Viral Malaria-Induced Pancytopenia in a G6PD Deficient Patient: A Rare Clinical Intersection

  • Harshil Gadhiya Research Scholar, School of Pharmacy, R K University, Rajkot, Gujarat, India
  • Riddhi Shingala Student, School of Pharmacy, R K University, Rajkot, Gujarat, India
  • Dhirangi Gajipara Student, School of Pharmacy, R K University, Rajkot, Gujarat, India
  • Saurabh Sanja Student, School of Pharmacy, R K University, Rajkot, Gujarat, India
  • Yash Radhanpura Student, School of Pharmacy, R K University, Rajkot, Gujarat, India
  • Kajal Kalaeia Assistant Professor, School of Pharmacy, R K University, Rajkot, Gujarat, India
  • Kushal Parekh Assistant Professor, School of Pharmacy, R K University, Rajkot, Gujarat, India
  • Ravi Ajudia Associate Professor, School of Pharmacy, R K University, Rajkot, Gujarat, India
Keywords: Malaria, G6PD, Pancytopenia, Hemolysis, Antimalarial Therapy, Haematological Complications

Abstract

In a rare instance, a 22-year-old woman with malaria who also had genetic glucose-6-phosphate dehydrogenase (G6PD) impairment developed pancytopenia. Pancytopenia is rare and led to more research, although anemia is a typical hematological result in malaria. Because of the danger of hemolysis, G6PD deficiency limited the use of common antimalarial medications, complicating the therapeutic course. Close hematologic monitoring and,-supportive treatment, including blood transfusions and G6PD-safe antimalarial medication, were used to
treat the patient. Other potential causes of bone marrow suppression, including viral co-infections, were excluded. This situation highlights the need for personalized treatment plans in complex medical cases and
the importance of considering enzyme disorders like G6PD deficiency in patients with unusual malaria symptoms.

How to cite this article:
Gadhiya H, Shingala R, Gajipara D, Sanja S, Radhanpura Y, Kalaeia K, Parekh K, Ajudia R. Viral Malaria-Induced Pancytopenia in a G6PD Deficient Patient: A Rare Clinical Intersection. J Commun Dis. 2025;57(2):242-245.

DOI: https://doi.org/10.24321/0019.5138.202560

References

Gething PW, Van Boeckel TP, Smith DL, Guerra CA, Patil AP, Snow RW, Hay SI. Modelling the global constraints

of temperature on transmission of Plasmodium falciparum and P. vivax. Parasites & vectors. 2011 Dec;4:1-1. [Google Scholar] [Pubmed]

Escalante AA, Cepeda AS, Pacheco MA. Why Plasmodium vivax and Plasmodium falciparum are so different?

A tale of two clades and their species diversities. Malaria Journal. 2022 May 3;21(1):139. [Google Scholar] [Pubmed]

Published
2025-06-30