Role of Latent Genital Tuberculosis in the Relation  between Levels of Vitamin D and Anti-müllerian  Hormone among Female Patients with Infertility

Abira Datta; Arabinda Das; Siddhartha Chatterjee

Abira Datta Senior Scientific Officer, Central Research Lab, PGIMSR & ESI Hospital, Manicktala, Kolkata, India
Arabinda Das Department of Statistics, Acharya Prafulla Chandra College, Kolkata, India
Siddhartha Chatterjee Director, Calcutta Fertility Mission, Bondel Road, Kolkata, India

Keywords: Anti-müllerian Hormone (AMH), Polymerase Chain Reaction, 25-Hydroxyvitamin D, Genital Tuberculosis, GLM Estimation

Abstract

Introduction: An association between low secretion level of anti-müllerian hormone (AMH) and low level of vitamin D in the study of female infertility has been established for a long time. This article sought to
find out the quantification of the association of the level of anti-müllerian hormone with level of vitamin D and the role of latent genital tuberculosis (LGT), considered a leading cause of female infertility, in
the association.
Materials and Methods: A total of 150 patients were recruited in this cross-sectional study who attended at reproductive medicine unit of Calcutta Fertility Mission, Kolkata. Patients were divided into two groups following the outcome of long time polymerase chain reaction (PCR) test to detect LGT. Levels of anti-müllerian hormone and vitamin D were measured for each patient.
Result: Medians of vitamin D and anti-müllerian hormone levels were significantly higher for patients from the PCR negative group (absence of LGT). The level of anti-müllerian hormone was significantly associated with the level of vitamin D (p-value < 0.01). More specifically, significant association was observed for lower levels of vitamin D and anti-müllerian hormone in the presence of LGT whereas elevated levels of anti-müllerian hormone and vitamin D were scattered most with the absence of LGT. Level of anti-müllerian hormone increased with vitamin D. Also, level of anti-müllerian hormone increased almost 3
ng/ml in the absence of LGT.
Conclusion: Association between anti-müllerian hormone and vitamin D levels was strongly affected by the presence of LGT. Low anti-müllerian hormone levels were strongly associated with vitamin D deficiency in
the presence of LGT while in the absence of LGT, elevated levels of vitamin D and anti-müllerian hormone were more dispersed with an insignificant association. Vitamin D deficiency and low anti-müllerian hormone secretion could be an indicator of latent tuberculosis and female infertility.

How to cite this article:
Datta A, Das A, Chatterjee S. Role of Latent Genital Tuberculosis in the Relation between Levels of Vitamin D and Anti-müllerian Hormone among Female Patients with Infertility. J Commun Dis. 2025;57(2):1-5.

DOI: https://doi.org/10.24321/0019.5138.202530

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