. [PubMed] [Google Scholar]

Dubé E, Vivion M, MacDonald NE. Vaccine hesitancy, vaccine refusal and the anti-vaccine movement: influence, impact and implications. Expert Rev Vaccines. 2015 Jan;14(1):99-117. [PubMed] [Google Scholar]

Brunson EK, Schoch-Spana M; Working Group on Readying Populations for COVID-19 Vaccine. A socialand behavioral research agenda to facilitate COVID-19 vaccine uptake in the United States. Health Secur. 2020

Aug;18(4):338-44. [PubMed] [Google Scholar]

Kirkcaldy RD, King BA, Brooks JT. COVID-19 and postinfection immunity: limited evidence, many remaining questions. JAMA. 2020 Jun;323(22):2245-6. [PubMed] [Google Scholar]

Kreps S, Prasad S, Brownstein JS, Hswen Y, Garibaldi BT, Zhang B, Kriner DL. Factors associated with US

adults’ likelihood of accepting COVID-19 vaccination. JAMA Netw Open. 2020 Oct;3(10):e2025594.[PubMed][Google Scholar]

Corey L, Mascola JR, Fauci AS, Collins FS. A strategic approach to COVID-19 vaccine R&D. Science. 2020

May;368(6494):948-50. [PubMed] [Google Scholar]

World Health Organization [Internet]. An ad hoc WHO technical consultation managing the COVID-19 infodemic: call for action, 7-8 April 2020; [cited 2021 Oct 28]. Available from: https://apps.who.int/iris/

handle/10665/334287?show=full

Kwok KO, Lai F, Wei WI, Wong SY, Tang JW. Herd immunity–estimating the level required to halt the COVID-19 epidemics in affected countries. J Inf. 2020 Jun;80(6):e32-3. [PubMed] [Google Scholar]

Loomba S, de Figueiredo A, Piatek SJ, de Graaf K, Larson HJ. Measuring the impact of COVID-19 vaccine misinformation on vaccination intent in the UK and USA. Nat Hum Behav. 2021 Mar;5(3):337-48. [PubMed]

[Google Scholar]

Pogue K, Jensen JL, Stancil CK, Ferguson DG, Hughes SJ, Mello EJ, Burgess R, Berges BK, Quaye A, Poole BD.

Influences on attitudes regarding potential COVID-19 vaccination in the United States. Vaccines. 2020 Dec;8(4):582. [PubMed] [Google Scholar]

Khamsi R. If a coronavirus vaccine arrives, can the world make enough. Nature. 2020 Apr;580(7805):578-80.

[PubMed] [Google Scholar]

Betsch C, Schmid P, Heinemeier D, Korn L, Holtmann C, Böhm R. Beyond confidence: development of a measure assessing the 5C psychological antecedents of vaccination. PloS One. 2018 Dec;13(12):e0208601.

[PubMed] [Google Scholar]

Larson HJ, Clarke RM, Jarrett C, Eckersberger E, Levine Z, Schulz WS, Paterson P. Measuring trust in vaccination: a systematic review. Hum Vaccin Immunother. 2018 Jul;14(7):1599-609. [PubMed] [Google Scholar]

Sadaf A, Richards JL, Glanz J, Salmon DA, Omer SB. A systematic review of interventions for reducing parental

vaccine refusal and vaccine hesitancy. Vaccine. 2013 Sep;31:4293-304. [PubMed] [Google Scholar]

Published
2022-03-16