Dengue Fever: A Rare Perspective and Emerging Strategies for Sustainable Global Control

Priyanka  Malaiyappan; Esther Deva  Ramya; Vettrivel  Arul; Gokulraj  Ganesan

Priyanka Malaiyappan Medical Officer, Manam Healthcare Hospital, Tirupur, Tamil Nadu, India
Esther Deva Ramya Professor & Head, Department of Homoeopathic Repertory and Case Taking, Vinayaka Mission’s Homoeopathic Medical College & Hospital, Vinayaka Mission’s Research Foundation (DU), Tamil Nadu, India
Vettrivel Arul Assistant Professor, Department of Community Medicine, Research Methodology & Biostatistics, Vinayaka Mission’s Homoeopathic Medical College & Hospital, Vinayaka Mission’s Research Foundation (DU), Tamil Nadu, India
Gokulraj Ganesan Assistant Professor, Department of Surgery, Excel Homoeopathy Medical College, Dr M.G.R Medical University, Tamil Nadu, Chennai, India

Keywords: Dengue fever, Vector-borne disease, Global health, Emerging therapeutics

Abstract

Dengue fever remains one of the most pressing global public health challenges, driven by its increasing incidence, expanding geographical reach, and complex clinical manifestations. This review synthesises
current knowledge on dengue’s epidemiology, transmission dynamics, and clinical spectrum, highlighting the roles of Aedes mosquitoes, environmental factors, and socioeconomic determinants in shaping disease patterns. We explore the immune-mediated mechanisms underlying severe dengue as well as emerging insights into epigenetic modifications that affect both acute and long-term outcomes. The multifaceted impact of dengue is further underscored by its occupational, maternal, and neonatal health complications, which contribute substantially to the economic and healthcare burdens in endemic regions. Innovative therapeutic strategies, including the development of monoclonal antibodies and novel vaccines, alongside integrated
vector control and early warning systems, are advancing the fight against dengue. Future research directions and policy recommendations emphasises the need for affordable diagnostics, refined prognostic biomarkers, improved surveillance, and climate-adapted public health interventions to mitigate dengue’s spread and severity. Urban planning, though underexplored, has transformative potential in mitigating dengue through mosquito-resistant infrastructure and climateadaptive strategies. Future efforts must integrate interdisciplinary
solutions focusing on innovative therapeutics, targeted prevention, and strengthened healthcare systems to combat dengue effectively and address its evolving challenges in both endemic and emerging regions.

How to cite this article:
Malaiyappan P, Ramya E D, Arul V, Ganesan G.
Dengue Fever: A Rare Perspective and Emerging
Strategies for Sustainable Global Control. J
Commun Dis. 2025;57(2):45-56.

DOI: https://doi.org/10.24321/0019.5138.202536

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