The Effect of Streptomyces-Derived Bioactive  Compounds on IL-6 Levels Exploring Antimicrobial  and Anti-inflammatory Properties in Bacterial  Infections

Bassam Qasim Mohammed; Mohsen Hashim Risan; Yasir W Issa

Bassam Qasim Mohammed Lecturer, Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq
Mohsen Hashim Risan Professor, Department of Molecular and Medical Biotechnology, College of Biotechnology, Al-Nahrain University, Baghdad, Iraq
Yasir W Issa Lecturer, Department of Anesthesia Techniques, College of Health and Medical Techniques, Middle Technical University, Baghdad, Iraq

Keywords: Streptomyces Actinomycetes, IL-6, ELISA, 16S rRNA

Abstract

Background: Streptomyces, a genus of Actinomycetes, are known for their ability to produce bioactive compounds, including antibiotics, with significant applications in medicine and agriculture.
Objective: This study’s aim is to investigate the effects of extracellular extracts from Streptomyces spp. on the inflammatory response, specifically interleukin-6 (IL-6), in various bacterial infection models.
Methods: Through 16S rRNA gene sequencing, the T2 strain was identified and shown to share a high similarity with S. actinomycinicus. Phylogenetic analysis confirmed its close evolutionary relationship with other species in the Streptomyces genus.
Results: The study found that IL-6 levels were significantly elevated in infections caused by both sensitive and resistant bacterial strains, with resistant strains showing the highest inflammatory response. Post-infection treatment with Streptomyces extracts effectively reduced IL-6 levels in sensitive bacterial infections, demonstrating the extract’s potential antimicrobial properties. However, the treatment had limited effectiveness in resistant infections, as indicated by persistent high IL-6 levels. The extract alone did not significantly alter IL-6 levels, suggesting anti-inflammatory properties without triggering an immune response.
Conclusion: Streptomyces extracts may reduce bacterial load and inflammation in infections, but limited effectiveness on resistant strains necessitates further research for more potent antibiotic-resistant treatments.

How to cite this article:
Mohammed B Q, Risan M H, Issa Y W. The Effect
of Streptomyces-Derived Bioactive Compounds
on IL-6 Levels Exploring Antimicrobial and Anti
inflammatory Properties in Bacterial Infections.
J Commun Dis. 2025;57(2):136-141.

DOI: https://doi.org/10.24321/0019.5138.202549

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